Demographic, clinical and allergological characteristics of Eosinophilic Esophagitis in a Spanish central region

Jiménez, Ángela Conchillo; Torrijos, Elisa Gómez; Rodríguez, Raúl Rodríguez; Brito, Francisco Feo; Segade, J Borja; Bonilla, P A Galindo; Rodríguez-Sánchez, Joaquín; Pasadas, Francisco Guerra

doi:10.1016/j.aller.2013.04.004

Cited by 30 publications

(27 citation statements)

References 26 publications

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“…A higher prevalence of sensitization to food extracts has been detected by ImmunoCAP than by skin prick testing in both adults and children [9,27]. A similar situation was observed in our series ( Table 1).…”

Section: Discussionsupporting

confidence: 90%

“…The demographic characteristics of the series of children and adolescents with EoE described in this study match those reported by other authors [9,12]. EoE is more common in white males and in our series it was much more common in those who lived in an urban rather than a rural area.…”

Section: Discussionsupporting

confidence: 89%

“…Symptoms of esophageal dysfunction [9] and other common digestive symptoms in children with EoE were recorded ( Table 1) together with clinical symptoms related to the ingestion of the most frequent foods involved in EoE.…”

Section: Clinical Assessment and Comorbidities (Allergic And Digestivmentioning

confidence: 99%

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Eosinophilic Esophagitis: Demographic, Clinical, Endoscopic, Histologic, and Atopic Characteristics of Children and Teenagers in a Region in Central Spain

Torrijos

Miranda

Palencia

et al. 2017

J Investig Allergol Clin Immunol

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Background and objective: Eosinophilic esophagitis (EoE) is an increasingly prevalent chronic inflammatory disease of the esophagus with an immunoallergic etiology. Few studies have been published on EoE in children and adolescents. The objective of this study was to analyze the demographic, clinical, serologic, endoscopic-histologic, and atopic characteristics of pediatric patients with EoE and to identify atopic and digestive comorbidities. Methods: We conducted a prospective observational study in children and adolescents (<16 years) assessed in a specialized multidisciplinary EoE unit in a tertiary referral hospital in a central region of Spain between 2011 and 2015. Results: Thirty-five patients were included in the study. Twenty-eight (80%) were male. The mean age was 9.6 years, 83% were atopic, and 28% reported a family history of atopy. The most common symptom was dysphagia (51%). Eosinophilia was detected in the blood of 60% of patients. Eosinophil cationic protein and total IgE were elevated in 88% and 77% of patients, respectively. The most frequent endoscopic finding was linear grooves (57%). Skin tests with aeroallergens were positive in 82% of patients (pollen 62% and food 60%). The main atopic comorbidities were asthma (48%) and rhinoconjunctivitis (37%). Digestive diseases were more often associated with gastritis and Helicobacter pylori infection (17%). Conclusions: Our results are similar to those previously reported. EoE is more common in boys and in individuals with a history of atopy and sensitization to airborne allergens and food. These results support the consideration of EoE as an atopic disease and underline the important role of allergists in early diagnosis and treatment.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

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Eosinophilic Esophagitis: Demographic, Clinical, Endoscopic, Histologic, and Atopic Characteristics of Children and Teenagers in a Region in Central Spain

Torrijos

Miranda

Palencia

et al. 2017

J Investig Allergol Clin Immunol

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“…6 In our patient, the EoE did not subside with high doses of IBPs, and, after explaining to him the possible treatments (corticosteroids or diet), he chose the elimination diet. 7 Since results of allergy testing against the most frequently involved foods were negative, the patient was prescribed a 6FED.…”

Section: Discussionmentioning

confidence: 65%

Eosinophilic Esophagitis due to Gluten without Celiac Disease and Unusual Comorbidities

Elisa¹,

Díaz²,

Lozano³

et al. 2017

Exploratory Research and Hypothesis in Medicine

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In recent years, it has become recognized that patients with eosinophilic esophagitis (EoE) have an increased risk of multiple autoimmune diseases. Possible shared genetic aetiologies have been observed between EoE and autoimmune diseases. Currently, it is believed that EoE is not associated with a higher risk of neoplasms since such published cases are very rare and there are only isolated reports. Herein, we describe a unique case of EoE due to gluten without coeliac disease. The patient presented some unusual comorbidities, such as hypothyroidism (autoimmune disease) and essential thrombocythemia (neoplasm of haematologic origin).

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“…There were no randomized studies. One article was a case report, 33 two were case series, 30,34 one was a cross sectional study, 35 nine were case-control, 36-44 and six were cohort studies. 45-50 All articles were written in the last decade, with the earliest published in 2007.…”

Section: Resultsmentioning

confidence: 99%

The Role of Environmental Exposures in the Etiology of Eosinophilic Esophagitis

Green

Cotton

Dellon

2015

Mayo Clinic Proceedings

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Eosinophilic esophagitis (EoE) is an emerging clinicopathologic entity defined by abnormal esophageal eosinophilic infiltration. Management of this disease is hampered by limited understanding of etiologic and controllable risk factors. The aim of this systematic review was to determine the environmental risk factors for EoE. We searched PubMed, Web of Science, and EMBASE databases from 1950 through June 30, 2015. To identify additional relevant studies, we hand searched bibliographies of included articles. We limited the review to articles using human subjects, and consisting of case reports, case series, cross-sectional and cohort studies, or clinical trials. 19 articles discuss the risk of environmental exposures on EoE and indicate that environment plays a large role in the etiology of EoE. Seasonal, geographic, and climate-based differences in disease prevalence have been shown but the exact mediators of this process, possibly aeroallergens that vary over time and from place to place, remains elusive.

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Demographic, clinical and allergological characteristics of Eosinophilic Esophagitis in a Spanish central region

Cited by 30 publications

References 26 publications

Eosinophilic Esophagitis: Demographic, Clinical, Endoscopic, Histologic, and Atopic Characteristics of Children and Teenagers in a Region in Central Spain

Eosinophilic Esophagitis: Demographic, Clinical, Endoscopic, Histologic, and Atopic Characteristics of Children and Teenagers in a Region in Central Spain

Eosinophilic Esophagitis due to Gluten without Celiac Disease and Unusual Comorbidities

The Role of Environmental Exposures in the Etiology of Eosinophilic Esophagitis

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