Dendritic self-avoidance: protocadherins have it covered

Hoang, Phuong Thi; Grueber, Wesley B.

doi:10.1038/cr.2012.137

Cited by 1 publication

(1 citation statement)

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“…Later on the same group proved that during Xenopus somitogenesis, the segmental boundaries are established by PAPC [21] . Recently, protocadherins have been intricately linked to an important cellular behavior exhibited by neuronal processes or dendrites called self-avoidance [22] . It refers to the property of axonal or dendritic projections to spread and cover large spatial territories without crossing its own branches.…”

Section: Introductionmentioning

confidence: 99%

Spatio-Temporally Restricted Expression of Cell Adhesion Molecules during Chicken Embryonic Development

Roy

Bandyopadhyay

2014

PLoS ONE

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Differential cell adhesive properties are known to regulate important developmental events like cell sorting and cell migration. Cadherins and protocadherins are known to mediate these cellular properties. Though a large number of such molecules have been predicted, their characterization in terms of interactive properties and cellular roles is far from being comprehensive. To narrow down the tissue context and collect correlative evidence for tissue specific roles of these molecules, we have carried out whole-mount in situ hybridization based RNA expression study for seven cadherins and four protocadherins. In developing chicken embryos (HH stages 18, 22, 26 and 28) cadherins and protocadherins are expressed in tissue restricted manner. This expression study elucidates precise expression domains of cell adhesion molecules in the context of developing embryos. These expression domains provide spatio-temporal context in which the function of these genes can be further explored.

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Section: Introductionmentioning

confidence: 99%