Plants Secondary Metabolites as Blood Glucose-Lowering Molecules

Shehadeh, Mayadah B.; Suaifan, Ghadeer A. R. Y.; Abu-Odeh, Ala' M

doi:10.3390/molecules26144333

Cited by 60 publications

(35 citation statements)

References 210 publications

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“…α-Glucosidase inhibitors are capable of inhibiting the conversion of carbohydrates into small-intestine-absorbable monosaccharides, and therefore they have the potential for the treatment of diabetes mellitus type 2 (DM2) by controlling blood sugar levels [ 38 , 39 ]. In this study, compounds 1–10 were then further tested for their in vitro α -glucosidase inhibitory activity, with acarbose employed as a reference compound.…”

Section: Resultsmentioning

confidence: 99%

Polycyclic Phenol Derivatives from the Leaves of Spermacoce latifolia and Their Antibacterial and α-Glucosidase Inhibitory Activity

Liu

Zeng

et al. 2022

Molecules

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Three new polycyclic phenol derivatives, 2-acetyl-4-hydroxy-6H-furo [2,3-g]chromen-6-one (1), 2-(1′,2′-dihydroxypropan-2′-yl)-4-hydroxy-6H-furo [2,3-g][1]benzopyran-6-one (2) and 3,8,10-trihydroxy-4,9-dimethoxy-6H-benzo[c]chromen-6-one (8), along with seven known ones (3–7, 9 and 10) were isolated for the first time from the leaves of Spermacoce latifolia. Their structures were determined by spectroscopic analysis and comparison with literature-reported data. These compounds were tested for their in vitro antibacterial activity against four Gram-(+) bacteria: Staphyloccocus aureus (SA), methicillin-resistant Staphylococcus aureus (MRSA), Bacillus cereus (BC), Bacillus subtilis (BS), and the Gram-(−) bacterium Escherichia coli. Compounds 1, 2, 5 and 8 showed antibacterial activity toward SA, BC and BS with MIC values ranging from 7.8 to 62.5 µg/mL, but they were inactive to MRSA. Compound 4 not only showed the best antibacterial activity against SA, BC and BS, but it further displayed significant antibacterial activity against MRSA (MIC 1.95 µg/mL) even stronger than vancomycin (MIC 3.9 µg/mL). No compounds showed inhibitory activity toward E. coli. Further bioassay indicated that compounds 1, 4, 5, 6, 8 and 9 showed in vitro α-glucosidase inhibitory activity, among which compound 9 displayed the best α-glucosidase inhibitory activity with IC50 value (0.026 mM) about 15-fold stronger than the reference compound acarbose (IC50 0.408 mM). These results suggested that compounds 4, 8 and 9 were potentially highly valuable compounds worthy of consideration to be further developed as an effective anti-MRSA agent or effective α-glucosidase inhibitors, respectively. In addition, the obtained data also supported that S. latifolia was rich in structurally diverse bioactive compounds worthy of further investigation, at least in searching for potential antibiotics and α-glucosidase inhibitors.

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Section: Resultsmentioning

confidence: 99%

Polycyclic Phenol Derivatives from the Leaves of Spermacoce latifolia and Their Antibacterial and α-Glucosidase Inhibitory Activity

Liu

Zeng

et al. 2022

Molecules

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“…Some clinically important secondary metabolites are used as antiobesity agents [ 129 ]. Several phytochemicals are employed to reduce the process of adipogenesis, carbohydrates absorption in the small intestine, collection of hepatic triglycerides, deposition of adipose tissue, weight loss, and enhances the antiobesity potential, activity of PPAR- α and PAR γ -responsive genes ( Table 3 ) [ 130 , 131 ]. Flavonoids have the potential to inhibit lipase activity and control adipogenesis, such as quercetin, catechins, resveratrol, and galangin.…”

Section: Therapeutic Application Of Phytochemicals In Obesitymentioning

confidence: 99%

Biogenic Phytochemicals Modulating Obesity: From Molecular Mechanism to Preventive and Therapeutic Approaches

Kumar

Singh

Lakhawat

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The incidence of obesity and over bodyweight is emerging as a major health concern. Obesity is a complex metabolic disease with multiple pathophysiological clinical conditions as comorbidities are associated with obesity such as diabetes, hypertension, cardiovascular disorders, sleep apnea, osteoarthritis, some cancers, and inflammation-based clinical conditions. In obese individuals, adipocyte cells increased the expression of leptin, angiotensin, adipocytokines, plasminogen activators, and C-reactive protein. Currently, options for treatment and lifestyle behaviors interventions are limited, and keeping a healthy lifestyle is challenging. Various types of phytochemicals have been investigated for antiobesity potential. Here, we discuss pathophysiology and signaling pathways in obesity, epigenetic regulations, regulatory mechanism, functional ingredients in natural antiobesity products, and therapeutic application of phytochemicals in obesity.

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“…Alkaloid memiliki efek penghambatan enzim α-glukosidase dan αglukosidase yang menyebabkan penundaan penyerapan glukosa di usus dan mencegah peningkatan glukosa darah. Senyawa yang mengandung nitrogen ini juga dapat menghambat dipeptidil peptidase-4 (DPP-4) (Shehadeh et al, 2021). Tang et al (2017), menyebutkan bahwa alkaloid dapat mencegah hiperglikemia dengan meningkatkan konsumsi glukosa dan sintesis glikogen melalui peningkatan aktivitas heksokinase pada sel.…”

Section: Hasil Dan Pembahasanunclassified

Penurunan Kadar Glukosa Darah Mencit (Mus Musculus) yang Diinduksi Hiperglikemia oleh Ekstrak Etanol Daun Sirsak (Annona muricata L.)

et al. 2022

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Hyperglycemia is one of the diabetes mellitus characteristics. Soursop leaves (Annona muricata L.) has been used traditionally to reduce blood glucose level and clinically need to be proven. The aim of this study was to observe the effect of ethanol extract of soursop leaves (EDS) on blood glucose levels of hyperglycemia mice (Mus musculus). This was an experimental study with a pre-post test control group design. Thirty mice was used as animal models and was hyperglycemia induced by alloxan 150mg/kg b.w, respectively. Treatment EDS has been given for 14 days with the variation of doses; 200 mg/Kg b.w, 300 mg/Kg b.w, and 400 mg/Kg bw. Fasting blood glucose level was measured before and after EDS treatment by glucocheck. Data were analyzed by ANOVA and Duncan for further tests to evaluate the effect of EDS while the difference in blood glucose levels in pre-post treament was analyzed by paired t-test. The result showed that EDS significantly reduced blood glucose levels (p < 0.05). EDS with 400 mg/Kg bw dose showed the strongest effect in reducing glucose levels, followed by 300 mg/Kg b.w and 200 mg/Kg b.w doses. In conclusion, EDS has the potential to develop as an agent to reduce blood glucose in diabetes mellitus.

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Plants Secondary Metabolites as Blood Glucose-Lowering Molecules

Cited by 60 publications

References 210 publications

Polycyclic Phenol Derivatives from the Leaves of Spermacoce latifolia and Their Antibacterial and α-Glucosidase Inhibitory Activity

Polycyclic Phenol Derivatives from the Leaves of Spermacoce latifolia and Their Antibacterial and α-Glucosidase Inhibitory Activity

Biogenic Phytochemicals Modulating Obesity: From Molecular Mechanism to Preventive and Therapeutic Approaches

Penurunan Kadar Glukosa Darah Mencit (Mus Musculus) yang Diinduksi Hiperglikemia oleh Ekstrak Etanol Daun Sirsak (Annona muricata L.)

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