Delays in testing as a source of COVID-19 false-negative results

Zimmer, Rudy

doi:10.46747/cfp.6612e298

Cited by 12 publications

(6 citation statements)

References 9 publications

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“…These requirements are not ideal for point-of-care applications. In source-limited settings, particularly in areas far from clinical laboratories, PCR results could be delivered with several days' delay, which significantly hampers the efforts to curb the spread of Mpox [8] , [9] . Thus, there is an urgent demand to upscale molecular diagnostics and develop techniques accessible to all affected communities and at-risk individuals.…”

Section: Introductionmentioning

confidence: 99%

MASTR Pouch: Palm-size lab for point-of-care detection of Mpox using recombinase polymerase amplification and CRISPR technology

Jia¹,

Wang²,

Yu³

et al. 2023

Sensors and Actuators B: Chemical

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Section: Introductionmentioning

confidence: 99%

MASTR Pouch: Palm-size lab for point-of-care detection of Mpox using recombinase polymerase amplification and CRISPR technology

Jia¹,

Wang²,

Yu³

et al. 2023

Sensors and Actuators B: Chemical

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“… 20 Delayed COVID-19 diagnosis is a public health concern because it maintains chains of transmission, can be a source of COVID-19 false-negative results and offers a possible explanation for worse morbidity and mortality outcomes. 32 , 34 , 35 CEE migrant worker status and co-living situation was associated with being asymptomatic, which could indicate higher readiness to submit to testing in absence of symptoms. More likely it reflects underreporting of symptoms due to possible negative financial consequences or participation in pre-emptive testing imposed by employment agencies as part of COVID-19 control measures in CEE migrants.…”

Section: Discussionmentioning

confidence: 98%

Central and Eastern European migrant worker status, co-living situation and SARS-CoV-2 exposure and transmission risk

Boogaard

Hautvast

Timen

et al. 2023

European Journal of Public Health

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Background Central and Eastern European (CEE) migrant workers in essential industries are at higher risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure and transmission. We investigated the relationship of CEE migrant status and co-living situation with indicators of SARS-CoV-2 exposure and transmission risk (ETR), aiming to find entry points for policies to reduce health inequalities for migrant workers. Methods We included 563 SARS-CoV-2-positive workers between October 2020 and July 2021. Data on ETR indicators were obtained from source- and contact-tracing interviews via retrospective analysis of medical records. Associations of CEE migrant status and co-living situation with ETR indicators were analyzed using chi-square tests and multivariate logistic regression analyses. Results CEE migrant status was not associated with occupational ETR but was with higher occupational-domestic exposure [odds ratio (OR) 2.92; P = 0.004], lower domestic exposure (OR 0.25, P < 0.001), lower community exposure (OR 0.41, P = 0.050) and transmission (OR 0.40, P = 0.032) and higher general transmission (OR 1.76, P = 0.004) risk. Co-living was not associated with occupational and community ETR but was with higher occupational-domestic exposure (OR 2.63, P = 0.032), higher domestic transmission (OR 17.12, P < 0.001) and lower general exposure (OR 0.34, P = 0.007) risk. Conclusions The workfloor poses an equal SARS-CoV-2 ETR for all workers. CEE migrants encounter less ETR in their community but pose a general risk by delaying testing. When co-living, CEE migrants encounter more domestic ETR. Coronavirus disease preventive policies should aim at occupational safety for essential industry workers, reduction of test delay for CEE migrants and improvement of distancing options when co-living.

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“…This metric is important because time to testing may substantially alter personal and professional decisions to isolate, thus having the potential to impact the spread of infection. Second, delays in testing may also lead to false-negative results . Third, understanding the timeliness of testing allows us to compare subgroups for demographic disparities in testing as well as to identify organizational or structural constraints.…”

Section: Discussionmentioning

confidence: 99%

“…Second, delays in testing may also lead to false-negative results. 16 Third, understanding the timeliness of testing allows us to compare subgroups for demographic disparities in testing as well as to identify organizational or structural constraints. To investigate potential disparities for organizational and structural constraints, we nested our research question within an ongoing, multicenter, vaccine effectiveness case-control study of HCP who have access to routine testing and largely understand the risks associated with infection.…”

Section: Discussionmentioning

confidence: 99%

Race, Ethnicity, and Delayed Time to COVID-19 Testing Among US Health Care Workers

Baymon,

Vakkalanka,

Krishnadasan

et al. 2024

JAMA Netw Open

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ImportanceAccess to COVID-19 testing is critical to reducing transmission and supporting early treatment decisions; when made accessible, the timeliness of testing may also be an important metric in mitigating community spread of the infection. While disparities in transmission and outcomes of COVID-19 have been well documented, the extent of timeliness of testing and the association with demographic factors is unclear.ObjectivesTo evaluate demographic factors associated with delayed COVID-19 testing among health care personnel (HCP) during the COVID-19 pandemic.Design, Setting, and ParticipantsThis cross-sectional study used data from the Preventing Emerging Infections Through Vaccine Effectiveness Testing study, a multicenter, test-negative, case-control vaccine effectiveness study that enrolled HCP who had COVID-19 symptoms and testing between December 2020 and April 2022. Data analysis was conducted from March 2022 to Junne 2023.ExposureDisplaying COVID-19–like symptoms and polymerase chain reaction testing occurring from the first day symptoms occurred up to 14 days after symptoms occurred.Main Outcomes and MeasuresVariables of interest included patient demographics (sex, age, and clinical comorbidities) and COVID-19 characteristics (vaccination status and COVID-19 wave). The primary outcome was time from symptom onset to COVID-19 testing, which was defined as early testing (≤2 days) or delayed testing (≥3 days). Associations of demographic characteristics with delayed testing were measured while adjusting for clinical comorbidities, COVID-19 characteristics, and test site using multivariable modeling to estimate relative risks and 95% CIs.ResultsA total of 5551 HCP (4859 female [82.9%]; 1954 aged 25-34 years [35.2%]; 4233 non-Hispanic White [76.3%], 370 non-Hispanic Black [6.7%], and 324 non-Hispanic Asian [5.8%]) were included in the final analysis. Overall, 2060 participants (37.1%) reported delayed testing and 3491 (62.9%) reported early testing. Compared with non-Hispanic White HCP, delayed testing was higher among non-Hispanic Black HCP (adjusted risk ratio, 1.18; 95%CI, 1.10-1.27) and for non-Hispanic HCP of other races (adjusted risk ratio, 1.17; 95% CI, 1.03-1.33). Sex and age were not associated with delayed testing. Compared with clinical HCP with graduate degrees, all other professional and educational groups had significantly delayed testing.Conclusions and RelevanceIn this cross-sectional study of HCP, compared with non-Hispanic White HCP and clinical HCP with graduate degrees, non-Hispanic Black HCP, non-Hispanic HCP of other races, and HCP all other professional and education backgrounds were more likely to have delayed COVID-19 testing. These findings suggest that time to testing may serve as a valuable metric in evaluating sociodemographic disparities in the response to COVID-19 and future health mitigation strategies.

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Delays in testing as a source of COVID-19 false-negative results

Cited by 12 publications

References 9 publications

MASTR Pouch: Palm-size lab for point-of-care detection of Mpox using recombinase polymerase amplification and CRISPR technology

MASTR Pouch: Palm-size lab for point-of-care detection of Mpox using recombinase polymerase amplification and CRISPR technology

Central and Eastern European migrant worker status, co-living situation and SARS-CoV-2 exposure and transmission risk

Race, Ethnicity, and Delayed Time to COVID-19 Testing Among US Health Care Workers

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