Deletion of both chromosome 7 homologues in leiomyoma

Kingsley, Kristine L.; Meloni, Aurelia M.; Sandberg, Andrea A.; Sandberg, Avery A.; Surti, Urvashi

doi:10.1016/s0165-4608(99)80003-x

Cited by 3 publications

(1 citation statement)

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“…The significance of deletions in 7q for the UL karyotype evolution is confirmed by their recurrent emergence as independent clonal events or secondary emergence in cells with pre-existing chromosome abnormalities [ 134 , 136 , 182 , 183 ]. There is also a documented case of a UL with deletions in the long arms of both chromosome 7 homologues [ 184 ].…”

Section: Spectrum Of Somatic Genetic Aberrations In Ul Cellsmentioning

confidence: 99%

A View on Uterine Leiomyoma Genesis through the Prism of Genetic, Epigenetic and Cellular Heterogeneity

Koltsova

Efimova

Pendina

2023

IJMS

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Uterine leiomyomas (ULs), frequent benign tumours of the female reproductive tract, are associated with a range of symptoms and significant morbidity. Despite extensive research, there is no consensus on essential points of UL initiation and development. The main reason for this is a pronounced inter- and intratumoral heterogeneity resulting from diverse and complicated mechanisms underlying UL pathobiology. In this review, we comprehensively analyse risk and protective factors for UL development, UL cellular composition, hormonal and paracrine signalling, epigenetic regulation and genetic abnormalities. We conclude the need to carefully update the concept of UL genesis in light of the current data. Staying within the framework of the existing hypotheses, we introduce a possible timeline for UL development and the associated key events—from potential prerequisites to the beginning of UL formation and the onset of driver and passenger changes.

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