Delayed regional metastasis from midfacial squamous carcinomas

Netterville, James L.; Sinard, Robert J.; Bryant, Grady Lee; Burkey, Brian B.

doi:10.1002/(sici)1097-0347(199807)20:4<328::aid-hed8>3.3.co;2-5

Cited by 17 publications

(20 citation statements)

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“…The assumed lymph node status evaluated clinically by sonography, CT, or MRI before definitive radiotherapy is usually higher than the histopathologically verified neck status . Together with the inclusion of studies that did not exclude cancers of the nasal vestibule and paranasal sinuses this might be the reason for the higher rate of regional disease in some recent studies, as also suggested by Scurry et al However, Netterville et al reported a series of 12 patients with regional metastases of midface SCCs and stated that these metastases often arise in a delayed fashion. Therefore, a careful follow‐up, especially of the neck levels I and II, is essential.…”

Section: Discussionmentioning

confidence: 99%

Squamous cell cancer of the nasal cavity: New insights and implications for diagnosis and treatment

2016

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Local tumor control is crucial, even if it makes radical surgery necessary. Postoperative epithetic treatment enables reliable follow-up examinations. Regional metastases at the time of diagnosis are rare. Neck dissection should therefore be reserved for cases of suspected metastasis. HPV may also play a role in the etiology of SCC of the nasal cavity. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2112-E2117, 2016.

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Section: Discussionmentioning

confidence: 99%

Squamous cell cancer of the nasal cavity: New insights and implications for diagnosis and treatment

2016

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“…It is imperative to monitor patients treated for cutaneous SCC for recurrence as well as patients with increased susceptibility for developing cutaneous SCC (eg, because of immunosuppression or xeroderma pigmentosum). Multiple sources in the literature indicate that the recurrence of cutaneous SCC and/or regional metastasis most frequently occur within 2 years of treatment, although intervals up to 5 years and very rarely beyond have been reported . This information constitutes the basis for patient follow‐up, although no universal standardized follow‐up schedule exists.…”

Section: Elective Nodal Dissection Of the Head And Neckmentioning

confidence: 99%

Review of high‐risk features of cutaneous squamous cell carcinoma and discrepancies between the American Joint Committee on Cancer and NCCN Clinical Practice Guidelines In Oncology

et al. 2016

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Cutaneous squamous cell carcinoma (SCC) is a malignancy that arises from epidermal keratinocytes. Although the majority of cutaneous SCC cases are easily treated without further complication, some behave more aggressively and carry a poor prognosis. These "high-risk" cutaneous SCCs commonly originate in the head and neck and have an increased tendency toward recurrence, local invasion, and distant metastasis. Factors for high-risk cutaneous SCC include large size (>2 cm), a deeply invasive lesion (>2 mm), incomplete excision, high-grade/desmoplastic lesions, perineural invasion (PNI), lymphovascular invasion, immunosuppression, and high-risk anatomic locations. Both the National Comprehensive Cancer Network (NCCN ) and the American Joint Committee on Cancer (AJCC) identify several of these high-risk features of cutaneous SCC. The purpose of this article was to review the high-risk features included in these guidelines, as well as their notable discrepancies and omissions. We also provide a brief overview of current prophylactic measures, surgical options, and adjuvant therapies for high-risk cutaneous SCC. © 2016 Wiley Periodicals, Inc. Head Neck 39: 578-594, 2017.

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“…Median time for the development of nodal metastases following treatment of an index SCC is approximately 12 months, although late relapse (2-3 years) is well documented and justifies ongoing regular follow-up of patients following treatment of a highrisk SCC. 45,46 The pattern of distribution of nodal metastases is approximately equally divided between the parotid alone, the parotid and neck, and the neck alone (levels I-V).…”

Section: Metastatic Nodal Squamous Cell Carcinomamentioning

confidence: 99%

Cutaneous head and neck squamous cell carcinoma metastatic to parotid and cervical lymph nodes

2007

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Nonmelanoma skin cancers occur at an epidemic rate in Australia and are increasing in incidence worldwide. In most patients, local treatment is curative. However, a subset of patients will be diagnosed with a high-risk cutaneous squamous cell carcinoma (SCC) and are defined as patients at increased risk of developing metastases to regional lymph nodes. Patients with high-risk SCC may be identified based on primary lesion and patient factors. Most cutaneous SCC arises on the sun-exposed head and neck. The parotid and upper cervical nodes are common sites for the development of metastases arising from ear, anterior scalp, temple/forehead, or scalp SCC. The mortality and morbidity associated with high-risk cutaneous SCC is usually a consequence of uncontrolled metastatic nodal disease and, to a lesser extent, distant metastases. Patients with operable nodal disease have traditionally been recommended for surgery. The efficacy of adjuvant radiotherapy has previously been questioned based on weak evidence in the early literature. Recent evidence from larger studies has, however, strengthened the case for adjuvant radiotherapy as a means to improve locoregional control and survival. Despite this, many patients still experience relapse and die. Research aimed at improving outcome such as a randomized trial incorporating the addition of chemotherapy to adjuvant radiotherapy is currently in progress in Australia and New Zealand. Ongoing research also includes the development of a proposed new staging system and investigating the role of molecular factors such as the epidermal growth factor receptor.

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Delayed regional metastasis from midfacial squamous carcinomas

Cited by 17 publications

References 0 publications

Squamous cell cancer of the nasal cavity: New insights and implications for diagnosis and treatment

Squamous cell cancer of the nasal cavity: New insights and implications for diagnosis and treatment

Review of high‐risk features of cutaneous squamous cell carcinoma and discrepancies between the American Joint Committee on Cancer and NCCN Clinical Practice Guidelines In Oncology

Cutaneous head and neck squamous cell carcinoma metastatic to parotid and cervical lymph nodes

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