Delphinidin induces antiproliferation and apoptosis of endometrial cells by regulating cytosolic calcium levels and mitochondrial membrane potential depolarization

Lim, Whasun; Song, Gwonhwa

doi:10.1002/jcb.27784

Cited by 6 publications

(6 citation statements)

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“…Using the same model and cells, the same group showed that delphinidin exerts proapoptotic and antiproliferative effects mediated by MAPK and PI3K/AKT signaling proteins. These effects were accompanied by a decrease in the phosphorylation of ERK1/2, AKT, p70S6K, S6 and an increase in the phosphorylation of p38 MAPK and p90RSK [114]. Delphinidin induced apoptosis in human endometrial cells by decreasing the mitochondrial membrane potential and increasing the [Ca 2+ ] i. Safrole-mediated apoptotic cell death in HSC-3 cells was associated with an increase of cytosolic Ca 2+ levels, a decrease in the mitochondrial membrane potential, and activation of Fas-dependent pathways [115].…”

Section: Targeting Calcium Signaling For Anti-cancer Therapymentioning

confidence: 99%

Anti-Cancer Agents in Proliferation and Cell Death: The Calcium Connection

Varghese

Samuel

Sadiq

et al. 2019

IJMS

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Calcium (Ca2+) signaling and the modulation of intracellular calcium ([Ca2+]i) levels play critical roles in several key processes that regulate cellular survival, growth, differentiation, metabolism, and death in normal cells. On the other hand, aberrant Ca2+-signaling and loss of [Ca2+]i homeostasis contributes to tumor initiation proliferation, angiogenesis, and other key processes that support tumor progression in several different cancers. Currently, chemically and functionally distinct drugs are used as chemotherapeutic agents in the treatment and management of cancer among which certain anti-cancer drugs reportedly suppress pro-survival signals and activate pro-apoptotic signaling through modulation of Ca2+-signaling-dependent mechanisms. Most importantly, the modulation of [Ca2+]i levels via the endoplasmic reticulum-mitochondrial axis and corresponding action of channels and pumps within the plasma membrane play an important role in the survival and death of cancer cells. The endoplasmic reticulum-mitochondrial axis is of prime importance when considering Ca2+-signaling-dependent anti-cancer drug targets. This review discusses how calcium signaling is targeted by anti-cancer drugs and highlights the role of calcium signaling in epigenetic modification and the Warburg effect in tumorigenesis.

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Section: Targeting Calcium Signaling For Anti-cancer Therapymentioning

confidence: 99%

Anti-Cancer Agents in Proliferation and Cell Death: The Calcium Connection

Varghese

Samuel

Sadiq

et al. 2019

IJMS

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“…Finally, naringenin significantly increased apoptosis through generation of ER stress regulatory genes, in particular G1 arrest and DNA damage 153 (GADD153), inositol-requiring protein 1α (IRE1α) and GRP78, and through activation of MAPK signaling and inactivation of PI3K pathway. It is interesting to note that the same group of authors investigated these same biological mechanisms highlighted for chirisin, narigenin for other substances, such as apigenin, delphinidin, luteolin, quercetin, silibinin and myricetin in VK2/E6E7 and End1/E6E7 endometriotic cells lines [ 50 , 55 , 61 , 67 , 68 , 69 ]. All these studies are summarized in Table 1 .…”

Section: Resultsmentioning

confidence: 98%

“…A total of 286 studies were initially identified by the search criteria. After applying the selection criteria, a total of 60 trials were included in the systematic review [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 ,…”

Section: Resultsmentioning

confidence: 99%

“…Various mechanisms have been proposed to explain this in vitro action including the alteration of cell cycle proteins, the activation/inactivation of regulatory pathways, modification of ROS levels. Two considerations should be done in relation to the in vitro results obtained: 1. among the 22 published studies, nine were written by the same Chinese group [ 50 , 55 , 61 , 66 , 67 , 68 , 69 , 75 , 76 ]. Therefore, confirmatory findings by independent groups need to be obtained.…”

Section: Discussionmentioning

confidence: 99%

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Endometriosis and Phytoestrogens: Friends or Foes? A Systematic Review

et al. 2021

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The aim of this systematic review was to provide comprehensive and available data on the possible role of phytoestrogens (PE) for the treatment of endometriosis. We conducted an advanced, systematic search of online medical databases PubMed and Medline. Only full-length manuscripts written in English up to September 2020 were considered. A total of 60 studies were included in the systematic review. According to in vitro findings, 19 out of 22 studies reported the ability of PE in inducing anti-proliferative, anti-inflammatory and proapoptotic effects on cultured cells. Various mechanisms have been proposed to explain this in vitro action including the alteration of cell cycle proteins, the activation/inactivation of regulatory pathways, and modification of radical oxidative species levels. Thirty-eight articles on the effects of phytoestrogens on the development of endometriotic lesions in in vivo experimental animal models of endometriosis have been included. In line with in vitro findings, results also derived from animal models of endometriosis generally supported a beneficial effect of the compounds in reducing lesion growth and development. Finally, only seven studies investigated the effects of phytoestrogens intake on endometriosis in humans. The huge amount of in vitro and in vivo animal findings did not correspond to a consistent literature in the women affected. Therefore, whether the experimental findings can be translated in women is currently unknown.

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“…This might be associated with decreased mitochondrial membrane potentials and enhanced cytosolic calcium levels in VK2/E6E7 and End1/E6E7 cells. In addition, Del attenuates the phosphorylation of ERK1/2, AKT, P70S6K, and S6 and enhances the phosphorylation of p38 MAPK and P90RSK . Del treatment has been reported to effectively suppress mechanical unloading-induced muscle weight loss.…”

Section: Additional Discussionmentioning

confidence: 99%

The Multifunctional Benefits of Naturally Occurring Delphinidin and Its Glycosides

Chen

Zhang

Shi

et al. 2019

J. Agric. Food Chem.

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Delphinidin (Del) and its glycosides are water-soluble pigments, belonging to a subgroup of flavonoids. They are health-promoting candidates for pharmaceutical and nutraceutical uses, as indicated by exhibiting antioxidation, anti-inflammation, antimicroorganism, antidiabetes, antiobesity, cardiovascular protection, neuroprotection, and anticancer properties. Glycosylation modification of Del is associated with increased stability and reduced biological activity. Del and its glycosides can be the alternative inhibitors of CBRs, ERα/β, EGFR, BCRP, and SGLT-1, and virtual docking indicates that the sugar moiety may not effectively interact with the active sites of the targets. Structure-based characteristics confer the multifunctional properties of Del and its glycosides. Because of their health-promoting effects, Del and its glycosides are promising and have been developed as potential pharmaceuticals. However, more investigation on the underlying mechanisms of Del and its glycosides in mediating cellular processes with high specificity are still needed. The research progression of Del and its glycosides over the last 10 years is comprehensively reviewed in this article.

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Delphinidin induces antiproliferation and apoptosis of endometrial cells by regulating cytosolic calcium levels and mitochondrial membrane potential depolarization

Cited by 6 publications

References 50 publications

Anti-Cancer Agents in Proliferation and Cell Death: The Calcium Connection

Anti-Cancer Agents in Proliferation and Cell Death: The Calcium Connection

Endometriosis and Phytoestrogens: Friends or Foes? A Systematic Review

The Multifunctional Benefits of Naturally Occurring Delphinidin and Its Glycosides

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