Deltamethrin-induced oxidative damage and biochemical alterations in rat and its attenuation by Vitamin E

Yousef, Mokhtar I.; Awad, T.I.; Mohamed, Edriss H.

doi:10.1016/j.tox.2006.08.008

Cited by 236 publications

(136 citation statements)

References 36 publications

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“…Kidney is one of the target organ of experimental animals attacked by organophosphorous compounds. So urea, uric acid and creatinine plasma levels are kidney function parameters as altered by pesticides (Mansour and Mossa, 2010;Yhe et al, 2008;Yousef et al, 2006). In this study, malathion exposure group has a significant increased in the serum urea, uric acid and creatinine levels compared to control one this result agree with (Ahlam, 2009) by dosing rats with organophosphrous pesticide (profenofos) 1/20 LD50.…”

Section: Discussionsupporting

confidence: 88%

“…In this study, malathion exposure group has a significant increased in the serum urea, uric acid and creatinine levels compared to control one this result agree with (Ahlam, 2009) by dosing rats with organophosphrous pesticide (profenofos) 1/20 LD50. This elevation may be due to kidneys damage caused by malathion as kidney is the target organ of OP pesticides (Sivapiriya et al, 2006) and urea is the end product of protein catabolism so Increased blood urea is correlated with an increased protein catabolism in mammalian body and/or referred to kidney dysfunction and caused from increased breakdown of tissue or impaired excretion (Yousef et al, 2006;El-Demerdash, 2004). In this study uric acid increase may be related to either increase in protein degradation, which is involved in uric acid formation, or the toxic effect of malathion on the kidneys (Eraslan et al, 2007), which indicated by present histopathological picture as showed swelling and vacuolization in the lining endothelium of the glomerular tuft associated with degeneration in the lining epithelium of the tubules.…”

Section: Discussionmentioning

confidence: 99%

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Protective Role of Vitamin C and Green Tea Extract on Malathion-Induced Hepatotoxicity and Nephrotoxicity in Rats

Elzoghby¹,

Hamoda²,

Aboubakr³

et al. 2014

American Journal of Pharmacology and Toxicology

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The present study was designed to determine the modulating effect of green tea and vitamin C against adverse effects of malathion. Animals were divided into four groups 5 rats /group). Group one was used as a control. Group two given malathion (50 mg/kg/day; 1/50 of the LD50 for four weeks). Group three and Group four were given malathion (50 mg/kg/day; 1/50 of the LD50 for four weeks) plus vitamin C (200 mg/kg/day) and plus green tea (36 mg/kg/day) respectively. At the end of the fourth week, the malathion-treated group had significantly lower Red Blood Cell count (RBCs), Hemoglobin concentration (Hb), Packed Cell Volume (PCV%) and leucocytes (WBCs) than the control group. Compared to the control group, the malathion-treated group had significantly higher serum Alkaline Phosphatase (ALP), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Lactate Dehydrogenase (LDH), urea, creatinine and uric acid levels than the control group. The malathion treated rats also had significantly lower serum total protein, albumin and globulin levels than the control group, but the malathion plus vitamin C and malathion plus green tea groups did not differ from the control group in terms of these parameters. Moreover, concomitant vitamin C and green tea treatment significantly normalized, at least partially, all of the other hematological and biochemical parameters that were altered by malathion. Liver tissue homogenate in malathion treated group had lower Glutathione (GSH), Glutathione Peroxidase (GSH-PX) and Superoxide Dismutase (SOD) levels accompanied with higher level of Malondialdehyde (MDA) than the control group. Histopathological studies revealed that the malathion-treated, malathion plus vitamin C and malathion plus green tea treated groups exhibited histopathological changes in liver and kidney tissues, although some pathological features were only observed in the malathion-treated group. Thus, vitamin C and green tea can reduce malathion hepatotoxicity and nephrptoxicity.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Protective Role of Vitamin C and Green Tea Extract on Malathion-Induced Hepatotoxicity and Nephrotoxicity in Rats

Elzoghby¹,

Hamoda²,

Aboubakr³

et al. 2014

American Journal of Pharmacology and Toxicology

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“…Administration of quercetin resulted in significant increases in serum AST and ALT levels. These may have resulted from leakage of these enzymes into the circulation, and may indicate liver damage and altered liver function (31,32). However, quercetin (100 mg/kg BW) in mice treated with DMBA decreased serum AST and ALT levels, although this difference was not significant.…”

Section: Discussionmentioning

confidence: 98%

Quercetin acts as an antioxidant and downregulates CYP1A1 and CYP1B1 against DMBA-induced oxidative stress in mice

Choi

Kim

2012

Oncol Rep

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Abstract. We investigated the effects of quercetin on 7,12-dimethylbenz(a)anthracene (DMBA)-induced oxidative stress and the expression of CYP1A1 and CYP1B1 in mice. Quercetin was administered orally to mice at 100 or 250 mg/kg BW for 18 days, after which DMBA (34 mg/kg BW) was administered intragastrically twice. Quercetin showed side effects such as increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in DMBA-untreated mice. Also, quercetin induced AST and ALT in DMBA-treated, although this was not significantly different from levels in DMBA-treated controls. The thiobarbituric acid reactive substances (TBARS) value showed a tendency to decrease following quercetin treatment; these decreases were significantly greater in the DMBA-treated compared to the untreated groups. Also, catalase and superoxide dismutase (SOD) activities as well as their mRNA expression were increased by quercetin; this increase was more pronounced in DMBA-treated compared to untreated mice. DMBA induced CYP1 activity as well as expression of CYP1A1 and CYP1B1. Each of these effects was significantly reduced by quercetin; however, this reduction was observed for CYP1A1 at only the higher dose and for CYP1B1 at both doses. These data suggest that quercetin shows antioxidant activity against DMBA-induced oxidative stress. Moreover, its regulation of CYP1A1 and CYP1B1 suggests the potential of quercetin as an anticancer supplement.

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“…Groups of Swiss albino mice of both sexes (8)(9)(10) weeks old) weighing (22 暲 1) g were housed under standard laboratory conditions and had free access to food and water.…”

Section: Sub-acute Toxicitymentioning

confidence: 99%

“…Several studies have shown that, pyrethroid caused alterations in biochemistry, hematology and reproduction [9] . Repeated daily oral doses of pyrethroid insecticide of 毩-cypermethrin at 1/10 LD 50 altered the biochemical parameters, decreased cytochrome P450 content, antioxidant status which correlated with histopathological changes of tissues [10] .…”

Section: Introductionmentioning

confidence: 99%

Toxicological studies for some agricultural waste extracts on mosquito larvae and experimental animals

El-Maghraby

Nawwar

Bakr

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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Deltamethrin-induced oxidative damage and biochemical alterations in rat and its attenuation by Vitamin E

Cited by 236 publications

References 36 publications

Protective Role of Vitamin C and Green Tea Extract on Malathion-Induced Hepatotoxicity and Nephrotoxicity in Rats

Protective Role of Vitamin C and Green Tea Extract on Malathion-Induced Hepatotoxicity and Nephrotoxicity in Rats

Quercetin acts as an antioxidant and downregulates CYP1A1 and CYP1B1 against DMBA-induced oxidative stress in mice

Toxicological studies for some agricultural waste extracts on mosquito larvae and experimental animals

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