Delusions and processing of discrepant information: An event-related brain potential study

Debruille, J. Bruno; Kumar, Namita; Saheb, Dominique; Chintoh, Araba; Gharghi, Daryoush; Lionnet, Claire; King, Suzanne

doi:10.1016/j.schres.2006.07.014

Cited by 35 publications

(47 citation statements)

References 47 publications

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“…While further studies are thus necessary to understand the circumstances under which P1 differences can be found, the absence of a difference observed here is consonant with the notion that the early visual processing of the context words was normal in patients under the conditions of the present experiment. In contrast, visual N1s have been found intact in schizophrenia Doniger et al, 2002;Foxe et al, 2001;Debruille et al, 2007) with only few exceptions (Bruder et al, 1998). Like the absence of P1 differences, the present N1 results suggest that the early visual processing of patients was similar to that of normals.…”

Section: Discussioncontrasting

confidence: 49%

“…P1s have been found to be reduced in schizophrenia patients in several studies (Schechter et al, 2005;Foxe et al, 2005;Doniger et al, 2002a). Nevertheless, an absence of P1 difference has previously been reported in a protocol using faces as stimuli (Johnston et al, 2005) and the results of one study suggested that P1 differences may depend on the severity of symptoms (Connolly et al, 1983;Debruille et al, 2007). While further studies are thus necessary to understand the circumstances under which P1 differences can be found, the absence of a difference observed here is consonant with the notion that the early visual processing of the context words was normal in patients under the conditions of the present experiment.…”

Section: Discussionmentioning

confidence: 96%

“…This creates an important interpretation problem for many studies. In an attempt to focus on the latter type of processing and thus to circumvent the context deficit, we recently implemented a protocol (Debruille et al, 2007) in which context was made as easy to process as possible, so that patients would perform this process as well as normals. This context was the semantic category word 'ANIMAL?'.…”

Section: Context Processing In Schizophreniamentioning

confidence: 99%

“…For bilingual subjects, the English or the French version of the experiment was chosen according to which written language the subject used most frequently in the past five years. The characteristics of the target words used can be found in Debruille et al (2007). When the first stimulus was the question word 'ANIMAL?…”

Section: Taskmentioning

confidence: 99%

See 3 more Smart Citations

Circumventing the deficit of context processing in schizophrenia: An event-related brain potential study

Debruille¹,

Kumar²,

Saheb³

et al. 2010

International Journal of Psychophysiology

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Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 96%

Section: Context Processing In Schizophreniamentioning

confidence: 99%

Section: Taskmentioning

confidence: 99%

See 2 more Smart Citations

Circumventing the deficit of context processing in schizophrenia: An event-related brain potential study

Debruille¹,

Kumar²,

Saheb³

et al. 2010

International Journal of Psychophysiology

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“…On the other hand, given the robustness of the semantic matching effect in version 2, it seems that these links could be studied in individual subjects. This could be of interest for case studies in psychiatry, for instance in the exploration of the neurocognitive mechanisms of delusion (Debruille et al, 2007;Neagoe, 2000;Silva & Leong, 1994).…”

Section: Discussionmentioning

confidence: 99%

Effects of semantic matching and of semantic category on reaction time and N400 that resist numerous repetitions

Debruille¹,

Renoult²

2009

Neuropsychologia

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a b s t r a c tThe N400 event-related potential (ERP) is a brain response to any potentially meaningful stimulus. Like reaction time (RT), the amplitude of this ERP is reduced by the prior presentation of a semantically related stimulus. However, results of a few studies suggest that this semantic matching effect could be reduced when using already presented stimuli, and rapidly disappear with further presentations. On the other hand, the topography of the N400 on the scalp depends on the semantic category of the stimulus. Like the semantic matching effect, this category effect also seems to be smaller for already presented stimuli. Taken together, these facts suggest that the semantic processes indexed by the N400 could be absent for stimuli that have already been presented multiple times. Here, we show that this conclusion would be premature. We used the same semantic categorization task in conditions of massive repetition and in conditions of single presentation. We found that the effects of semantic matching and of semantic category on RTs and N400s were similar in the two conditions. Moreover, the localization of the sources of the independent components accounting for the match effect revealed brain regions that were common to both conditions. These results suggest that N400s and RTs could be used to study the semantic processes triggered by one content word.

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Physiological Correlates of Positive Symptoms in Schizophrenia

Galderisi¹,

Vignapiano²,

Mucci³

et al. 2014

Current Topics in Behavioral Neurosciences

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Patients with schizophrenia have been hypothesized to have a functional impairment in filtering irrelevant sensory information, which may result in positive symptoms such as hallucinations or delusions. Many evidences suggest that abnormalities in the event-related brain potentials (ERPs), resting state electroencephalography (EEG) and synchronized oscillatory activity of neurons may reflect core pathophysiological mechanisms of schizophrenia. Abnormalities in amplitude and latency of the ERPs reflecting aberrations in gating and difficulties in the detection of changes in auditory stimuli, as well as defects in stimuli evaluation and integration of information are common in patients with schizophrenia. This chapter highlights the findings of electrophysiological studies in schizophrenia dealing with early sensory perception and attention, automatic sensory detection of stimuli changes and cognitive evaluation and integration of information, relevant to the pathophysiological mechanisms underpinning hallucinations and delusions. Results of electrophysiological studies investigating the neural correlates of positive symptoms suggest aberrant intrinsic organization of functional brain networks.

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Delusions and processing of discrepant information: An event-related brain potential study

Cited by 35 publications

References 47 publications

Circumventing the deficit of context processing in schizophrenia: An event-related brain potential study

Circumventing the deficit of context processing in schizophrenia: An event-related brain potential study

Effects of semantic matching and of semantic category on reaction time and N400 that resist numerous repetitions

Physiological Correlates of Positive Symptoms in Schizophrenia

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