Demographic and Clinical Features of Patients with Dengue in Northeastern Region of India: A Retrospective Cross-Sectional Study during 2009-2011

Abstract

The incidence of fever cases of unknown origin has increased in Northeastern Region of India in recent years. We conducted passive surveillance and performed laboratory testing on suspected cases for the presence of dengue infection during 2009-2011. We estimated the incidence by applying age, sex and season adjusted dengue positivity. We identified 430 suspected cases of which 143 (33.3%) were found to be laboratory-confirmed dengue cases. Dengue transmission was found to occur in post-monsoon season (September-December). We evaluated the differences of clinical features and hematologic abnormalities that occurred in laboratory dengue positive and negative cases. Significantly higher percentage of dengue patients had headache, eye pain and vomiting (P < 0.05). Diarrhoea as well as abdominal pain was observed more commonly in laboratory dengue negative patients but the difference was not significant (P > 0.05). Thrombocytopenia was observed in significantly higher percentage of positive patients (P < 0.001) with significantly lower platelets counts (P < 0.001). The elevated level of Aspartate transaminase (P < 0.001) and Alanine transaminase (P = 0.002) was also significantly higher side in positive patients. This study provides some important information in clinical and laboratory data that can be used for early diagnosis and subsequently for appropriate treatment of dengue infections. Thus, the passive surveillance and laboratory confirmation provides a better estimate of the actual dengue disease burden and a scope to further refine dengue prevention strategies.

Serological and Epidemiological Picture of Dengue during the Year 2014: An Exclusive Study of Kutch District, Gujarat, India

“….67%) were slightly higher than the rural (362, 46.65%) areas. Although previous studies from Gujarat & India showed that prevalence of dengue cases were much higher in urban areas; difference here in the present study is much less Madhulika Mistry et al, 2015;Durani et al, 2014;Patankar et al, 2014;Dutta et al, 2012;Khan et al, 2014. One reason for this can be natural demography of Kutch region where majority of population lives in rural areas as per Census 2011 data (Government of India, 2011 Census).…”

Retrospective Analysis of Demographic and Clinical Profile of Dengue Infection in a Tertiary Care Hospital

“…Majority of the patients were from Coimbatore and nearby districts. In relation to occupational profile our study differs from the study by Prafulla Datta et al where majority of the patients were blue collar workers (7). This was because their study population was from a rural location and ours is from an urban location.…”

Vigilance to Limit the Bidirectional Introduction and Co-circulation of Virus Serotypes Aims to Reduce Risk of Severe Dengue Disease in North East India

“…All serotypes were identified in the RT-PCR samples and DENV-1 was predominant (45.1%) [42]. Dual infections were also detected: DENV-1 and DENV-2 (3 cases); DENV-1 and DENV-3 (1 case); DENV-1 and DENV-4 (1 case); and DENV-2 and DENV-3 (3 cases) [42].…”

“…Of these, 89 were tested by RT-PCR and dengue was detected in 35: 27 instances of single serotype infection of DENV-3; 7 dual infections of DENV-1 and DENV-3; and one case of DENV-2 and DENV-3 mixed infection [36]. A retrospective surveillance study of 430 suspected dengue cases during 2009-2011 found 143 to be dengue positive (92 by IgM-capture ELISA and 51 by RT-PCR); these were collected from Assam (82), Meghalaya (35), Nagaland (15), Manipur (8) and Arunachal Pradesh (3) [42]. All serotypes were identified in the RT-PCR samples and DENV-1 was predominant (45.1%) [42].…”

“…A retrospective surveillance study of 430 suspected dengue cases during 2009-2011 found 143 to be dengue positive (92 by IgM-capture ELISA and 51 by RT-PCR); these were collected from Assam (82), Meghalaya (35), Nagaland (15), Manipur (8) and Arunachal Pradesh (3) [42]. All serotypes were identified in the RT-PCR samples and DENV-1 was predominant (45.1%) [42]. Dual infections were also detected: DENV-1 and DENV-2 (3 cases); DENV-1 and DENV-3 (1 case); DENV-1 and DENV-4 (1 case); and DENV-2 and DENV-3 (3 cases) [42].…”