Delayed hypersensitivity response in guinea‐pig oral mucosa

Adams, D.; Williamson, John J.; Dolby, A. E.

doi:10.1002/path.1710970308

Cited by 11 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The absence of necrotic lesions in the gingiva of CFA injected primates suggested that oral mucosa reacts differently from skin and other mucous membranes. Necrosis did not occur in the granulomas produced in the gingiva of guinea pigs by Adams et al (1969), giving support to the contention that mucous membranes may differ from skin in their reaction to CFA. It is also reasonable to suggest that the early sacrifice of the primates may have preceded development of necrotic lesions.…”

supporting

confidence: 64%

Adjuvant induced destructive periodontitis in nonhuman primates A comparative study

Levy

Robertson

Dreizen

et al. 1976

J of Periodontal Research

View full text Add to dashboard Cite

Complete (CFA) and incomplete (IFA) Freund's adjuvant was injected into the periodontium of sensitized marmoset, capuchin and rhesus monkeys. All animals developed a proliferative granulomatous reaction at the injection sites. There were, however, species specific differences in the degree of destruction associated with the CFA injection. The marmosets and capuchins developed a destructive periodontitis. In the rhesus monkey, the lesion was both bone destructive and bone inductive. Tubercles containing typical Langhan's type giant cells, but without central necrosis, were only produced by the rhesus monkey. Granulation tissue with no necrosis was produced by the marmoset and capuchin monkeys. While there was some degree of periodontal destruction in all CFA injected animals, it was most severe in the marmoset followed in descending order by the capuchin and by the rhesus. The injection of IFA into the periodontium of the same animals resulted in the formation of nondestructive highly proliferative granulation tissue.

show abstract

supporting

confidence: 64%