Deletion of Thioredoxin-interacting protein ameliorates high fat diet-induced non-alcoholic steatohepatitis through modulation of Toll-like receptor 2-NLRP3-inflammasome axis: Histological and immunohistochemical study

Mohamed, Islam; Sarhan, Nahla Reda; Eladl, Mohamed Ahmed; El-Remessy, Azza B.; El-Sherbiny, Mohamed

doi:10.1016/j.acthis.2018.02.006

Cited by 25 publications

(22 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Liver, a central detoxifying organ of the body, is also the primary organ regulating gluconeogenesis and lipogenesis (Glaser et al., 2019; Liu et al., 2013; Sunny, Parks, Browning, & Burgess, 2011). The disturbance in intra‐hepatic lipid homeostasis has emerged as a risk factor for the development of liver diseases, such as fat liver and non‐alcoholic steatohepatitis, leading to retarded growth in human and animals (Bechmann et al., 2012; Liu et al., 2013; Mohamed, Sarhan, Eladl, El‐Remessy, & El‐Sherbiny, 2018). Previous in vivo findings have shown that dietary wheat bran fibre or inulin supplementation can improve the growth performance of growing pigs (Chen et al, 2020; Wang et al., 2019; Wu et al., 2018; Zhao et al., 2018).…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary fibres on gut microbial metabolites and liver lipid metabolism in growing pigs

Chen

et al. 2020

Animal Physiology Nutrition

View full text Add to dashboard Cite

This study was conducted to investigate the effects of dietary supplementation with wheat bran fibre, inulin and their combination on growth performance, short‐chain fatty acids (SCFAs) production in caecum and colon and liver lipid metabolism in growing pigs. A total of 48 Duroc × Landrace × Yorkshire cross‐bred growing pigs (73 ± 2 days of age; 24.37 ± 2.86 kg) were allocated to four groups randomly, each group consisting of six pens with two pigs each. The pigs were fed a control diet (CON), a diet containing 2% wheat bran fibre (WB), a diet containing 2% inulin (IN), and a diet containing both of 1% wheat bran fibre and 1% inulin (MIX), respectively. The trial lasted for 28 days. The results showed that MIX fed pigs had a higher percentage of fat in the liver than those fed the CON (p < .05). IN, WB or MIX feeding decreased the concentrations of acetate and total SCFAs in colon compared with CON (p < .01). Feeding WB or IN also decreased the colonic butyrate concentrations compared with CON (p < .01). However, the serum level of valeric acid was elevated in the IN, WB and MIX group (p < .01). MIX fed pigs tended to have lower levels of propionate in serum than the WB fed pigs (p = .098). MIX feeding enhanced the mRNA expression of lipid synthesis‐related genes in liver compared with CON (p < .05). Feeding IN decreased the expression of bile acids synthesis‐related genes in liver and increased mRNA expression of SCFAs transporter SLC16A1 in colon compared with CON (p < .05). In this study, these data indicated that the combined supplementation of wheat bran fibre and inulin decreased the SCFAs concentrations in the colon, enhanced the genes FAS and HNF‐4α mRNA expression in liver and induced liver lipid accumulation in growing pigs.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of dietary fibres on gut microbial metabolites and liver lipid metabolism in growing pigs

Chen

et al. 2020

Animal Physiology Nutrition

View full text Add to dashboard Cite

show abstract

“…The oxidoreductase activity of MIF is closely related to the Trx family. 301,[305][306][307] MKP-1 is an archetypal member of the dual specificity phosphatase family that inactivates the MAPK activity in response to pro-inflammatory stimuli. [308][309][310] MKP-1 is induced by GC to mediate GC inhibition of ERK, JNK and p38MAPK activities and cytokine production induced by proinflammatory stimuli such as LPS or IL-1.…”

Section: Trx and Its Effect In Copdmentioning

confidence: 99%

Progress in the mechanism and targeted drug therapy for COPD

Wang

Zhou

Wang

et al. 2020

Sig Transduct Target Ther

153

117

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is emphysema and/or chronic bronchitis characterised by long-term breathing problems and poor airflow. The prevalence of COPD has increased over the last decade and the drugs most commonly used to treat it, such as glucocorticoids and bronchodilators, have significant therapeutic effects; however, they also cause side effects, including infection and immunosuppression. Here we reviewed the pathogenesis and progression of COPD and elaborated on the effects and mechanisms of newly developed molecular targeted COPD therapeutic drugs. Among these new drugs, we focussed on thioredoxin (Trx). Trx effectively prevents the progression of COPD by regulating redox status and protease/anti-protease balance, blocking the NF-κB and MAPK signalling pathways, suppressing the activation and migration of inflammatory cells and the production of cytokines, inhibiting the synthesis and the activation of adhesion factors and growth factors, and controlling the cAMP-PKA and PI3K/Akt signalling pathways. The mechanism by which Trx affects COPD is different from glucocorticoid-based mechanisms which regulate the inflammatory reaction in association with suppressing immune responses. In addition, Trx also improves the insensitivity of COPD to steroids by inhibiting the production and internalisation of macrophage migration inhibitory factor (MIF). Taken together, these findings suggest that Trx may be the ideal drug for treating COPD.

show abstract

“…nip) expression significantly increased in the mammary glands of dams consuming an HFD. Although no work has been done specifically addressing an HFD, Txnip, and the mammary gland, studies have shown that deletion of Txnip is able to ameliorate HFD-induced hepatic lipogenesis (38,42). Similarly, a recent mouse study found that Txnip activation results in interleukin-1␤ (IL-1␤) secretion.…”

Section: High-fat Diet Impacts Peak Lactation Mammary Glandmentioning

confidence: 99%

Effect of high-fat diet feeding and associated transcriptome changes in the peak lactation mammary gland in C57BL/6 dams

Cheng

Hernández

2018

Physiological Genomics

View full text Add to dashboard Cite

Maternal consumption of a high-fat diet (HFD) during pregnancy has established adverse effects on the developing neonate. In this study, we aimed to investigate the effect of an HFD on the murine mammary gland during midlactation. Female C57BL/6J mice were placed on either a low-fat diet (LFD/10% fat) or HFD (60% fat) from 3 wk of age through peak lactation (lactation day 11/L11). After 4 wk of consuming either the LFD or HFD, female mice were bred. There were no significant differences in milk yield between treatment groups, which was measured from L1 to L9. On L10, mice were subjected to an overnight fast and then euthanized on the morning of L11. Total RNA was isolated from inguinal mammary glands for whole transcriptome sequencing. We found 628 genes that were differentially expressed between the treatment groups. Notably, HFD feeding resulted in expression alterations of genes involved in collagen and cytoplasmic components. Additionally, genes related to inflammatory and immune responses were also impacted. Differential expression in gene transcript isoforms between the treatment groups was detected in three genes related to mammary duct development. This study sheds light as to how an HFD may affect the mammary gland transcriptome during midlactation.

show abstract

Deletion of Thioredoxin-interacting protein ameliorates high fat diet-induced non-alcoholic steatohepatitis through modulation of Toll-like receptor 2-NLRP3-inflammasome axis: Histological and immunohistochemical study

Cited by 25 publications

References 52 publications

Effects of dietary fibres on gut microbial metabolites and liver lipid metabolism in growing pigs

Effects of dietary fibres on gut microbial metabolites and liver lipid metabolism in growing pigs

Progress in the mechanism and targeted drug therapy for COPD

Effect of high-fat diet feeding and associated transcriptome changes in the peak lactation mammary gland in C57BL/6 dams

Contact Info

Product

Resources

About