2017
DOI: 10.1073/pnas.1713137114
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Near-infrared remotely triggered drug-release strategies for cancer treatment

Abstract: Remotely controlled, localized drug delivery is highly desirable for potentially minimizing the systemic toxicity induced by the administration of typically hydrophobic chemotherapy drugs by conventional means. Nanoparticle-based drug delivery systems provide a highly promising approach for localized drug delivery, and are an emerging field of interest in cancer treatment. Here, we demonstrate near-IR light-triggered release of two drug molecules from both DNA-based and protein-based hosts that have been conju… Show more

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Cited by 70 publications
(48 citation statements)
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“…5(c)). This light-to-heat conversion has been applied to NIR-triggered controlled release of drugs from gold nanomaterials 52,53 . A synergistic anticancer effect from heat-triggered release of an anticancer drug and tumor ablation has been reported when drug-loaded gold nanorods were used for cancer therapy 52 .…”
Section: Drug Binding Assessment and Nir-triggered Drug Release An Amentioning
confidence: 99%
See 1 more Smart Citation
“…5(c)). This light-to-heat conversion has been applied to NIR-triggered controlled release of drugs from gold nanomaterials 52,53 . A synergistic anticancer effect from heat-triggered release of an anticancer drug and tumor ablation has been reported when drug-loaded gold nanorods were used for cancer therapy 52 .…”
Section: Drug Binding Assessment and Nir-triggered Drug Release An Amentioning
confidence: 99%
“…In contrast, the www.nature.com/scientificreports www.nature.com/scientificreports/ heat transfer from gold nanomaterials to surrounding environment is a great concern for heat sensitive organs including the brain. By using a pulsed laser such as femtosecond laser, drug release resulting from the cleavage of the Au-S bond between gold nanomaterials and nucleic acids was achieved without heating the surrounding environment 53 . The light-to-heat conversion property of MNP@Au nanostars is a promising characteristic that can be used for NIR-triggered controlled release of different types of drugs by cleaving the bonding between the nanostars and the drug at the targeted location in body.…”
Section: Drug Binding Assessment and Nir-triggered Drug Release An Amentioning
confidence: 99%
“…These nanoparticles of Au core-silica layer-Au shell contain internal gadolinium ions for T1 imaging contrast, encapsulated within the silica layer between an inner core and outer Au layer, in a multilayered geometry [77]. The absorbing NIR is used to trigger the release, localized in space and time, of drugs conjugated to nanoshells in order to treat cancer cells while minimizing the toxicity of normal cells [78]. Nanorods have been activated with NIR to generate photothermal therapy to treat metastases, they have the ability to inhibit the migration of cancer cells by targeting the cytoskeletons and integrins [79].…”
Section: Gold Nanoparticlesmentioning
confidence: 99%
“…In the biotechnology field, gold nanoparticles (AuNPs) have been used for a number of applications ranging from drug release [ 13,14 ] and photothermal therapy [ 15,16 ] to biosensing. [ 17,18 ] In principle, encapsulating nanoparticles in polymers can be employed to enhance nanoparticle stability, provide sustained release, enhance their bioavailability, or improve other aspects related to their delivery and storage.…”
Section: Figurementioning
confidence: 99%