Delineating the Mechanism of Alzheimer’s Disease Aβ Peptide Neurotoxicity

Cappai, Roberto; Barnham, Kevin J.

doi:10.1007/s11064-007-9469-8

Cited by 102 publications

(78 citation statements)

References 106 publications

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“…The amyloid hypothesis has undergone several modifications, mainly concerning the type of A␤ thought to cause AD: initially this was the amyloid plaque, followed by increased concentrations of A␤ 42 , then increased A␤ 42 : A␤ 40 ratio, and finally oligomeric A␤ [2]. Results from clinical trials have shown that removing plaques will not reverse the damage or stop AD [3,4]. Recent evidence suggests that this toxicity may be linked to the aggregation state of the peptide, implicating oligomers, rather than insoluble fibrils, as the primary toxic species [5,6].…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanisms of Amyloid Oligomers Toxicity

Kayed

Lasagna‐Reeves

2012

JAD

326

283

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Abstract. Amyloid oligomers have emerged as the most toxic species of amyloid-␤ (A␤). This hypothesis might explain the lack of correlation between amyloid plaques and memory impairment or cellular dysfunction. However, despite the numerous published research articles supporting the critical role A␤ oligomers in synaptic dysfunction and cell death, the exact definition and mechanism of amyloid oligomers formation and toxicity still elusive. Here we review the evidence supporting the many molecular mechanisms proposed for amyloid oligomers toxicity and suggest that the complexity and dynamic nature of amyloid oligomers may be responsible for the discrepancy among these mechanisms and the proposed cellular targets for amyloid oligomers.

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Section: Introductionmentioning

confidence: 99%

Molecular Mechanisms of Amyloid Oligomers Toxicity

Kayed

Lasagna‐Reeves

2012

JAD

326

283

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“…The various experimental studies reported the role of rich feeding from anti-inflammations and anti-oxidants in recovery of neuro toxicity and recovery of the act of the brain (Cappai and et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Effect of Borage on hipocampal TNF-α protein and gene in the Amyloid β-Peptide(25–35)-Induced of Alzheimer model in rat

Barati¹,

Asl²,

Pourbakhsh³

et al. 2016

Biosci., Biotech. Res. Asia

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Alzheimer's disease (AD) is a neurodegenerative disorder and most common form of dementia that leads to memory impairment. In the present study we have examined the investigating effect of Borago officinale on hipocampal TNF-α α α α α protein in the Beta Amyloid peptid induced of inflammation in the rat. Wistar male rats received intrahippocampal (IHP) injection of the Aβ β β β β(25-35) and borage extract orally (100 mg/ kg).inflamation was confirmed by pathologist.in order to measure the expression of the TNF-α α α α α gene , RT-PCR method and for extraction of the TNF-α α α α α protein western bloting method was used. results showed that using Borage lead to reduce TNF-α α α α α gene and protein. This data suggests that borage could improve the reduction of inflammation factors such as TNF-α α α α α and borage consumption may lead to an improvement of ADinduced cognitive dysfunction.

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“…This was the case despite Y10A mutant producing H 2 O 2 at half the rate of that by the wild-type peptide. Cappai and Barnham (2008) proposed that the covalently cross-linked oligomers produced by this Cu(II) catalyzed redox process is the genesis of -induced neurotoxicity. Hence, it is possible that the Cu(II)/redox chemistry initiates the generation of toxic soluble oligomers (which are toxic by mechanisms as of yet undetermined) rather than the neurodegeneration in AD being directly the result of the ROS generation.…”

Section: Copper and Amyloid Betamentioning

confidence: 99%

Structural and Computational Studies of Interactions of Metals with Amyloid Beta

Epa¹

2012

Neurodegeneration

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Delineating the Mechanism of Alzheimer’s Disease Aβ Peptide Neurotoxicity

Cited by 102 publications

References 106 publications

Molecular Mechanisms of Amyloid Oligomers Toxicity

Molecular Mechanisms of Amyloid Oligomers Toxicity

Effect of Borage on hipocampal TNF-α protein and gene in the Amyloid β-Peptide(25–35)-Induced of Alzheimer model in rat

Structural and Computational Studies of Interactions of Metals with Amyloid Beta

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