Demonstration of intracytoplasmic immunoglobulin in non-T-acute lymphocytic leukemia cases of children with immunoelectron microscopic examination

Mori, Naoyoshi; Oka, Kuniyuki; Hanada, Takashi; Iizuka, Akira; Kojima, Mizu

doi:10.1002/1097-0142(19880601)61:11<2231::aid-cncr2820611117>3.0.co;2-w

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…When a tumour is MTl + alone the lineage is indeterminate. Ig is difficult to demonstrate, but with sensitive methods perinuclear space IgM can be shown in even pre-B-cell tumours (Mori et al 1988). Lastly a novel method for showing terminal deoxynucleotidyl transferase in routinely processed tissue promises to improve diagnostic accuracy of the lymphoblastic group (Said, Shintaku & Pinkus 1988).…”

Section: High-grade B-cell Lymphomamentioning

confidence: 99%

Lymphoma phenotyping in formalin‐fixed and paraffin wax‐embedded tissues: II. Profiles of reactivity in the various tumour types*

Norton

Isaacson

1989

Histopathology

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Recently, monoclonal antibodies capable of phenotyping malignant lymphomas in routinely fixed and processed tissue have become available. Some of these reagents identify lineage-restricted variants of the leucocyte common molecule, whereas others identify unique fixation-resistant epitopes on lymphoid cells, some of which are shared by non-lymphoid tissues. A new generation of antibodies recognizing 'classical' leucocyte antigens such as CD3 are also emerging. Refinements in antigen detection systems, especially for immunoglobulin recognition, combined with these new reagents promise to improve the accuracy of lymphoma diagnosis in routine histopathology. These new antibodies are reviewed, and their limitations, cross reactivities and profiles of staining in lymphoreticular disease are discussed. A strategy for their optimal use is proposed.

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Section: High-grade B-cell Lymphomamentioning

confidence: 99%

Lymphoma phenotyping in formalin‐fixed and paraffin wax‐embedded tissues: II. Profiles of reactivity in the various tumour types*

Norton

Isaacson

1989

Histopathology

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Predominant expression of lambda light chain in adult cases with non-T-cell acute lymphocytic and chronic myelogenous leukemia in lymphoid blast crisis

Mori

Oka²,

Yoda

et al. 1991

Cancer

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The authors investigated cytoplasmic immunoglobulins of the leukemic cells from 20 adult cases with non-T-cell acute lymphocytic leukemia (ALL) and from three cases with chronic myelogenous leukemia in lymphoid blast crisis using immunoelectron microscopy. They also studied these cases using various monoclonal antibodies. Of the 23 examined cases, nine were negative for both heavy and light chains of immunoglobulins; the authors defined these as common ALL. Two cases were positive for the mu chain but were negative for light chains; the authors defined these as pre-B-cell ALL. The remaining 12 cases were positive for either kappa or lambda light chains; these were defined as B-cell ALL. Of the 12 cases positive for light chains, 11 were positive for the lambda chain. Seven cases of the 11 positive cases for the lambda chain were negative for heavy chains. Eleven cases were positive either for both My4 and My9 or for one of the two antibodies. From these results, the authors conclude the following: (1) the ratio of pre-B-cell ALL among non-T-cell ALL cases (two of 23 cases) was lower in adults than in children; (2) of the light chain-positive cases, the lambda light chain-positive cases predominated (11 of 12 cases); (3) heavy chain-negative, lambda chain-positive cases (seven cases) were observed; and (4) one half of the leukemia cases showed dual phenotypes of B-cell and myeloid cell lineages.

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Cutaneous Malignant Lymphoma in an Infant

Umebayashi

Nameki

Saito

et al. 1990

The Journal of Dermatology

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A case of cutaneous malignant lymphoma in a 7-month-old infant is described. The skin was the only apparent organ involved. Immunophenotypic studies revealed that the infiltrate was positive for B4 (CD19), J5 (CD10), and cytoplasmic mu chain, and lambda chain, but negative for B1 (CD20). The significance of these findings is discussed. We believed the tumor was of B-cell origin. The reported cases of cutaneous malignant lymphoma in infancy are briefly reviewed.

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Demonstration of intracytoplasmic immunoglobulin in non-T-acute lymphocytic leukemia cases of children with immunoelectron microscopic examination

Cited by 3 publications

References 21 publications

Lymphoma phenotyping in formalin‐fixed and paraffin wax‐embedded tissues: II. Profiles of reactivity in the various tumour types*

Lymphoma phenotyping in formalin‐fixed and paraffin wax‐embedded tissues: II. Profiles of reactivity in the various tumour types*

Predominant expression of lambda light chain in adult cases with non-T-cell acute lymphocytic and chronic myelogenous leukemia in lymphoid blast crisis

Cutaneous Malignant Lymphoma in an Infant

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