Publish/subscribe (pub/sub) is a popular communication paradigm in the design of largescale distributed systems. A fundamental challenge in deploying pub/sub systems on a data center or a cloud infrastructure is efficient and cost-effective resource allocation that would allow delivery of notifications to all subscribers. In this paper, we provide answers to the following three fundamental questions: Given a pub/sub workload, (1) what is the minimum amount of resources needed to satisfy all the subscribers, (2) what is a cost-effective way to allocate resources for the given workload, and (3) what is the cost of hosting it on a public Infrastructure-as-a-Service (IaaS) provider like Amazon EC2.To answer these questions, we formulate a problem coined Minimum Cost Subscriber Satisfaction (MCSS). We prove MCSS to be NP-hard and provide an efficient heuristic solution based on a combination of optimizations. We evaluate the solution experimentally using real traces from Spotify and Twitter along with a pricing model from Amazon. We show the impact of each optimization using a naive solution as the baseline. Using a variety of practical scenarios for each dataset, we also show that our solution scales well for millions of subscribers and runs fast.