Dendritic cells reprogrammed by CEA messenger RNA loaded multi-functional silica nanospheres for imaging-guided cancer immunotherapy

“…[ 165 ] Nanoparticles currently available for in vivo DC imaging mainly include QDs, iron nanoparticles, and polymeric nanoparticles. [ 166,167 ] DCs can be tracked through fluorescence imaging, MRI, ultrasound imaging, among other techniques, to observe their migration to lymph nodes and formulate the most appropriate treatment plan. [ 168 ] In 2015, Wu et al.…”

Section: Imaging Of Immune Cellsmentioning

confidence: 99%

Emerging Biomaterials Imaging Antitumor Immune Response

Zhang

Wang

et al. 2022

Advanced Materials

View full text Add to dashboard Cite

Immunotherapy is one of the most promising clinical modalities for the treatment of malignant tumors and has shown excellent therapeutic outcomes in clinical settings. However, it continues to face several challenges, including long treatment cycles, high costs, immune‐related adverse events, and low response rates. Thus, it is critical to predict the response rate to immunotherapy by using imaging technology in the preoperative and intraoperative. Here, the latest advances in nanosystem‐based biomaterials used for predicting responses to immunotherapy via the imaging of immune cells and signaling molecules in the immune microenvironment are comprehensively summarized. Several imaging methods, such as fluorescence imaging, magnetic resonance imaging, positron emission tomography imaging, ultrasound imaging, and photoacoustic imaging, used in immune predictive imaging, are discussed to show the potential of nanosystems for distinguishing immunotherapy responders from nonresponders. Nanosystem‐based biomaterials aided by various imaging technologies are expected to enable the effective prediction and diagnosis in cases of tumors, inflammation, and other public diseases.

show abstract

“…Positively charged mesoporous silica, which has been modified with 3-aminopropyltriethoxysilane, been shown to successfully load mRNA and quantum dots for targeted delivery to dendritic cells (DCs) and reprogrammed DCs. This targeted delivery has been demonstrated to trigger effective anticancer immunity in vivo 110. …”

mentioning

confidence: 99%

Advancing mRNA Therapeutics: The Role and Future of Nanoparticle Delivery Systems

Li,

Zhang,

Yang

et al. 2024

Mol. Pharmaceutics

View full text Add to dashboard Cite

The coronavirus (COVID-19) pandemic has underscored the critical role of mRNA-based vaccines as powerful, adaptable, readily manufacturable, and safe methodologies for prophylaxis. mRNA-based treatments are emerging as a hopeful avenue for a plethora of conditions, encompassing infectious diseases, cancer, autoimmune diseases, genetic diseases, and rare disorders. Nonetheless, the in vivo delivery of mRNA faces challenges due to its instability, suboptimal delivery, and potential for triggering undesired immune reactions. In this context, the development of effective drug delivery systems, particularly nanoparticles (NPs), is paramount. Tailored with biophysical and chemical properties and susceptible to surface customization, these NPs have demonstrated enhanced mRNA delivery in vivo and led to the approval of several NPs-based formulations for clinical use. Despite these advancements, the necessity for developing a refined, targeted NP delivery system remains imperative. This review comprehensively surveys the biological, translational, and clinical progress in NPs-mediated mRNA therapeutics for both the prevention and treatment of diverse diseases. By addressing critical factors for enhancing existing methodologies, it aims to inform the future development of precise and efficacious mRNAbased therapeutic interventions.

show abstract

Dendritic cells reprogrammed by CEA messenger RNA loaded multi-functional silica nanospheres for imaging-guided cancer immunotherapy

Cited by 7 publications

References 35 publications

Tumor-targeted nano-delivery system of therapeutic RNA

Tumor-targeted nano-delivery system of therapeutic RNA

Emerging Biomaterials Imaging Antitumor Immune Response

Advancing mRNA Therapeutics: The Role and Future of Nanoparticle Delivery Systems

Contact Info

Product

Resources

About