Dendrimer-entrapped gold nanoparticles modified with RGD peptide and alpha-tocopheryl succinate enable targeted theranostics of cancer cells

Zhu, Jingyi; Fu, Fanfan; Xiong, Zhijuan; Shen, Mingwu; Shi, Xiangyang

doi:10.1016/j.colsurfb.2015.05.040

Cited by 70 publications

(32 citation statements)

References 53 publications

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“…For example, the gold (Z = 79) has much stronger photoelectric effect than that of soft tissues (average Z = 7.4). [31][32][33][34][35][36][37][38][39] Au loaded polymeric nanocapsules [40][41][42][43] Au nanomolecules [40,44,45] Active targeting Au nanoparticles [44,[46][47][48][49][50] Rare earth element Gadolinium oxide; Gd doped carbon dots; Gd doped calcium phosphate [51][52][53][54] Upconversion nanoparticles (e.g. Such electron rearrangement in atom orbits would generate excess energy that released either as fluorescent photons or Auger electrons, the latter of which traveling through much shorter distances (typically ≈10 nm) are able to produce high ionization effects in local areas.…”

Section: Mechanisms Of Radio-sensitization With High-z Elementsmentioning

confidence: 99%

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

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Radiation therapy (RT) including external beam radiotherapy (EBRT) and internal radioisotope therapy (RIT) has been widely used for clinical cancer treatment. However, owing to the low radiation absorption of tumors, high doses of ionizing radiations are often needed during RT, leading to severe damages to normal tissues adjacent to tumors. Meanwhile, the RT efficacies are limited by different mechanisms, among which the tumor hypoxia-associated radiation resistance is a well-known one, as there exists hypoxia inside most solid tumors while oxygen is essential to enhance radiation-induced DNA damages. With the development in nanotechnology, there have been great interests in using nanomedicine strategies to enhance radiation responses of tumors. Nanomaterials containing high-Z elements to absorb radiation rays (e.g. X-ray) can act as radio-sensitizers to deposit radiation energy within tumors and promote treatment efficacy. Nanoscale carriers are able to deliver therapeutic radioisotopes into tumors for internal RIT, or chemotherapeutic drugs for synergistically combined chemo-radiotherapy. As uncovered in recent studies, the tumor microenvironment could be modulated by various nanomedicine approaches to overcome hypoxia-associated radiation resistance. Herein, the authors will summarize the applications of nanomedicine for RT cancer treatment, and pay particular attention to the latest development of 'advanced materials' for enhanced cancer RT.

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Section: Mechanisms Of Radio-sensitization With High-z Elementsmentioning

confidence: 99%

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

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“…Construction of dendrimer-drug conjugates with degradable linkages between the dendrimers and drug by stimuli-cleavable is a promising approach to control the release of drug. On the other hand, only few drugs can take effect without linkage broken [57][58][59]. Hydrazone bond is widely utilized for exploiting acid-responsive dendrimer-drug conjugates as prodrugs ( Fig.…”

Section: Dendrimer-drug Conjugates In Chemotherapymentioning

confidence: 99%

Dendrimer-based nanoparticles in cancer chemotherapy and gene therapy

et al. 2018

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This review discusses recent studies on dendrimer-based nanoparticles in cancer chemotherapy and gene therapy. In order to achieve the high efficacy and low side effects of chemotherapy and gene therapy, it is essential to combine the unique features of dendrimers and the specific tumor microenvironment to target delivery and control release of therapeutic agents to tumor tissues and cells. Strategies to design the dendrimer-based delivery system in this review include non-modified dendrimers, dendrimer conjugates, assembled amphiphilic dendrimers, nanohybrid dendrimer carriers and dendrimers with inherent activity. In addition, specific functional groups on these dendrimers as stimuli-responsive system for targeting delivery and controlled release of therapeutic agents are discussed.

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“…However, considering the imaging principle of measuring the X-ray beam attenuation through the body, CT obtains poor soft-tissue contrast and hence CAs are necessary to complete the mission of theranostics, such as measuring therapy response and monitoring therapeutic process 79 . CT CAs must have high atomic number, including iodinated compounds 80 , barium complex 81 , gold nanoparticles (Au NPs) 82 , and so on. Through encapsulation or conjugation, dendritic polymers are promising delivery vehicles for carrying CT CAs along with drugs.…”

Section: Introductionmentioning

confidence: 99%

Dendritic Polymers for Theranostics

et al. 2016

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Dendritic polymers are highly branched polymers with controllable structures, which possess a large population of terminal functional groups, low solution or melt viscosity, and good solubility. Their size, degree of branching and functionality can be adjusted and controlled through the synthetic procedures. These tunable structures correspond to application-related properties, such as biodegradability, biocompatibility, stimuli-responsiveness and self-assembly ability, which are the key points for theranostic applications, including chemotherapeutic theranostics, biotherapeutic theranostics, phototherapeutic theranostics, radiotherapeutic theranostics and combined therapeutic theranostics. Up to now, significant progress has been made for the dendritic polymers in solving some of the fundamental and technical questions toward their theranostic applications. In this review, we briefly summarize how to control the structures of dendritic polymers, the theranostics-related properties derived from their structures and their theranostics-related applications.

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Dendrimer-entrapped gold nanoparticles modified with RGD peptide and alpha-tocopheryl succinate enable targeted theranostics of cancer cells

Cited by 70 publications

References 53 publications

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Dendrimer-based nanoparticles in cancer chemotherapy and gene therapy

Dendritic Polymers for Theranostics

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