Demographic and Clinical Characteristics of 63 Children with Myelomeningoceles

Sogoba, Youssouf; Diallo, Seybou Hassane; Amadou, Issa; Sogoba, Boubacar; Diallo, Moussa; Kamaté, Benoi; Mariko, Daouda; Oumar, Coulibaly; Quenum, Kisito; Diall, Hawa; Diakité, Leonie; Diallo, Salimata; Maïga, Belco; Traoré, Fousseyni; Sacko, Karamoko; Diallo, Oumar; Kanikomo, Drissa; Maiga, Youssoufa

doi:10.4236/ojmn.2021.112007

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Multiple factors are involved in the etiology of myelomeningocele including maternal, environmental and genetic elements 18 . Maternal factors include low folate intake 19 , alcohol consumption 20 , usage of anticonvulsants 21 , diabetes 22 andhyperthermia 23 . On the other hand, most of the cases of MMC are sporadic in origin.…”

Section: Introductionmentioning

confidence: 99%

Association of Location of Cyst with the family history and Mutated Gene among patients of Myelomeningocele

Fatima¹,

Gul²,

Ishaq³

et al. 2021

PJMHS

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Aim: To determine association of location of cyst with the family history and mutated gene among patients of myelomeningocele. Methodology: This cross sectional study consists of fifty diagnosed cases of myelomeningocele and ten healthy individuals taken as controls. The cases were collected from Jinnah Postgraduate Medical Center (JPMC) for a period of six months. The research was conducted in Dow Diagnostic and Research Laboratory (DDRL) (DUHS). Majority of the patients included in the study were neonates. Patients were examined for the presence and site of the cyst. Family history of the patients was also recorded. After taken informed consent from the patient’s attendants, blood was drawn by a trained phlebotomist. DNA was extracted from whole blood followed by PCR amplification of VANGL1 gene. Results: We found that among fifty individuals five patients showed mutation in VANGL1 gene. Mutation was absent entirely from the controls. The cyst was mostly (92%) present in the lumbar region. Only 2% patients showed positive family history. The association between site of the cyst and family history was statistically significant. Conclusion: It is concluded that all mutation of VANGL1 gene was present at lumbar region.There was a strong relation between location of cyst and family history. Keywords: Myelomeningocele, cyst, VANGL1 gene, PCR, mutation.

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Section: Introductionmentioning

confidence: 99%

Association of Location of Cyst with the family history and Mutated Gene among patients of Myelomeningocele

Fatima¹,

Gul²,

Ishaq³

et al. 2021

PJMHS

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Myelomeningocele about 100 Cases and Review of Literature

Echnin,

El Khamouye,

Ibahioin

et al. 2024

EJMED

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Spina bifida is a group of vertebro-medullary malformations with a common defect in neural tube closure during embryonic life. Myelomeningocele (MMG) is the most frequent anatomical subtype. The aim of this study is to investigate the epidemiology, diagnosis and treatment of MMG. It is a retrospective study based on a series of 100 cases of MMG recorded over 10 years in the neurosurgery department of Chu Ibn Rochd, Casablanca, between 2009 and 2019. The frequency of occurrence is an average of 10 cases per year; consanguinity is found in 24% of cases, the most predominant location was lumbar (87%) and accompanied by a motor deficit in 61% of cases, cerebral CT is performed in 94% of cases. Hydrocephalus was present in 83% of patients, orthopedic disorders were found in 75% of cases, 90% of cases studied underwent surgery for the malformation and 83% benefited from ventriculoperitoneal shunting. Our results are similar to those reported in the literature, with a 100% rate of patients operated on in developed countries, and MMG frequently located in the lumbar region. The rate of hydrocephalus associated with MMG is 88%, the associated orthopedic malformations according to other studies vary from 46% to 93.9%, and the rate of patients benefiting from a DVP varies between 60% and 90%. Improving the long-term prognosis requires the collaboration of neurosurgeons, urologists, orthopedists, psychologists, physiotherapists and parents, which will facilitate the patient’s autonomy and social integration.

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The Timing of Primary Neurosurgical Repair and Wound-Site Infection in Children with Myelomeningocele

Obande,

Bitrus,

Obande

2024

OJMN

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Background: The optimal time to closure of a newborn with a myelomeningocele has been the focus of a number of evaluations. The Timing of primary surgery has received significant attention due to its relationship to repair-site infection that can lead to increased morbidity and prolonged hospital stays. It is on this basis that recommendations have utilized 48 -72 hours post birth as ideal time of closure. This is not only prevent infection at the site but also prevent ventriculitis and neural structure damage. We therefore, hypothesized an increase in wound infection rates in those patients with delays in

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Demographic and Clinical Characteristics of 63 Children with Myelomeningoceles

Cited by 3 publications

References 13 publications

Association of Location of Cyst with the family history and Mutated Gene among patients of Myelomeningocele

Association of Location of Cyst with the family history and Mutated Gene among patients of Myelomeningocele

Myelomeningocele about 100 Cases and Review of Literature

The Timing of Primary Neurosurgical Repair and Wound-Site Infection in Children with Myelomeningocele

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