2006
DOI: 10.1523/jneurosci.0647-06.2006
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Delayed Upregulation of ATP P2X3 Receptors of Trigeminal Sensory Neurons by Calcitonin Gene-Related Peptide

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Cited by 160 publications
(192 citation statements)
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“…However, as expected, they exhibited antagonistic activity on P2X3 receptors, since their application inhibited subsequent current responses evoked by 2 s pulses of 10 μM α,β-meATP (Fig. 4) [37,42,43]. Such inhibition was reversible, as the peak current amplitude fully or partially recovered after 5 min wash out.…”
Section: Biological Assayssupporting
confidence: 72%
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“…However, as expected, they exhibited antagonistic activity on P2X3 receptors, since their application inhibited subsequent current responses evoked by 2 s pulses of 10 μM α,β-meATP (Fig. 4) [37,42,43]. Such inhibition was reversible, as the peak current amplitude fully or partially recovered after 5 min wash out.…”
Section: Biological Assayssupporting
confidence: 72%
“…Newly synthesized compounds 3, 4 and 7-10 were tested for their biological activity at native mouse P2X3 receptors expressed by TG sensory neurons in culture by using the patch clamp recording technique as previously reported [37,42,43]. As a first approach, all compounds were applied for 5 min at 10 μM; none of them could elicit functional responses even at concentration of 10 μM, showing lack of agonist properties.…”
Section: Biological Assaysmentioning
confidence: 99%
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“…As a final outcome, recovery from P2X3 receptor desensitization is accelerated, and P2X3 activity is consequently increased [15,16,17]. Moreover, an increased expression of P2X3 receptors in TG neurons was observed upon algogen application in vitro [15,18], or following induction of trigeminalassociated pain in vivo ( Fig. 1) [19,20].…”
Section: Role Of Neuronal P2x Receptors In Nociceptionmentioning
confidence: 96%