Delayed voluntary physical exercise restores “when” and “where” object recognition memory after traumatic brain injury

Martínez-Drudis, Laura; Amorós-Aguilar, Laura; Torras-Garcia, Meritxell; Serra-Elias, Bruna; David, Cristhian; Portell-Cortès, Isabel; Coll-Andreu, Margalida

doi:10.1016/j.bbr.2020.113048

Cited by 14 publications

(7 citation statements)

References 66 publications

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“…This fact was related to their faster learning and better memorization of the maze structure. Likewise, in a recent work by Martínez-Drudis et al [23] , where rats' brains were injured, they began a 25-day program of voluntary aerobic physical exercise eleven days after the injury. The exercise served as a restorer of memory functions damaged by the induced brain injury.…”

Section: Long-term Exercise (Training) Effects On Cognitive Functionmentioning

confidence: 99%

“…Greater difficulties exist when trying to investigate the physiological effects of exercise on the human brain due to the high degree of invasiveness that data collection techniques would entail. For this reason, the direct observation of exercise effects on brain's physiology is usually approached with animal studies [23] , while indirect evaluation in humans is usually approached through analysis of blood biomarkers [24] .…”

Section: Introductionmentioning

confidence: 99%

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Can exercise shape your brain? A review of aerobic exercise effects on cognitive function and neuro-physiological underpinning mechanisms

Ferrer-Uris

Ramos

Busquets

et al. 2022

AIMSN

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<abstract> <p>It is widely accepted that physical exercise can be used as a tool for the prevention and treatment of various diseases or disorders. In addition, in the recent years, exercise has also been successfully used to enhance people's cognition. There is a large amount of research that has supported the benefits of physical exercise on human cognition, both in children and adults. Among these studies, some have focused on the acute or transitory effects of exercise on cognition, while others have focused on the effects of regular physical exercise. However, the relation between exercise and cognition is complex and we still have limited knowledge about the moderators and mechanisms underlying this relation. Most of human studies have focused on the behavioral aspects of exercise-effects on cognition, while animal studies have deepened in its possible neuro-physiological mechanisms. Even so, thanks to advances in neuroimaging techniques, there is a growing body of evidence that provides valuable information regarding these mechanisms in the human population. This review aims to analyze the effects of regular and acute aerobic exercise on cognition. The exercise-cognition relationship will be reviewed both from the behavioral perspective and from the neurophysiological mechanisms. The effects of exercise on animals, adult humans, and infant humans will be analyzed separately. Finally, physical exercise intervention programs aiming to increase cognitive performance in scholar and workplace environments will be reviewed.</p> </abstract>

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Section: Long-term Exercise (Training) Effects On Cognitive Functionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Can exercise shape your brain? A review of aerobic exercise effects on cognitive function and neuro-physiological underpinning mechanisms

Ferrer-Uris

Ramos

Busquets

et al. 2022

AIMSN

View full text Add to dashboard Cite

show abstract

“…In all of the TBI animal models studied, nine studies found that exercise increased BDNF levels and/or BDNF mRNA expression, showing that the activation of BDNF-TrkB receptors is crucial in the mechanism of exercise-modulated effects [145][146][147][148][149][150][151][152][153]. However, one study found that exercise regimens with significant stress reactions may not be helpful during the early post-injury phase, resulting in elevated BDNF levels in exercise-treated fluid percussion injury rat TBI models [154].…”

Section: Exercisementioning

confidence: 99%

The Roles of Neurotrophins in Traumatic Brain Injury

Lin

Kuo

Luh

2021

Life

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Neurotrophins are a collection of structurally and functionally related proteins. They play important roles in many aspects of neural development, survival, and plasticity. Traumatic brain injury (TBI) leads to different levels of central nervous tissue destruction and cellular repair through various compensatory mechanisms promoted by the injured brain. Many studies have shown that neurotrophins are key modulators of neuroinflammation, apoptosis, blood–brain barrier permeability, memory capacity, and neurite regeneration. The expression of neurotrophins following TBI is affected by the severity of injury, genetic polymorphism, and different post-traumatic time points. Emerging research is focused on the potential therapeutic applications of neurotrophins in managing TBI. We conducted a comprehensive review by organizing the studies that demonstrate the role of neurotrophins in the management of TBI.

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“…Existing data showed that voluntary exercise or voluntary exercise pre-conditioning facilitated neuroplasticity after TBI via the reduction in the level of inflammatory factors and elevation in the level of brain-derived neurotrophic factor [ 36 , 37 , 38 , 39 , 40 ]. However, other studies showed contradictory effects, depending on the different exercise strategy [ 36 , 37 , 38 , 41 ]. Furthermore, since the heightened stress response occurred within the first two weeks after TBI, the ideal time of voluntary exercise after TBI remains to be determined [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

Voluntary Exercise to Reduce Anxiety Behaviour in Traumatic Brain Injury Shown to Alleviate Inflammatory Brain Response in Mice

et al. 2023

IJMS

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Traumatic brain injury is a leading cause of neuroinflammation and anxiety disorders in young adults. Immune-targeted therapies have garnered attention for the amelioration of TBI-induced anxiety. A previous study has indicated that voluntary exercise intervention following TBI could reduce neuroinflammation. It is essential to determine the effects of voluntary exercise after TBI on anxiety via inhibiting neuroinflammatory response. Mice were randomly divided into four groups (sham, TBI, sham + voluntary wheel running (VWR), and TBI + VWR). One-week VWR was carried out on the 2nd day after trauma. The neurofunction of TBI mice was assessed. Following VWR, anxiety behavior was evaluated, and neuroinflammatory responses in the perilesional cortex were investigated. Results showed that after one week of VWR, neurofunctional recovery was enhanced, while the anxiety behavior of TBI mice was significantly alleviated. The level of pro-inflammatory factors decreased, and the level of anti-inflammatory factors elevated. Activation of nucleotide oligomerization domain-like thermal receptor protein domain associated protein 3 (NLRP3) inflammasome was inhibited significantly. All these alterations were consistent with reduced microglial activation at the perilesional site and positively correlated with the amelioration of anxiety behavior. This suggested that timely rehabilitative exercise could be a useful therapeutic strategy for anxiety resulting from TBI by targeting neuroinflammation.

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Delayed voluntary physical exercise restores “when” and “where” object recognition memory after traumatic brain injury

Cited by 14 publications

References 66 publications

Can exercise shape your brain? A review of aerobic exercise effects on cognitive function and neuro-physiological underpinning mechanisms

Can exercise shape your brain? A review of aerobic exercise effects on cognitive function and neuro-physiological underpinning mechanisms

The Roles of Neurotrophins in Traumatic Brain Injury

Voluntary Exercise to Reduce Anxiety Behaviour in Traumatic Brain Injury Shown to Alleviate Inflammatory Brain Response in Mice

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