Dendritic organosilica nanospheres with large mesopores as multi-guests vehicle for photoacoustic/ultrasound imaging-guided photodynamic therapy

Huang, Yuting; Shen, Kaiwen; Si, Yinsong; Shan, Chun; Guo, Hongchong; Chen, Min; Wu, Limin

doi:10.1016/j.jcis.2020.09.028

Cited by 26 publications

(20 citation statements)

References 50 publications

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“…20,21 Among them, AuNR coated with the mesoporous silica shell (AuNR/ SiO 2 ) exhibited a great potential to realize chemo-photothermal therapy due to their uniform pore size, high biocompatibility, and easy surface functionalization. [22][23][24] However, according to the classical protocol reported by Gorelikov, 25 the thickness of the silica shell is only $30 nm with disordered mesopores of $4 nm diameter, which cannot provide enough space for cargos, thereby limiting the size of the guests. As to improve the drug loading capacity, much work so far has focused on the "layer-by-layer" method 25 to increase the shell thickness, or "surface-protected etching" to produce the hollow structure.…”

Section: Introductionmentioning

confidence: 99%

Ultra-high thermally stable gold nanorods/radial mesoporous silica and their application in enhanced chemo-photothermal therapy

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Ultra-high thermally stable gold nanorods/radial mesoporous silica and their application in enhanced chemo-photothermal therapy

et al. 2021

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“…Upon light excitation, encapsulated ICG results in simultaneous PAI and PDT of in vivo tumor tissues, while the catalase molecules catalyze the decomposition of endogenous H 2 O 2 into O 2 bubbles to intensify US imaging signal and enhance PDT efficacy simultaneously. Thus, the results showed excitation of ICG-CAT@MONs causes enhanced tumor destruction due to the sustainable O 2 generation, eventually promoting PDT and holds promise in multimodal PA/US image-guided PDT 196 . In another exciting discovery, Sun and collaborators reported the synthesis of multifunctional PGL MBs loaded with HIF-1α siRNA (siHIF@CpMB) for PDT combined with gene therapy in triple-negative breast cancer therapy.…”

Section: Theranostics: ''Multifunctional Agents'' For Image-guided Photodynamic Therapymentioning

confidence: 91%

Recent Advances in Photosensitizers as Multifunctional Theranostic Agents for Imaging-Guided Photodynamic Therapy of Cancer

2021

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In recent years tremendous effort has been invested in the field of cancer diagnosis and treatment with an overall goal of improving cancer management, therapeutic outcome, patient survival, and quality of life. Photodynamic Therapy (PDT), which works on the principle of light-induced activation of photosensitizers (PS) leading to Reactive Oxygen Species (ROS) mediated cancer cell killing has received increased attention as a promising alternative to overcome several limitations of conventional cancer therapies. Compared to conventional therapies, PDT offers the advantages of selectivity, minimal invasiveness, localized treatment, and spatio-temporal control which minimizes the overall therapeutic side effects and can be repeated as needed without interfering with other treatments and inducing treatment resistance. Overall PDT efficacy requires proper planning of various parameters like localization and concentration of PS at the tumor site, light dose, oxygen concentration and heterogeneity of the tumor microenvironment, which can be achieved with advanced imaging techniques. Consequently, there has been tremendous interest in the rationale design of PS formulations to exploit their theranostic potential to unleash the imperative contribution of medical imaging in the context of successful PDT outcomes. Further, recent advances in PS formulations as activatable phototheranostic agents have shown promising potential for finely controlled imaging-guided PDT due to their propensity to specifically turning on diagnostic signals simultaneously with photodynamic effects in response to the tumor-specific stimuli. In this review, we have summarized the recent progress in the development of PS-based multifunctional theranostic agents for biomedical applications in multimodal imaging combined with PDT. We also present the role of different imaging modalities; magnetic resonance, optical, nuclear, acoustic, and photoacoustic in improving the pre-and post-PDT effects. We anticipate that the information presented in this review will encourage future development and design of PSs for improved image-guided PDT for cancer treatment.

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“…It catalyzes the transformation of H 2 O 2 to water and oxygen. It is widely used in the construction of nanosystems for hypoxic tumor PDT [ 150 , 151 , 152 , 153 , 154 ]. For instance, catalase was co-encapsulated with a photosensitizer MBDP and a chemotherapeutic drug doxorubicin to obtain FA-L@MD@CAT [ 155 ].…”

Section: Strategies For Modulating Tumor Hypoxia In Pdtmentioning

confidence: 99%

Recent Advances in Strategies for Addressing Hypoxia in Tumor Photodynamic Therapy

Liang

Luo

et al. 2022

Biomolecules

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Photodynamic therapy (PDT) is a treatment modality that uses light to target tumors and minimize damage to normal tissues. It offers advantages including high spatiotemporal selectivity, low side effects, and maximal preservation of tissue functions. However, the PDT efficiency is severely impeded by the hypoxic feature of tumors. Moreover, hypoxia may promote tumor metastasis and tumor resistance to multiple therapies. Therefore, addressing tumor hypoxia to improve PDT efficacy has been the focus of antitumor treatment, and research on this theme is continuously emerging. In this review, we summarize state-of-the-art advances in strategies for overcoming hypoxia in tumor PDTs, categorizing them into oxygen-independent phototherapy, oxygen-economizing PDT, and oxygen-supplementing PDT. Moreover, we highlight strategies possessing intriguing advantages such as exceedingly high PDT efficiency and high novelty, analyze the strengths and shortcomings of different methods, and envision the opportunities and challenges for future research.

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Dendritic organosilica nanospheres with large mesopores as multi-guests vehicle for photoacoustic/ultrasound imaging-guided photodynamic therapy

Cited by 26 publications

References 50 publications

Ultra-high thermally stable gold nanorods/radial mesoporous silica and their application in enhanced chemo-photothermal therapy

Ultra-high thermally stable gold nanorods/radial mesoporous silica and their application in enhanced chemo-photothermal therapy

Recent Advances in Photosensitizers as Multifunctional Theranostic Agents for Imaging-Guided Photodynamic Therapy of Cancer

Recent Advances in Strategies for Addressing Hypoxia in Tumor Photodynamic Therapy

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