The Multifunctional Benefits of Naturally Occurring Delphinidin and Its Glycosides

Chen, Zhixi; Zhang, Rui; Shi, Weimei; Li, Linfu; Liu, Hai; Liu, Zhiping; Wu, Longhuo

doi:10.1021/acs.jafc.9b05079

Cited by 47 publications

(28 citation statements)

References 182 publications

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“…These forms can also offer an extra advantage of controlling the release of the substance. More studies must decide the appropriate consumption and the most effective type as antidiabetic [ 99 , 102 , 103 , 106 ].…”

Section: Resultsmentioning

confidence: 99%

Plants Secondary Metabolites as Blood Glucose-Lowering Molecules

2021

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Recently, significant advances in modern medicine and therapeutic agents have been achieved. However, the search for effective antidiabetic drugs is continuous and challenging. Over the past decades, there has been an increasing body of literature related to the effects of secondary metabolites from botanical sources on diabetes. Plants-derived metabolites including alkaloids, phenols, anthocyanins, flavonoids, stilbenoids, saponins, tannins, polysaccharides, coumarins, and terpenes can target cellular and molecular mechanisms involved in carbohydrate metabolism. In addition, they can grant protection to pancreatic beta cells from damage, repairing abnormal insulin signaling, minimizing oxidative stress and inflammation, activating AMP-activated protein kinase (AMPK), and inhibiting carbohydrate digestion and absorption. Studies have highlighted many bioactive naturally occurring plants’ secondary metabolites as candidates against diabetes. This review summarizes the current knowledge compiled from the latest studies published during the past decade on the mechanism-based action of plants-derived secondary metabolites that can target various metabolic pathways in humans against diabetes. It is worth mentioning that the compiled data in this review will provide a guide for researchers in the field, to develop candidates into environment-friendly effective, yet safe antidiabetics.

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Section: Resultsmentioning

confidence: 99%

Plants Secondary Metabolites as Blood Glucose-Lowering Molecules

2021

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“…It has been reported that the physiological activities of quercetin include anticancer, hypoglycemic, and antiobesity activities [42,43,48]. Delphinidin has a variety of pharmacological activities, including anticancer, cardiovascular protection, neuroprotection, antidiabetes, and antiobesity activities [49]. Ferulic acid could offer beneficial effects, such as anticancer, antidiabetes, and antineurodegenerative effects [50].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Bioactive Components in the Fruit, Roots, and Leaves of Alpinia oxyphylla by UPLC-MS/MS

Wang

2021

Evidence-Based Complementary and Alternative Medicine

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Alpinia oxyphylla (A. oxyphylla) fruit has long been used in traditional Chinese medicine. In our study, the bioactive components of its roots, fruit, and leaves were investigated, and their potential medical value was predicted. The root, fruit, and leaf samples were analyzed using a UPLC-MS/MS system. The mass spectrometry outcomes were annotated by MULTIAQUANT. The “compound-disease targets” were used to construct a pharmacology network. A total of 293, 277, and 251 components were identified in the roots, fruit, and leaves, respectively. The fruit of A. oxyphylla had a higher abundance of flavonols. The roots of A. oxyphylla were enriched in flavonols and phenolic acids. The leaves of A. oxyphylla exhibited high contents of flavonols, phenolic acids, and tannins. Furthermore, network pharmacology analysis showed that flavonoids are the most important effectors in the fruit of A. oxyphylla and phenolic acids are the most important effectors in the roots and leaves. Moreover, the results suggested that the tissues of A. oxyphylla might play a role in the regulation of disease-related genes. The whole plant of A. oxyphylla is rich in natural drug components, and each tissue has high medicinal value. Therefore, comprehensive utilization of A. oxyphylla can greatly improve its economic value.

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“…Treatment of psoriasis with synthetic medicines is restricted because of its practicability, comfort, and extreme unfavorable adverse effects like hepatotoxicity and renal damage. 5), Madecassoside (6), Astilbin (7), Biacalin (8), Berberine (9), Boswellic acid (10), Caffeine (11), Camptothecin (12) & Iso-Camptothecin (13), Cannabinoids (14,15,16,17), Chamazulene (18), Chlorogenic acid (19), Cholchicine (20), Curcumin (21), Delphinidine (22), Embelin (23), Fumeric acid (24), Genistein (25), Glycerhiznic acid (26), Gossypol (27), Hypericin (28), Hyperforin (29), Indirubin (30), Isoliquiritigenin (31), Koumine (32), Luteolin (33), P-anisaldehyde (34), Pcoumaric acid (35), P-resinol (36), Podophyllotoxin (37), Polyandric acid A (38), Polyandric acid B (39), Psoralen (40), Quercitin (41), Resveratrol (42), , Syllimarin (43), 4-methylthiobutylisothiocyanate (44).…”

Section: Discussionmentioning

confidence: 99%

A review on the important phytochemicals and their role in psoriasis

Pandey

Shukla

Dubey

et al. 2021

JANS

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Psoriasis may emerge at any stage of life irrespective of age, sex or geographic location. It is identified as a chronic immune-linked inflammatory skin disease that affects all human races. Psoriasis is often more Caucasian than non-Caucasian groups of human races and in geographic areas, like higher latitudes and Western countries. Therefore, attention should be paid to both genetic and environmental causes of psoriasis. Natural products have significantly contributed and encouraged the advances in skin disease treatment like psoriasis. The maximum number of phytochemicals is now being used worldwide, including various plants, herbs, and formulations. In addition, some phytochemicals like psoralen, aloe-emodin, curcumin etc. have also been isolated in pure form and have also shown their efficacy in the management of psoriasis. The presence of such phytochemicals confirms the effectiveness of few herbal therapies. This paper reviews some of the promising phytochemicals and their potential molecular target sites and mechanism of action, which may aid in designing and producing more precise and selective antipsoriatic agents. Exploring and recognizing phytochemicals as to how they function will facilitate more site-specific delivery methods for psoriasis care.

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The Multifunctional Benefits of Naturally Occurring Delphinidin and Its Glycosides

Cited by 47 publications

References 182 publications

Plants Secondary Metabolites as Blood Glucose-Lowering Molecules

Plants Secondary Metabolites as Blood Glucose-Lowering Molecules

Analysis of Bioactive Components in the Fruit, Roots, and Leaves of Alpinia oxyphylla by UPLC-MS/MS

A review on the important phytochemicals and their role in psoriasis

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