2019
DOI: 10.1155/2019/9310245
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Dendrobium Officinale Polysaccharides Protect against MNNG-Induced PLGC in Rats via Activating the NRF2 and Antioxidant Enzymes HO-1 and NQO-1

Abstract: Dendrobium officinale polysaccharides (DOP) are the main effective ingredient in Dendrobium officinale. Nuclear factor erythroid 2-related factor 2 (NRF2) signaling is regarded as an important way to mitigate the effects of reactive oxygen species (ROS) damage and inhibit gastric cancer progress. This study introduces a previously unknown effect of DOP on precancerous lesions of gastric cancer (PLGC). The mechanism discussed herein is based on the NRF2 signal pathway as well as its downstream antioxidant enzym… Show more

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Cited by 72 publications
(51 citation statements)
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“…In our experiment, the PLGC group can downregulate the expression of α-CEHC and after administering DOP, it upregulated, this result indicated the strong anti-oxidant capacity of DOP, and it was the same as the report [28]. In our previous study, we had certified that DOP could promote NRF2 into the nucleus and increase downstream anti-oxidant enzyme capacity [13].…”
Section: Discussionsupporting
confidence: 81%
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“…In our experiment, the PLGC group can downregulate the expression of α-CEHC and after administering DOP, it upregulated, this result indicated the strong anti-oxidant capacity of DOP, and it was the same as the report [28]. In our previous study, we had certified that DOP could promote NRF2 into the nucleus and increase downstream anti-oxidant enzyme capacity [13].…”
Section: Discussionsupporting
confidence: 81%
“…We found that the PLGC model rats had a side effect on liver function which increased the ALT level ( p < 0.001); high, medium, and low doses of DOP significantly decreased the level of ALT, which was statistically significant compared with the model group ( p < 0.01). The results indicate that DOP has a protective effect on liver function [13], which may be related with the upregulation of betaine by DOP, although further research is required. In another way, the report indicated betaine could attenuate DEN-induced hepatocarcinogenesis through the down-regulation of P 16 and inhibiting the up-regulation of c-Myc, which cued the betaine could has the inhibition on gastric carcinogenesis [25].…”
Section: Discussionmentioning
confidence: 99%
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“…NQO-1 exerts highly effective antioxidant functions and performs a cytoprotective role [49]. When oxidative stress is exerted, Nrf-2 is liberated from Keap-1 and is translocated into the nucleus, where it combines with ARE and activates the ARE-dependent transcription of phase II and antioxidant defense enzymes, including heme oxygenase-1 (HO-1) and NAD (P)H:quinone acceptor oxidoreductase 1 (NQO-1), attenuating cellular oxidative stress [50,51]. In the present study, we found that levels of Nrf-2 and NQO-1 proteins significantly decrease in both H 2 O 2 -induced BMSC death and the SCI rat model.…”
mentioning
confidence: 99%