Delivery of genome editing tools: A promising strategy for HPV-related cervical malignancy therapy

Aghamiri, Seyed Mahmoud Reza; Talaei, Sam; Roshanzamiri, Soheil; Zandsalimi, Farshid; Fazeli, Elnaz; Aliyu, Mansur; Avarvand, Omid Kheiry; Ebrahimi, Zahra; Keshavarz-Fathi, Mahsa; Ghanbarian, Hossein

doi:10.1080/17425247.2020.1747429

Cited by 26 publications

(22 citation statements)

References 137 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ZFNs targeting HPV16 and 18 induced in vitro E7 interruption and inhibition of type-specific and efficient growth and apoptosis of HPV-positive cells. These targeted ZFNs may be possible new therapeutic agents for the treatment of HPV-related cervical cancer [ 151 , 152 , 153 ].…”

Section: Immunotherapymentioning

confidence: 99%

Immunotherapy and Gene Therapy for Oncoviruses Infections: A Review

Almeida

Ribeiro

Raposo

et al. 2021

Viruses

View full text Add to dashboard Cite

Immunotherapy has been shown to be highly effective in some types of cancer caused by viruses. Gene therapy involves insertion or modification of a therapeutic gene, to correct for inappropriate gene products that cause/may cause diseases. Both these types of therapy have been used as alternative ways to avoid cancers caused by oncoviruses. In this review, we summarize recent studies on immunotherapy and gene therapy including the topics of oncolytic immunotherapy, immune checkpoint inhibitors, gene replacement, antisense oligonucleotides, RNA interference, clustered regularly interspaced short palindromic repeats Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based gene editing, transcription activator-like effector nucleases (TALENs) and custom treatment for Epstein–Barr virus, human T-lymphotropic virus 1, hepatitis B virus, human papillomavirus, hepatitis C virus, herpesvirus associated with Kaposi’s sarcoma, Merkel cell polyomavirus, and cytomegalovirus.

show abstract

Section: Immunotherapymentioning

confidence: 99%

Immunotherapy and Gene Therapy for Oncoviruses Infections: A Review

Almeida

Ribeiro

Raposo

et al. 2021

Viruses

View full text Add to dashboard Cite

show abstract

“…HPV is an oncovirus that causes several cancers, like anal, genital, and oropharyngeal cancers, and elevates the risks of dysplasia and cervical malignancy [129]. HPV is known to induce vagina mucosal infection, mucosal immunity and inflammations via several mechanisms like the induction of interferon, activation of macrophages and NK cells stimulation.…”

Section: Human Papilloma Virus (Hpv)mentioning

confidence: 99%

Dual and mutual interaction between microbiota and viral infections: a possible treat for COVID-19

et al. 2020

View full text Add to dashboard Cite

All of humans and other mammalian species are colonized by some types of microorganisms such as bacteria, archaea, unicellular eukaryotes like fungi and protozoa, multicellular eukaryotes like helminths, and viruses, which in whole are called microbiota. These microorganisms have multiple different types of interaction with each other. A plethora of evidence suggests that they can regulate immune and digestive systems and also play roles in various diseases, such as mental, cardiovascular, metabolic and some skin diseases. In addition, they take-part in some current health problems like diabetes mellitus, obesity, cancers and infections. Viral infection is one of the most common and problematic health care issues, particularly in recent years that pandemics like SARS and COVID-19 caused a lot of financial and physical damage to the world. There are plenty of articles investigating the interaction between microbiota and infectious diseases. We focused on stimulatory to suppressive effects of microbiota on viral infections, hoping to find a solution to overcome this current pandemic. Then we reviewed mechanistically the effects of both microbiota and probiotics on most of the viruses. But unlike previous studies which concentrated on intestinal microbiota and infection, our focus is on respiratory system’s microbiota and respiratory viral infection, bearing in mind that respiratory system is a proper entry site and residence for viruses, and whereby infection, can lead to asymptomatic, mild, self-limiting, severe or even fatal infection. Finally, we overgeneralize the effects of microbiota on COVID-19 infection. In addition, we reviewed the articles about effects of the microbiota on coronaviruses and suggest some new therapeutic measures.

show abstract

“…Although there are some serious drawbacks like immune response stimulation and introducing undesirable genetic mutations, due to high efficacy, viral vectors are the most common systems for not only in vivo but also in vitro plasmid delivery to mammalian cells. Various virus‐based delivery systems including retrovirus, herpes simplex virus (HSV), adenovirus, adeno‐associated virus (AAV), and lentivirus have been used for in vivo gene therapy in ND [88, 89].…”

Section: Viral‐based Deliverymentioning

confidence: 99%

Overcoming the blood–brain barrier in neurodegenerative disorders and brain tumours

Ebrahimi

Talaei

Aghamiri

et al. 2020

IET nanobiotechnol.

Self Cite

View full text Add to dashboard Cite

Drug delivery is one of the major challenges in the treatment of central nervous system disorders. The brain needs to be protected from harmful agents, which are done by the capillary network, the so-called blood-brain barrier (BBB). This protective guard also prevents the delivery of therapeutic agents to the brain and limits the effectiveness of treatment. For this reason, various strategies have been explored by scientists for overcoming the BBB from disruption of the BBB to targeted delivery of nanoparticles (NPs) and cells and immunotherapy. In this review, different promising brain drug delivery strategies including disruption of tight junctions in the BBB, enhanced transcellular transport by peptide-based delivery, local delivery strategies, NP delivery, and cell-based delivery have been fully discussed.

show abstract

Delivery of genome editing tools: A promising strategy for HPV-related cervical malignancy therapy

Cited by 26 publications

References 137 publications

Immunotherapy and Gene Therapy for Oncoviruses Infections: A Review

Immunotherapy and Gene Therapy for Oncoviruses Infections: A Review

Dual and mutual interaction between microbiota and viral infections: a possible treat for COVID-19

Overcoming the blood–brain barrier in neurodegenerative disorders and brain tumours

Contact Info

Product

Resources

About