Delayed Inflammatory Reactions After Hyaluronic Acid Filling of Neck Lines: A Case Report

Abstract

The incidence of adverse events after hyaluronic acid filling is gradually increasing. In addition to acute reactions in the early postoperative period, there have been some cases of delayed inflammatory reactions. However, such events are rarely reported in Asia, which may be due to atypical symptoms, long intervals, and misidentification of the product quality. Herein, we present a case in which erythema of the neck appeared three weeks after hyaluronic acid injection into the neck lines and a delayed inflammatory reaction was diagnosed. Watchful waiting was performed, and the erythema subsided spontaneously after two weeks. This case suggests that in patients with a history of hyaluronic acid injections who develop allergic and inflammatory reactions after an interval, it is important to consider whether the reaction is a delayed inflammatory reaction, and if aggressive intervention is necessary.

Adverse events associated with the vaccine and SARS-CoV 2 virus in patients with facial aesthetic procedures

“…The COVID-19 pandemic then led to research on the relationship between facial aesthetic procedures (botulinum toxin type A and hyaluronic acid fillers) as well as the development of inflammatory reactions in patients infected with SARS-CoV-2 or after vaccination (Naouri et al, 2023). There are already studies that report that SARS-CoV-2 binds to and blocks angiotensinconverting enzyme 2 (ACE2) via the S (spike) protein to access the cell, which may be a potential mechanism for the development of adverse events in those vaccinated or infected with COVID-19 in patients who have received HA filler injections or botulinum toxin type A, for the purpose of facial aesthetic procedures (Li et al, 2023).…”