Demographic differences in the frequencies of scleroderma‐related autoantibodies

Picillo, U; Migliaresi, S.; Vatti, M; Marcialis, M. R.; Ferruzzi, Anna Maria; Tim, Giuseppe

doi:10.1002/art.1780360920

Cited by 17 publications

(7 citation statements)

References 6 publications

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“…Hispanic-Americans with SSc also may show a higher frequency of this autoantibody; however, the number of such patients in this study was too small to adequately assess an association. Thus, antifibrillarin, like anti-top0 I and anti-U1 RNP, may show significant racial differences in its frequency of expression in SSc patients (43)(44)(45). In addition, as reported previously (4,14), males were again overrepresented among antifibrillarinpositive patients compared with their negative counterparts.…”

Section: Discussionsupporting

confidence: 58%

Autoantibodies to fibrillarin in systemic sclerosis (scleroderma). An immunogenetic, serologic, and clinical analysis

Goldstein

et al. 1996

Arthritis & Rheumatism

169

134

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Objective. To determine the frequency, clinical associations, and any major histocompatibility complex correlations of antifibrillarin antibodies in patients with systemic sclerosis (SSc).Methods. Antifibrillarin antibodies were determined by indirect immunofluorescence, immunoblotting, and immunoprecipitation, and HLA class I1 alleles by DNA oligotyping, in a large cohort of SSc patients.Results. Antifibrillarin was found in 8% of 335 SSc sera and was significantly more common in blacks (16%) than whites (S%), in males (33%) than females (14%), and in patients with cardiac, renal, or gut involvement. The HLA class I1 haplotype DRBZ *Z302, DQBZ*0604 was found significantly more frequently in SSc patients with antifibrillarin compared with racematched normal controls and 260 SSc patients without antifibrillarin. In addition, 1 or more of the HLA-DQB1

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Section: Discussionsupporting

confidence: 58%

Autoantibodies to fibrillarin in systemic sclerosis (scleroderma). An immunogenetic, serologic, and clinical analysis

Goldstein

et al. 1996

Arthritis & Rheumatism

169

134

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“…In a comprehensive epidemiologic study of women who were residents of Michigan between 1980 and 1991, the annual incidence of SSc was 22.5 per million population at risk in African Americans compared with 12.8 per million in Caucasians (2). Prior studies have shown that African American patients with SSc are younger at disease onset, are diagnosed at an earlier age, and more frequently have diffuse scleroderma (2, 7–9, 24) and interstitial lung disease (3, 10).…”

Section: Discussionmentioning

confidence: 99%

“…Consistent with this finding, the frequency of serum autoantibodies differs between African American and Caucasian patients with SSc. Anti–topo I is somewhat more frequently detected in African American patients with SSc (6–10). Anti–U3 RNP antibodies are particularly common in African American patients with SSc (10–12).…”

mentioning

confidence: 99%

A clinical and serologic comparison of African American and Caucasian patients with systemic sclerosis

Steen¹,

Domsic²,

Lucas³

et al. 2012

Arthritis & Rheumatism

158

112

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Objective Epidemiology studies suggest that Systemic Sclerosis is more common, occurs at a younger age and is more severe in African-Americans than Caucasians. However, the scleroderma autoantibody profile is very different between these two ethnic subgroups. This study examines the demographic and disease features, frequency and severity of internal organ system involvement and survival in African-American and Caucasian SSc patients with particular attention to their serum autoantibody profiles. Methods Demographic, clinical, autoantibody, natural history of organ involvement and survival were studied in consecutive African-American and Caucasian patients seen between 1972 and 2007 as part of the Pittsburgh Scleroderma Database. The Medsger Disease Severity Scale was used to determine severe disease. Results African-American patients were more likely to have anti topoisomerase, anti U1RNP and U3 RNP auto-antibodies. Comparing African-American and Caucasians with these antibodies, African-American patients with anti topoisomerase antibody had more frequent and more severe pulmonary fibrosis than Caucasians and an associated decreased survival. Pulmonary fibrosis was also more severe in the U1 RNP patients but was not associated with a difference in survival between African Americans and Caucasians. Anti U3 RNP was associated with more severe gastrointestinal involvement in African-American’s compared to Caucasians. Conclusions African Americans with systemic sclerosis have more severe disease complications than Caucasians both because of the type of autoantibody they have and because they have more severe interstitial lung disease even within the antibody subset. Early aggressive intervention in all African Americans with interstitial lung disease should be a priority.

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“…Nevertheless, among the 38 uranium miners with definite SSc, the ATA frequency is still higher (42.1%) compared to idiopathic SSc. This difference may not be gender-related (most of the patients with idiopathic SSc are women) since ATA was found equally among males and females in other studies [35,36]. Variations in genetic determinants may result in different responses to different triggering mechanisms.…”

Section: Diagnostic and Prognostic Relevance Of Aab Typical Of Ctd Inmentioning

confidence: 92%

Diagnostic and Prognostic Relevance of Autoantibodies in Uranium Miners

Conrad¹,

Mehlhorn²

2000

Int Arch Allergy Immunol

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Uranium miners exposed to silica dust have a higher risk of developing systemic sclerosis (SSc) and systemic lupus erythematosus (SLE). Sera of 1976 former uranium miners were analysed for autoantibodies typical of connective tissue disease. The frequency of some of these antibodies (anti-centromere, -topoisomerase I, -nucleolar, -dsDNA, -Ro/SSA, -La-SSB and U1-RNP antibodies) was significantly higher compared to a gender- and age-matched control group and was associated with the intensity of exposure as well as with clinical symptoms of SSc or SLE. It was also shown that SSc-associated autoantibodies may serve as an early indicator of disease development. Some differences in the autoantibody production between silica-dust-associated and idiopathic SLE/SSc were observed that might be caused by environmental factors in the population of uranium miners.

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Demographic differences in the frequencies of scleroderma‐related autoantibodies

Cited by 17 publications

References 6 publications

Autoantibodies to fibrillarin in systemic sclerosis (scleroderma). An immunogenetic, serologic, and clinical analysis

Autoantibodies to fibrillarin in systemic sclerosis (scleroderma). An immunogenetic, serologic, and clinical analysis

A clinical and serologic comparison of African American and Caucasian patients with systemic sclerosis

Diagnostic and Prognostic Relevance of Autoantibodies in Uranium Miners

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