Delayed Treatment of Papillary Thyroid Carcinoma Arising from Struma Ovarii in a Patient with History of Bilateral Salpingo-Oophorectomy: A Case Report

Collins, Anton; Bodenner, Donald; Chen, Chien; Stone, Pamela J.B.; Stack, Brendan C.

doi:10.4158/ep11253.cr

Cited by 11 publications

(4 citation statements)

References 15 publications

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“…A diagnostic and therapeutic characterization of struma ovarii is needed as it may harbor a differentiated thyroid cancer ( 1 ). Even the generic term “malignant struma ovarii” has been, in fact, replaced with the more appropriate “thyroid carcinoma arising in struma ovarii” (TCASO), namely when histological features support the existence of a well-differentiated thyroid carcinoma ( 3 , 14 , 15 ). Molecular evidence that malignant struma ovarii and differentiated thyroid cancer may share similar pathogenic events ( 3 , 16 ) has been presented.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, a delayed appearance of distant metastasis has been described three years after the treatment in patients with struma ovarii who underwent pelvic surgery alone ( 18 ). A not negligible fraction (6%) of patients with longer follow up, developed distant metastases after one, three and seven years ( 15 ). Two-thirds of metastasis occurred at the time of disease recurrence, rather than at first presentation ( 7 ); in fact, a number of cases were diagnosed as malignant only following the detection of metastatic recurrences ( 7 ).…”

Section: Discussionmentioning

confidence: 99%

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A Case Report of Thyroid Carcinoma Confined To Ovary And Concurrently Occult in The Thyroid: Is Conservative Treatment Always Advised?

Brusca¹,

Duca²,

Salvatori

et al. 2014

Int J Endocrinol Metab

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Introduction:Struma ovarii is an ovarian teratoma, represented in more than 50% by thyroid tissue. Five percent of struma ovarii cases have been proven to be malignant and, as in the thyroid gland, papillary thyroid carcinoma is the most common histotype arising in struma ovarii. Because of the unusual occurrence of this tumor, its management and follow-up after pelvic surgery is still controversial. Usually, total thyroidectomy followed by radioiodine treatment is the choice treatment in metastatic malignant struma ovarii, while these procedures are still controversial in non-metastatic thyroid cancer arising in struma ovarii.Case Presentation:We report a female with follicular variant of papillary thyroid carcinoma arising in struma ovarii. After pelvic surgery, thyroid morphofunctional examinations were performed and a single nodular lesion in the left lobe was discovered. The patient underwent total thyroidectomy and histological examination showed a papillary carcinoma. Radioiodine-ablation of residual thyroid tissue was performed and levothyroxine mildly-suppressive treatment was started.Conclusions:A more aggressive treatment should not be denied for malignant struma ovarii without any evidence, even when apparently confined into the ovary. However, in selected cases, aggressive treatment may be advisable to decrease the risk of recurrence and to allow an accurate follow-up.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Case Report of Thyroid Carcinoma Confined To Ovary And Concurrently Occult in The Thyroid: Is Conservative Treatment Always Advised?

Brusca¹,

Duca²,

Salvatori

et al. 2014

Int J Endocrinol Metab

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“…NS, characterized by heavy proteinuria, hypoalbuminemia and hyperlipidemia, often leads to progressive loss of kidney function, accounting for ~15 % of end-stage renal disease (ESRD). The cost to health care exceeds $3 billion in the U.S. annually [ 4 , 5 ]. FSGS accounts for 7-20 % of idiopathic NS in children and 40 % in adults and is the most common glomerular disease leading to ESRD in African Americans (AAs) [ 6 , 7 ].…”

Section: Reviewmentioning

confidence: 99%

Focal segmental glomerulosclerosis: molecular genetics and targeted therapies

Chen

Liapis

2015

BMC Nephrol

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Recent advances show that human focal segmental glomerulosclerosis (FSGS) is a primary podocytopathy caused by podocyte-specific gene mutations including NPHS1, NPHS2, WT-1, LAMB2, CD2AP, TRPC6, ACTN4 and INF2. This review focuses on genes discovered in the investigation of complex FSGS pathomechanisms that may have implications for the current FSGS classification scheme. It also recounts recent recommendations for clinical management of FSGS based on translational studies and clinical trials. The advent of next-generation sequencing promises to provide nephrologists with rapid and novel approaches for the diagnosis and treatment of FSGS. A stratified and targeted approach based on the underlying molecular defects is evolving.

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“…The criteria that help to exclude this diagnosis are: (1) lack of personal history of thyroid cancer, (2) unilateral location in the ovary, and (3) absence of teratomatous ovarian tissue [3,8]. Thyroid FNA gives us a definitive diagnosis if necessary.…”

mentioning

confidence: 99%

The lack of consensus in management of malignant struma ovarii

Aguilera

Vázquez

Herguido

et al. 2014

Gynecological Endocrinology

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Struma ovarii is a rare variant of teratoma characterized by the presence of thyroid tissue in more than 50%. Malignant transformation is rare (less than 5%) and the criteria to classify this condition have changed over time. Nowadays it must fulfill the histological categories of differentiated thyroid carcinoma. Its treatment is controversial and there is no unanimous management. We present three cases of women with malignant struma ovarii, diagnosed by the surgical specimen.

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Delayed Treatment of Papillary Thyroid Carcinoma Arising from Struma Ovarii in a Patient with History of Bilateral Salpingo-Oophorectomy: A Case Report

Cited by 11 publications

References 15 publications

A Case Report of Thyroid Carcinoma Confined To Ovary And Concurrently Occult in The Thyroid: Is Conservative Treatment Always Advised?

A Case Report of Thyroid Carcinoma Confined To Ovary And Concurrently Occult in The Thyroid: Is Conservative Treatment Always Advised?

Focal segmental glomerulosclerosis: molecular genetics and targeted therapies

The lack of consensus in management of malignant struma ovarii

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