2022
DOI: 10.3390/pharmaceutics14040810
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Delivery Systems of Plasmid DNA and Messenger RNA for Advanced Therapies

Abstract: The vast potential of non-viral delivery systems of messenger RNA (mRNA) and plasmid DNA (pDNA) has been demonstrated in the vaccines against coronavirus disease 2019 (COVID-19) [...]

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Cited by 4 publications
(5 citation statements)
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“…Additionally, pDNA is destabilized in vivo because it degrades rapidly. [ 145 ] Current in vivo transfection mainly relies on viral vectors and cationic liposomes. Although these methods are efficient, there are unfavorable risk factors such as cytotoxicity and immunogenicity.…”
Section: Application Of Homs‐based Ddssmentioning
confidence: 99%
“…Additionally, pDNA is destabilized in vivo because it degrades rapidly. [ 145 ] Current in vivo transfection mainly relies on viral vectors and cationic liposomes. Although these methods are efficient, there are unfavorable risk factors such as cytotoxicity and immunogenicity.…”
Section: Application Of Homs‐based Ddssmentioning
confidence: 99%
“…Compared with gene delivery systems, delivering the cytokine protein offers a more straightforward approach. While the gene delivery systems need to send the payloads into specific subcellular positions to conduct the biological functions (Table 2), [ 128 ] the cytokine proteins just require extracellular interactions with the receptors on cell membrane, which pose fewer biological barriers during the delivery process. Moreover, the delivered DNA or mRNA need undergo several molecular biological processes to produce the cytokines, thus, the final expression level and kinetics of the cytokine protein may be highly unpredictable.…”
Section: Protein Delivery Systemsmentioning
confidence: 99%
“…In recent decades, research aimed at developing new effective means of targeted delivery of biologically active substances, including vaccine genes and DNA, to target cells and organs is being carried out [ 1 , 2 , 3 , 4 , 5 , 6 ]. DNA vaccine technologies are extremely relevant for the design of safe and effective vaccines against the emergence of infectious diseases and pathogens also they present a promising alternative vaccine platform that has the potential to treat many diseases, such as cancers, atherosclerosis, and diabetes [ 7 , 8 , 9 ].…”
Section: Introductionmentioning
confidence: 99%
“…DNA vaccine technologies are extremely relevant for the design of safe and effective vaccines against the emergence of infectious diseases and pathogens also they present a promising alternative vaccine platform that has the potential to treat many diseases, such as cancers, atherosclerosis, and diabetes [ 7 , 8 , 9 ]. The necessary plasmid constructs could be quickly produced without any protein purification, as the antigens encoded by DNA vaccines are expressed in vivo [ 5 , 10 ].…”
Section: Introductionmentioning
confidence: 99%