Delta-Aminolevulinic Acid Dehydratase Activity of Erythrocytes and Liver Tissue in Man

δ-Aminolevulinic acid dehydratase single nucleotide polymorphism 2 (ALAD2) and peptide transporter 2*2 haplotype (hPEPT2*2) differently influence neurobehavior in low-level lead exposed children

“…The percentages of genetic variants observed in this sample closely approximated reported frequencies from previous mixed race studies (Benkman et al, 1983; Petrucci et al, 1982; Secchi et al, 1974). Consistent with reported rates, only one child (female) was homozygous for ALAD 2 and this child’s data were included with ALAD 2 heterozygous females for subsequent analyses.…”

Genetic Susceptibility to Lead Poisoning

“…The inhibition of erythrocyte ALAD activity is a sensitive indicator of exposure to lead and has been used as a diagnostic tool (28)(29)(30). The series of reactions leading to heme synthesis begins with succinyl coenzyme A (CoA) and glycine and ends with the insertion of an Fe2+ into a molecule of protoporphyrin.…”

Characterizing Golden Eagle Risk to Lead and Anticoagulant Rodenticide Exposure: A Review

“…Studies of lead workers have shown that ALAD activity correlated inversely with PbB (Alessio et al 1976;Gurer-Orhan et al 2004;Meredith et al 1978;Schuhmacher et al 1997;Tola et al 1973;Wada et al 1973), as has been seen in subjects with no occupational exposure (Secchi et al 1974). Erythrocyte ALAD and hepatic ALAD activities were correlated directly with each other and correlated inversely with PbBs in the range of 12-56 μg/dL (Secchi et al 1974).…”

“…Erythrocyte ALAD and hepatic ALAD activities were correlated directly with each other and correlated inversely with PbBs in the range of 12-56 μg/dL (Secchi et al 1974). …”