Demonstration of Fc Receptors on the Surface of B Lymphocytes

Sandilands, G. P.; Gray, Kathleen; Reid, Fiona; Anderson, John R.

doi:10.1159/000232132

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…It therefore seems likely that this phenomenon is confined to a particular Fcy-receptor bearing lymphocyte subpopulation since the level of EA+ PBL rarely fell by more than 50%. Human B lymphocytes possess Fcy-receptors of relatively low avidity for EA as compared with these non-B lymphocytes with Fcy-receptors [2,10,13]. This latter group with high avidity Fcy-receptors, containing the effector cells in antibody-dependent cell cytotoxicity (K cells) [12] and a proportion of T (suppressor?)…”

Section: Discussionmentioning

confidence: 99%

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In vivo Modulation of Human Lymphocyte Fcγ-Receptors in Response to Oral Antigen (Cows’ Milk) Challenge

Sandilands¹,

Reid²,

Galbraith³

et al. 1982

Int Arch Allergy Immunol

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Following consumption of 1.2 litres of cows’ milk by normal human adults there was a rapid fall in the proportion of peripheral blood lymphocytes bearing receptors for the reacted Fc of IgG (Fcγ-receptors). This phenomenon was transient and apparently confined to the lymphocyte Fcγ-receptor^+ve subpopulation. Similar observations were made in rats but only in those animals pre-exposed to cows’ milk suggesting that an immunological mechanism is involved. In man it was found that Fcγ-receptors could only be re-expressed following incubation of post-milk lymphocytes in normal human serum. It is proposed that rapid in vivo modulation of lymphocyte Fcγ-receptors occurs following oral antigen (cows’ milk) challenge probably mediated by soluble food antigen-antibody complexes. The subsequent recovery of these receptors in vivo and in vitro may be due to the binding of ‘fluid-phase’ Fcγ-receptors found in normal human serum.

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Section: Discussionmentioning

confidence: 99%

“…B cell SIg was measured by indi rect immunofluorescence using polyvalent rabbit anti-human Ig serum (previously absorbed with human thymocytes) and with flu orescein-conjugated goat antiserum to rabbit Ig (Behringwerke AG, Marburg, FRG) [ 13].…”

Section: Measurement O F Leucocyte Surface Receptorsmentioning

confidence: 99%

In vivo Modulation of Human Lymphocyte Fcγ-Receptors in Response to Oral Antigen (Cows’ Milk) Challenge

Sandilands¹,

Reid²,

Galbraith³

et al. 1982

Int Arch Allergy Immunol

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Fc receptor—More answers, more questions

Fornůsek

Větvička

1984

Folia Microbiol

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Fc receptors, belonging to the most important surface structures of a number of cells participating in the immune processes, have been intensely studied during the past decade. The present review summarizes the contemporary knowledge of the specificity and heterogeneity of Fc receptors and of factors influencing their expression, and includes some views on their function. In addition, it mentions their relationship to other cell surface structures, expression of Fc receptors during ontogeny of the organism and in certain diseases. Finally, data concerning the isolation and biochemical characterization of the Fc receptor molecule are presented.

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