Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse

Choi, Mi Ran; Bardhan, Rizia; Stanton-Maxey, Katie J.; Badve, Sunil; Nakshatri, Harikrishna; Stantz, Keith M.; Cao, Ning; Halas, Naomi J.; Clare, Susan E.

doi:10.1007/s12645-012-0029-9

Cited by 138 publications

(125 citation statements)

References 44 publications

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“…38 In recent years, it has been shown that leukocytes are effective in carrying drugs and nanoparticles for cancer therapy, 39,40 while leukocyte cell membrane-camouflaged nanoparticles preserve the surface properties of parent leukocytes and provide a platform for biomimetic delivery. 22,[41][42][43] ICAM-1 is a ligand for LFA-1, which is found on vascular endothelium, squamous cell …”

Section: Discussionmentioning

confidence: 99%

Human cytotoxic T-lymphocyte membrane-camouflaged nanoparticles combined with low-dose irradiation: a new approach to enhance drug targeting in gastric cancer

Zhang

Chen

et al. 2017

IJN

102

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Section: Discussionmentioning

confidence: 99%

Human cytotoxic T-lymphocyte membrane-camouflaged nanoparticles combined with low-dose irradiation: a new approach to enhance drug targeting in gastric cancer

Zhang

Chen

et al. 2017

IJN

102

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“…Near-IR light-induced intracellular release was performed in MDA-MB-231 and SKBR3 (overexpresses HER2) breast cancer cells and compared with release in noncancerous RAW 264.7 macrophage cells. Macrophages were used as the control cells, as they have been shown to be able to phagocytose nanoparticles and deliver them to metastatic tumors where photothermal therapy can be applied (34,35). Future studies would involve macrophages delivering these particles for targeted in vivo drug release.…”

mentioning

confidence: 99%

Near-infrared remotely triggered drug-release strategies for cancer treatment

Goodman

Neumann

Nørregaard

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Remotely controlled, localized drug delivery is highly desirable for potentially minimizing the systemic toxicity induced by the administration of typically hydrophobic chemotherapy drugs by conventional means. Nanoparticle-based drug delivery systems provide a highly promising approach for localized drug delivery, and are an emerging field of interest in cancer treatment. Here, we demonstrate near-IR light-triggered release of two drug molecules from both DNA-based and protein-based hosts that have been conjugated to near-infrared-absorbing Au nanoshells (SiO 2 core, Au shell), each forming a light-responsive drug delivery complex. We show that, depending upon the drug molecule, the type of host molecule, and the laser illumination method (continuous wave or pulsed laser), in vitro light-triggered release can be achieved with both types of nanoparticle-based complexes. Two breast cancer drugs, docetaxel and HER2-targeted lapatinib, were delivered to MDA-MB-231 and SKBR3 (overexpressing HER2) breast cancer cells and compared with release in noncancerous RAW 264.7 macrophage cells. Continuous wave laser-induced release of docetaxel from a nanoshell-based DNA host complex showed increased cell death, which also coincided with nonspecific cell death from photothermal heating. Using a femtosecond pulsed laser, lapatinib release from a nanoshell-based human serum albumin protein host complex resulted in increased cancerous cell death while noncancerous control cells were unaffected. Both methods provide spatially and temporally localized drug-release strategies that can facilitate high local concentrations of chemotherapy drugs deliverable at a specific treatment site over a specific time window, with the potential for greatly minimized side effects. chemotherapy | cancer | drug release | near-infrared | nanoparticle

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“…It has also been widely demonstrated that leukocytes were able to efficiently phagocytize NPs by endocytosis (Choi et al, 2012) (Figure 4C), highlighting their advantages over other cells as drug carriers. The ''Cell-NPs'' drug delivery system can be achieved by simply incubation.…”

Section: Internalizationmentioning

confidence: 74%

A novel strategy to achieve effective drug delivery: exploit cells as carrier combined with nanoparticles

et al. 2017

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Cell-mediated drug delivery systems employ specific cells as drug vehicles to deliver drugs to targeted sites. Therapeutics or imaging agents are loaded into these cells and then released in diseased sites. These specific cells mainly include red blood cells, leukocytes, stem cells and so on. The cell acts as a Trojan horse to transfer the drug from circulating blood to the diseased tissue. In such a system, these cells keep their original properties, which allow them to mimic the migration behavior of specific cells to carry drug to the targeted site after in vivo administration. This strategy elegantly combines the advantages of both carriers, i.e. the adjustability of nanoparticles (NPs) and the natural functions of active cells, which therefore provides a new perspective to challenge current obstacles in drug delivery. This review will describe a fundamental understanding of these cell-based drug delivery systems, and discuss the great potential of combinational application of cell carrier and NPs.

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Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse

Cited by 138 publications

References 44 publications

Human cytotoxic T-lymphocyte membrane-camouflaged nanoparticles combined with low-dose irradiation: a new approach to enhance drug targeting in gastric cancer

Human cytotoxic T-lymphocyte membrane-camouflaged nanoparticles combined with low-dose irradiation: a new approach to enhance drug targeting in gastric cancer

Near-infrared remotely triggered drug-release strategies for cancer treatment

A novel strategy to achieve effective drug delivery: exploit cells as carrier combined with nanoparticles

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