Deletion 20q in association with Philadelphia chromosome positive acute lymphoblastic leukemia

Hollings, Peter E.; Benjes, Suzanne M.; Rosman, Ingrid; Fitzgerald, P. H.

doi:10.1016/0165-4608(94)00068-m

Cited by 13 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cytogenetic analysis demonstrated that the ALL and RAEB clones in our patient shared a 20qÿ abnormality, providing clonal progression from MDS to ALL. Although the 20qÿ abnormality is assumed to be primarily associated with myeloid disorders (Aatola et al, 1992), two patients have been described, with Ph 1 -positive ALL and 20qÿ abnormalities (Hollings et al, 1995). Studies of these patients and ours suggest that the 20qÿ clone originates in a pluripotent stem cell with the capacity to differentiate into both myeloid and lymphoid lineage.…”

Section: Discussionmentioning

confidence: 49%

Progression from myelodysplastic syndrome to acute lymphoblastic leukaemia with Philadelphia chromosome and p190 BCR‐ABL transcript

et al. 1996

View full text Add to dashboard Cite

We describe a patient with Philadelphia chromosome (Ph1)-positive acute lymphoblastic leukaemia (ALL) who developed it 2.5 years after being diagnosed with myelodysplastic syndrome (MDS). The patient initially had refractory anaemia (RA), but progressed to refractory anaemia with excess blasts (RAEB) 2 years later, that terminated in ALL. An immunophenotypic analysis of the lymphoblasts revealed CD10 and CD19 positive cells. The karyotype was normal 46,XY in RA phase, 46,XY,20q-during the RAEB phase, and 46,XY,t(9;22)(q34;q11),20q-during the ALL phase. Furthermore, p190 BCR-ABL mRNA was detected in the ALL blasts. These findings indicate that this ALL arose from the MDS clone through multiple cytogenetic evolutions, the final event of which was the acquisition of p190 BCR-ABL type Ph1.

show abstract

Section: Discussionmentioning

confidence: 49%

Progression from myelodysplastic syndrome to acute lymphoblastic leukaemia with Philadelphia chromosome and p190 BCR‐ABL transcript

et al. 1996

View full text Add to dashboard Cite

show abstract

“…Our cytogenetic analysis suggests that del(20q12) is significantly associated with HT of NMZL to DLBCL. That 4/6 tNMZL cases have del(20q12) >20% is remarkable considering the rarity of del(20q) in lymphomas, although early studies found an association with “diffuse small cleaved cell lymphomas.” Other reports of del(20q12) in lymphoma include lymphoplasmacytic lymphoma/Waldenström macroglobulinemia, acute lymphoblastic leukemia (ALL), and AILD‐like T‐cell lymphoma . Del(20q) is a therapy‐related abnormality in chronic lymphocytic leukemia (CLL) that involves both the myeloid and lymphoid lineages and may represent disease progression .…”

Section: Discussionmentioning

confidence: 99%

Deletion 20q12 is associated with histological transformation of nodal marginal zone lymphoma to diffuse large B‐cell lymphoma

et al. 2019

View full text Add to dashboard Cite

The genetic and molecular abnormalities underlying histological transformation (HT) of nodal marginal zone lymphoma (NMZL) to diffuse large B-cell lymphoma (DLBCL) are not well known. While del(20q12) is commonly deleted in myelodysplastic syndrome it has not previously been associated with DLBCL. We recently described a case of DLBCL harboring del(20q12) in a patient with a history of MZL involving lymph nodes and skin. Here we report eight matched cases of transformed MZL(tMZL): six from nodal MZL (tNMZL) and two from splenic MZL (tSMZL). We found >20% del(20q12) in 4/6 tNMZL, but not in tSMZL, nor in unmatched DLBCL, MZL with increased large cells (MZL-ILC), or MZL cases. To examine whether transformation is associated with a specific gene signature, the matched cases were analyzed for multiplexed gene expression using the Nanostring PanCancer Pathways panel. The differential gene expression signature revealed enrichment of inflammatory markers, as previously observed in MZL. Also, tMZL and de novo DLBCL were enriched for extracellular matrix proteins such as collagen and fibronectin, vascular development protein PDGFRβ, DNA repair protein RAD51, and oncogenic secrete protein Wnt11. A subset of genes is expressed differentially in del(20q12) tMZL cases vs non-del(20q12) tMZL cases. These results suggest a specific pathway is involved in the histological transformation of NMZL, which could serve as an indicator of aggressive clinical course in this otherwise indolent neoplasm.

show abstract

“…(Key words: Cytogenetics; Del(20q); Bone marrow; Myeloproliferative disorders; Myelodysplastic syndromes; Acute leukemia) Am J Clin Pathol 1996; 106:680-688. mary karyotypic abnormality in acute myeloid leukemias, 10 "' 33 " 37 and to our knowledge, there have been only three cases of 20q-occurring in phenotypically confirmed de novo acute lymphoblastic leukemia. 38 ' 39 Finally, there have been individual cases of small lymphocytic lymphoma of B-cell type, 40 diffuse small cleaved cell lymphoma, 41 large cell malignant lymphoma, 42 T-cell lymphoma, 43 giant cell osteosarcoma, 44 and meningioma 45 in which the tumor cells had the 20q-chromosomal abnormality.…”

Section: From the Department Of Laboratory Medicine And Pathology DImentioning

confidence: 99%

Hematologic Disorders Associated With Deletions of Chromosome 20q:A Clinicopathologic Study of 107 Patients

et al. 1996

View full text Add to dashboard Cite

show abstract

Deletion 20q in association with Philadelphia chromosome positive acute lymphoblastic leukemia

Cited by 13 publications

References 19 publications

Progression from myelodysplastic syndrome to acute lymphoblastic leukaemia with Philadelphia chromosome and p190 BCR‐ABL transcript

Progression from myelodysplastic syndrome to acute lymphoblastic leukaemia with Philadelphia chromosome and p190 BCR‐ABL transcript

Deletion 20q12 is associated with histological transformation of nodal marginal zone lymphoma to diffuse large B‐cell lymphoma

Hematologic Disorders Associated With Deletions of Chromosome 20q:A Clinicopathologic Study of 107 Patients

Contact Info

Product

Resources

About