“…In contrast to other countries, characterized by the cocirculation of several serotypes, Cuba represents a unique scenario to perform genetic studies of DHF resistance and susceptibility, with known clinical and serologic dengue markers in a population with a unique history of dengue virus epidemics [11,14,15,28]. Consequently, in this study, HLA-A, -B, class I, and HLA-DRB1 class II polymorphism were examined in Cuban individuals with history of DF or DHF in the course of both primary and secondary dengue 2 infections during the 1997 D2 outbreak, using PCR-based typing techniques.…”