Delftia acidovorans: A rare cause of septic pulmonary embolism from catheter-related infection: Case report and literature review

Patel, Dharmendrakumar A.; Iqbal, Arshad Muhammad; Mubarik, Ateeq; Vassa, Nirali; Godil, Rania; Saad, Mohamad S.; Muddassir, Salman

doi:10.1016/j.rmcr.2019.100835

Cited by 16 publications

(14 citation statements)

References 14 publications

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“…were found with an abundance of almost 6% and 2%, respectively. Delftia acidovorans is usually not pathogenic, but catheter-related bacteremia and cases of pneumonia with lung cavity formation has been observed ( 23, 24 ).…”

Section: Resultsmentioning

confidence: 99%

Prevalence of bacterial pathogens and potential role in COVID-19 severity in patients admitted to intensive care units in Brazil

Carvalho

Lemos

Ciapina

et al. 2020

Preprint

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Secondary bacterial and fungal infections are associated with respiratory viral infections and invasive mechanical ventilation. In Coronavirus disease 2019 (COVID-19), lung injury by SARS-CoV-2 and impaired immune response can provide a favorable environment for microorganism growth and colonization in hospitalized individuals. Recent studies suggest that secondary bacterial pneumonia is a risk factor associated with COVID-19. In Brazil, knowledge about microbiota present in COVID-19 patients is incipient. This work describes the microbiota of 21 COVID-19 patients admitted to intensive care units from two Brazilian centers. We identified respiratory, nosocomial and bacterial pathogens as prevalent microorganisms. Other bacterial opportunistic and commensal species are also represented. Virulence factors of these pathogenic species, metabolic pathways used to evade and modulate immunological processes and the interconnection between bacterial presence and virulence in COVID-19 progression are discussed.Article Summary LineWe identified respiratory, nosocomial and bacterial pathogens as prevalent microorganisms in 21 Brazilian COVID-19 patients admitted to Intensive Care Units. Pathogen virulence factors and immune response evasion metabolic pathways are correlated to COVID-19 severity.

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Section: Resultsmentioning

confidence: 99%

Prevalence of bacterial pathogens and potential role in COVID-19 severity in patients admitted to intensive care units in Brazil

Carvalho

Lemos

Ciapina

et al. 2020

Preprint

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“…Nor is it well understood whether the presence of Delftia in water systems is problematic or potentially beneficial. Like many bacterial taxa, Delftia species are recorded as opportunistic pathogens that can infect hospitalized or immunocompromised patients (Patel et al, 2019) (Bilgin et al, 2015. However, there is no indication that human bodies are a common habitat for this genus.…”

Section: Discussionmentioning

confidence: 99%

Catalyzing rapid discovery of gold-precipitating bacterial lineages with university students

Riley

Goller

Leggett

et al. 2020

PeerJ

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Intriguing and potentially commercially useful microorganisms are found in our surroundings and new tools allow us to learn about their genetic potential and evolutionary history. Engaging students from different disciplines and courses in the search for microbes requires an exciting project with innovative but straightforward procedures and goals. Here we describe an interdisciplinary program to engage students from different courses in the sampling, identification and analysis of the DNA sequences of a unique yet common microbe, Delftia spp. A campus-wide challenge was created to identify the prevalence of this genus, able to precipitate gold, involving introductory level environmental and life science courses, upper-level advanced laboratory modules taken by undergraduate students (juniors and seniors), graduate students and staff from the campus. The number of participants involved allowed for extensive sampling while undergraduate researchers and students in lab-based courses participated in the sample processing and analyses, helping contextualize and solidify their learning of the molecular biology techniques. The results were shared at each step through publicly accessible websites and workshops. This model allows for the rapid discovery of Delftia presence and prevalence and is adaptable to different campuses and experimental questions.

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“…This patient with symptoms of lower respiratory tract infection died despite treatment 5 . The reported cases of Delfia infection consist mostly of patients with immunodeficiency 2,16,17 However, there are also cases reported in immunocompetent patients 3,5,18 . Khan et al 3 , reported a case of Delftia acidovorans bacteremia, in a four-year-old immunocompetent patient with pulmonary abscess.…”

Section: Discussionmentioning

confidence: 99%

Delftia Acidovorans pneumonia with lung cavities formation

et al. 2019

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Case Description: A 52-year-old female patient was admitted to our clinic with complaints of cough, sputum, fever and fatigue. The patient has been receiving immunosuppressive therapy for thrombocytopenic purpura for 5 years. Clinical Finding: Inspiratory crackles were heard on both hemithorax. Oxygen saturation measured with the pulse oximeter was 97%. Chest X-ray showed diffuse reticular opacities that were more prominent in the upper zones of both lungs. WBC counts were 17600/mm3 and Platelet counts were 29000/mm3. Thorax CT showed that there were many thin-walled cavities and millimetric nodules accompanied by ground-glass infiltrates in the upper and middle lobes. Gram staining of bronchial fluid, taken by bronchoscopy, revealed Gram-negative bacilli and intense polymorphonuclear leukocytes. The bacteria were defined as Delftia acidovorans by BD Phoenix automated system. Treatment and outcomes: The patient was hospitalized with suspicion of opportunistic pulmonary infections and cavitary lung disease. After the empirical treatment of intravenous piperacillin-tazobactam and oral clarithromycin, her clinical and radiological findings significantly regressed, and she was discharged with outpatient follow-up. Clinical Relevance: This is the first example of cavitary pneumonia due to Delftia acidovorans in an immunocompromised patient. We would like to emphasize that Delftia pneumonia should be considered in the differential diagnosis of pulmonary cavitary involvement in such patients.

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Delftia acidovorans: A rare cause of septic pulmonary embolism from catheter-related infection: Case report and literature review

Cited by 16 publications

References 14 publications

Prevalence of bacterial pathogens and potential role in COVID-19 severity in patients admitted to intensive care units in Brazil

Prevalence of bacterial pathogens and potential role in COVID-19 severity in patients admitted to intensive care units in Brazil

Catalyzing rapid discovery of gold-precipitating bacterial lineages with university students

Delftia Acidovorans pneumonia with lung cavities formation

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