Delays in Manual Reaching Are Associated with Impaired Functional Abilities in Early Dementia Patients

Boer, Casper de; Pel, J.J.M.; Steen, J. van der; Mattace-Raso, Francesco

doi:10.1159/000377674

Cited by 7 publications

(5 citation statements)

References 30 publications

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“…Although some cross-sectional [114,115] and longitudinal evidence [115] exist about a decreased speed in performing ADL-related tasks in PwMCI, a few studies probed the impact of visuomotor skills on functional autonomies. de Boer et al [116] explored the association between deficits of visually-guided reaching movements and IADL in patients with cognitive impairment (i.e., PwAD, PwaMCI, patients with mixed dementia, and individuals with cognitive complaints). In this study, participants who showed a loss of autonomy in at least two IADL domains took more time in initiating and executing hand movements compared with participants who reported no signs of functional decline.…”

Section: Insights Into the Relationship Binding Visuomotor And Execut...mentioning

confidence: 99%

Hand movements in Mild Cognitive Impairment: clinical implications and insights for future research

Ilardi¹,

Iavarone²,

Marra³

et al. 2022

J. Integr. Neurosci.

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Decreased upper-extremity/visuomotor abilities are frequently encountered in healthy aging. However, few studies have assessed hand movements in the prodromal stage of dementia. The evaluation of visuomotor skills in patients with Mild Cognitive Impairment (PwMCI) may have non-negligible clinical relevance both in diagnostic and prognostic terms, given the strong relationships with executive functioning and functional autonomies. In the present review paper, these issues will be disclosed by describing general pathophysiological and neuropsychological mechanisms responsible for visuomotor deficits, and by reporting the available experimental results on differences in visuomotor functioning between PwMCI, healthy controls and/or patients with dementia. Moreover, the relationships binding visuomotor and executive domains to functional autonomies will be then addressed. Finally, we will propose insights for future research.

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Section: Insights Into the Relationship Binding Visuomotor And Execut...mentioning

confidence: 99%

Hand movements in Mild Cognitive Impairment: clinical implications and insights for future research

Ilardi¹,

Iavarone²,

Marra³

et al. 2022

J. Integr. Neurosci.

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“…One recent study set out to investigate the physical basis of functional decline in older adults and found changes in participants’ muscle function—strength—to explain 40 percent of the variance in age-related functional decline (Maden-Wilkinson et al, 2015). Another study investigating the functional ability of individuals in the early stages of dementia linked manual reaching ability and range of motion with the self-reported loss of function on one or more IADLs (De Boer et al, 2015). Indicators of gait and balance show especially strong associations with functional ability (Albert et al, 2015), as well as long-term longevity (Studenski et al, 2009).…”

Section: The Function Spiral: Backgroundmentioning

confidence: 99%

Investigating the function spiral in later life: Aging attitudes, physical activity, and gait

Whitehead

2017

J Health Psychol

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This study tests the Function Spiral Model, which proposes that functional decline often occurs prematurely: negative aging attitudes reduce activity engagement, which then advances functional decline via physical deconditioning. A total of 89 adults aged 61-96 ( M = 77) years completed a questionnaire assessing aging attitudes and physical activity and participated in a follow-up assessment of gait/balance and function. Results supported the process model: physical activity mediated the impact of negative aging attitudes on gait/balance, and gait/balance mediated the impact of physical activity on function. Findings highlight multiple points of intervention that could mitigate the acceleration of functional decline in later life.

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“…Some patient populations show an impaired ability to successfully perform non-standard visuomotor tasks, even while their performance on standard mapping tasks remains unaffected. These impairments have been observed in patients with mild cognitive impairment (Salek et al, 2011), in the early stages of dementia due to AD (Tippett et al, 2012;de Boer et al, 2014de Boer et al, , 2015de Boer et al, , 2016, and in individuals at an increased risk for future dementia (due to a dementia family history, or a genetic risk due to being an APOE e4 carrier) who did not yet show any cognitive deficits (Hawkins and Sergio, 2014;Lu et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Differences in structural MRI and diffusion tensor imaging underlie visuomotor performance declines in older adults with an increased risk for Alzheimer’s disease

Rogojin

Gorbet

Hawkins

et al. 2023

Front. Aging Neurosci.

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IntroductionVisuomotor impairments have been demonstrated in preclinical AD in individuals with a positive family history of dementia and APOE e4 carriers. Previous behavioral findings have also reported sex-differences in performance of visuomotor tasks involving a visual feedback reversal. The current study investigated the relationship between grey and white matter changes and non-standard visuomotor performance, as well as the effects of APOE status, family history of dementia, and sex on these brain-behavior relationships.MethodsOlder adults (n = 49) with no cognitive impairments completed non-standard visuomotor tasks involving a visual feedback reversal, plane-change, or combination of the two. Participants with a family history of dementia or who were APOE e4 carriers were considered at an increased risk for AD. T1-weighted anatomical scans were used to quantify grey matter volume and thickness, and diffusion tensor imaging measures were used to quantify white matter integrity.ResultsIn APOE e4 carriers, grey and white matter structural measures were associated with visuomotor performance. Regression analyses showed that visuomotor deficits were predicted by lower grey matter thickness and volume in areas of the medial temporal lobe previously implicated in visuomotor control (entorhinal and parahippocampal cortices). This finding was replicated in the diffusion data, where regression analyses revealed that lower white matter integrity (lower FA, higher MD, higher RD, higher AxD) was a significant predictor of worse visuomotor performance in the forceps minor, forceps major, cingulum, inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus (ILF), superior longitudinal fasciculus (SLF), and uncinate fasciculus (UF). Some of these tracts overlap with those important for visuomotor integration, namely the forceps minor, forceps major, SLF, IFOF, and ILF.ConclusionThese findings suggest that measuring the dysfunction of brain networks underlying visuomotor control in early-stage AD may provide a novel behavioral target for dementia risk detection that is easily accessible, non-invasive, and cost-effective. The results also provide insight into the structural differences in inferior parietal lobule that may underlie previously reported sex-differences in performance of the visual feedback reversal task.

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Delays in Manual Reaching Are Associated with Impaired Functional Abilities in Early Dementia Patients

Cited by 7 publications

References 30 publications

Hand movements in Mild Cognitive Impairment: clinical implications and insights for future research

Hand movements in Mild Cognitive Impairment: clinical implications and insights for future research

Investigating the function spiral in later life: Aging attitudes, physical activity, and gait

Differences in structural MRI and diffusion tensor imaging underlie visuomotor performance declines in older adults with an increased risk for Alzheimer’s disease

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