Delineation of Experimental Liver Tumors in Rabbits by a New Ultrasound Contrast Agent and Stimulated Acoustic Emission

Hauff, Peter; Fritzsch, T.; Reinhardt, Michaël; Lüders, F.; Uhlendorf, V.; Heldmann, Dieter

doi:10.1097/00004424-199702000-00004

Cited by 74 publications

(17 citation statements)

References 15 publications

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“…This now is a signal which is solely dependent on the presence of the substance, but no more on its velocity or on vessel calibre. Shortly after injection, it acts as a blood pool agent, whereas later it is stored in the reticulo-endothelial system and may thereby serve as a liver-specific contrast agent [77].…”

Section: Perspectivesmentioning

confidence: 99%

Non-invasive vascular imaging: assessing tumour vascularity

1998

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Non-invasive assessment of vascularity is a new diagnostic approach to characterise tumours. Vascular assessment is based on the pathophysiology of tumour angiogenesis and its diagnostic implications for tumour biology, prognosis and therapy response. Two current techniques investigating vascular features in addition to morphology are Doppler ultrasonography and contrast-enhanced MRI. Diagnostic differentiation has been shown to be possible with Doppler, and a high degree of observed vascularity could be linked to an aggressive course of the disease. Dynamic MRI using gadolinium chelates is already used clinically to detect and differentiate tumours. The histological correlation shows that capillary permeability is increased in malignant tumours and is the best criterion for differentiation from benign processes. Permeability and perfusion factors seem to be more diagnostic than overall vessel density. New clinical applications are currently being established for therapy monitoring. Further instrumental developments will bring harmonic imaging in Doppler, and faster imaging techniques, higher spatial resolution and novel pharmacokinetic concepts in MRI. Upcoming contrast agents for both Doppler and MRI will further improve estimation of intratumoural blood volume and vascular permeability.

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Section: Perspectivesmentioning

confidence: 99%

Non-invasive vascular imaging: assessing tumour vascularity

1998

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“…In an ex vivo approach, we specifically depicted the molecular pattern of ICAM-1 expression during autoimmune inflammation of the CNS with high sensitivity [7]. This method is based on a specific acoustic property of gasfilled MP, the stimulated acoustic emission effect (SAE) which allows visualization of MP in a color-coded 2D image [8]. Based on the SAE effect, we recently developed a method for the reliable quantification of ultrasound contrast media termed sensitive particle acoustic quantification (SPAQ) [9].…”

Section: Introductionmentioning

confidence: 99%

In vivo molecular imaging of adhesion molecules in experimental autoimmune encephalomyelitis (EAE)

Linker

Reinhardt²,

Bendszus

et al. 2005

Journal of Autoimmunity

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“…The implantation method used has been described elsewhere [17] . Only part of tumor tissue showing no macroscopic signs of necrosis was used.…”

Section: Animal Modelmentioning

confidence: 99%

Assessment of hepatic VX2 tumors with combined percutaneous transhepatic lymphosonography and contrast-enhanced ultrasonographic imaging

Liu

Liang²,

Wang³

et al. 2008

WJG

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CONCLUSION: PTL is a novel method for the detection of tumor lymphangiogenesis in hepatic VX 2 of rabbits. Combined PTL and contrast-enhanced ultrasonographic imaging can improve the diagnosis of liver cancer.© 2008 The WJG Press. All rights reserved. Key words:Percutaneous transhepatic lymphosonography; Ultrasound; Contrast-enhanced ultrasonographic imaging; Ultrasound contrast media; VX 2 tumor Peer reviewer: Gianluigi Giannelli, MD, Dipartimento di Clinica Medica, Immunologia e Malattie Infettive, Sezione di Medicina Interna, Policlinico, Piazza G. Cesare 11, Bari 70124, Italy Liu C, Liang P, Wang Y, Zhou P, Li X, Han ZY, Liu SP. Assessment of hepatic VX 2 tumors with combined percutaneous transhepatic lymphosonography and contrast-enhanced ultrasonographic imaging.

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Delineation of Experimental Liver Tumors in Rabbits by a New Ultrasound Contrast Agent and Stimulated Acoustic Emission

Abstract: SH U 563 A, combined with stimulated acoustic emission, provides potential for delineation of small isoechogenic liver lesions by sonography.

Cited by 74 publications

References 15 publications

Non-invasive vascular imaging: assessing tumour vascularity

Non-invasive vascular imaging: assessing tumour vascularity

In vivo molecular imaging of adhesion molecules in experimental autoimmune encephalomyelitis (EAE)

Assessment of hepatic VX2 tumors with combined percutaneous transhepatic lymphosonography and contrast-enhanced ultrasonographic imaging

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