Demência na doença de Parkinson

Caixeta, Leonardo; Vieira, Renata Teles

doi:10.1590/s1516-44462008000400013

Cited by 10 publications

(7 citation statements)

References 23 publications

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“…Parkinson dementia is characterized by bradykinesia, tremor at rest, gait disturbance, postural problems, rigidity, dysarthria, dysfunction of the judgment, reasoning, memory, depression, anxiety, insomnia, and cognitive decline due to loss of midbrain dopaminergic neurons in the pars compacta of the substantia nigra and consequent loss of dopamine input to the caudate nucleus and putamen (striatum), and is more prevalent in men. Idiopathic Parkinson disease with dementia can show hypoperfusion patterns similar to those observed in AD, but basal ganglia hypoperfusion is far more frequent, as is frontal precentral hypoperfusion [32].…”

Section: Brief Comment About Our Chaptersmentioning

confidence: 89%

Introductory Chapter: Cognitive Disorders and Its Historical Background

Sibat¹,

Valdés²

2019

Cognitive Disorders

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Section: Brief Comment About Our Chaptersmentioning

confidence: 89%

Introductory Chapter: Cognitive Disorders and Its Historical Background

Sibat¹,

Valdés²

2019

Cognitive Disorders

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“…Patients with serious psychiatric disorders, dementia according to current studies 11 , 12 , 17 and those who have had bleeding or convulsion after surgical intervention were excluded.…”

Section: Methodsmentioning

confidence: 99%

“…However, some studies link DBS-STN to memory, verbal fluency, executive functioning and behavioral impairments. 9 , 11 , 13 , 16 , 18 …”

Section: Introductionmentioning

confidence: 99%

Neuropsychological and quality of life assessment in patients with Parkinson's disease submitted to bilateral deep brain stimulation in the subthalamic nucleus

Heluani

Porto

Listik

et al. 2012

Dement. neuropsychol.

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Deep brain stimulation (DBS) has been widely used to control motor symptoms and improve quality of life in patients with Parkinsons disease (PD). Recently, DBS in the subthalamic nucleus (STN) has become the preferred target for patients with mixed motor symptoms. Despite resultant motor and quality of life improvements, the procedure has been associated with cognitive decline, mainly in language skills, and also with psychiatric symptoms.ObjectiveTo evaluate the influence of DBS in the STN on cognition, mood and quality of life.MethodsWe studied 20 patients with PD submitted to DBS in the STN from May 2008 to June 2012 with an extensive battery of cognitive tests including memory, language, praxis, executive functions and attention assessments; the Parkinson's Disease Quality of Life Questionnaire (PDQ-39); and the Hospital Anxiety and Depression Scale (HAD), were applied both before and after the surgery. Data was analyzed using SPSS version 17.0 and results compared using the paired Student's t test.ResultsA total of 20 patients with pre and post-operative assessments were included. A statistically significant improvement was found in total score and on subscales of mobility, activities of daily living and emotional well-being from the PDQ-39 (P=0.009, 0.025, 0.001 and 0.034, respectively). No significant difference was found on the cognitive battery or mood scale.ConclusionDBS in the SNT improved quality of life in PD with no negative impact on cognitive skills and mood.

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“…The disease is also linked to changes in serotonin, noradrenaline, and acetylcholine in brain function,3 and is characterized by three main symptoms: tremor, bradykinesia and rigidity. Postural instability is also very common, and there are other widely shared non-predominant symptoms such as sialorrhea, sweating, increased peripheral vagal tone, blepharospasm, psychiatric and psychotic symptoms, as well as cognitive disorders 45…”

mentioning

confidence: 99%

“…Postural instability is also very common, and there are other widely shared non-predominant symptoms such as sialorrhea, sweating, increased peripheral vagal tone, blepharospasm, psychiatric and psychotic symptoms, as well as cognitive disorders 45…”

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confidence: 99%

Impulsiveness and executive functions in Parkinson’s disease

Almeida

Hamdan

2019

Dement. neuropsychol.

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Cognitive functions, such as impulsiveness and executive functions, are often impaired in Parkinson’s disease. Objective: to analyze the relationship between impulsiveness and executive functions (EF) in people with Parkinson’s disease (PD). Methods: a correlation study involving a sample of 50 patients with an established diagnosis of PD aged 40 years or older was conducted using the following instruments: Demographic Questionnaire, Montreal Cognitive Assessment Basic (MOCA-B), Barratt’s Impulsiveness Scale (BIS-11) and Frontal Assessment Battery (FAB). Results: Pearson’s correlation analysis indicated low associations (p<0.05) between the MOCA-B and BIS-11, with a value of -0.11, and between the FAB and BIS-11, with a value of -0.16. A significant correlation between the MOCA-B and FAB was found, with a value of 0.73. Conclusion: this study revealed an association between EF and other cognitive functions, but no association between impulsivity and EF in Parkinson’s disease.

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Demência na doença de Parkinson

Cited by 10 publications

References 23 publications

Introductory Chapter: Cognitive Disorders and Its Historical Background

Introductory Chapter: Cognitive Disorders and Its Historical Background

Neuropsychological and quality of life assessment in patients with Parkinson's disease submitted to bilateral deep brain stimulation in the subthalamic nucleus

Impulsiveness and executive functions in Parkinson’s disease

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