Dengue encephalopathy – still an enigma?

Malik, Rupali; Gogna, Arun; Meher, J.; Singh, Kumud Kumar; Sharma, Susheel Kumar

doi:10.3855/jidc.4762

Cited by 5 publications

(2 citation statements)

References 5 publications

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“…For instance, West Nile virus and dengue virus infections cause pathological features in the thalamus, another main source of brain dopamine (Solomon, 2004; Sanchez-Gonzalez et al, 2005; Malik et al, 2014). Zika virus (ZIKV), a recent public health problem, has been linked to neonatal microcephaly in that ZIKV can target developing brain cells (Garcez et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Japanese Encephalitis Virus Exploits Dopamine D2 Receptor-phospholipase C to Target Dopaminergic Human Neuronal Cells

et al. 2017

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Despite the availability of vaccines for Japanese encephalitis virus (JEV), the re-emerging virus remains a clinically important pathogen that causes acute encephalitis and permanent neuropsychiatric sequels. JEV highly targets dopaminergic neuron-rich brain regions including the thalamus and midbrain. The molecular mechanism contributing to the high susceptibility of these particular brain regions remains largely unclear. This study addressed whether this tissue tropism of JEV is associated with signaling of dopaminergic neurons. Three pieces of evidence indicate that JEV exploits dopamine signaling to facilitate its infection: (1) JEV infection modulates dopamine level; (2) a selective dopamine D2 receptor (D2R) agonist enhances JEV infection; and (3) stimulation of D2R activates phospholipase C (PLC) to enhance the surface expression of JEV binding/entry molecules, integrin β3 and vimentin. Overall, JEV may exploit dopamine-mediated neuronal communication to increase the susceptibility of D2R-expressing cells to JEV infection. This study identifies a potential underlying mechanism of viral invasiveness in the dopaminergic brain regions and suggests antiviral strategies against viral infection by targeting D2R-PLC signaling.

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Section: Discussionmentioning

confidence: 99%

Japanese Encephalitis Virus Exploits Dopamine D2 Receptor-phospholipase C to Target Dopaminergic Human Neuronal Cells

et al. 2017

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“…Encephalopathy is a rare though well-known neurological complication of dengue infection. 3 Deaths following dengue infection amongst members of the Armed Forces are rare. This is because of regular epidemiological investigation, timely notification to higher echelons (unlike in the civil sector where dengue is not a notifiable disease), early diagnosis and treatment; in addition to implementation of preventive measures comprising source reduction, insecticidal spray and personal protective measures on a war footing.…”

Section: Introductionmentioning

confidence: 99%

Fatal dengue encephalitis in a recruit: lessons learnt

Pardal¹,

Singh²,

Rath³

et al. 2020

Int J Community Med Public Health

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Dengue infections may present within a widely variable spectrum of clinical manifestations. However, neurologic complications in general are rare and unusual. A 19 yrs old healthy male army recruit was brought to a service hospital in South India in a state of unresponsiveness, following 12 km route march. Despite aggressive and prompt management, his condition progressively deteriorated and he finally passed away about 10 hrs after reporting to the hospital. The final cause of death was acute dengue encephalitis with raised intracranial pressure. Epidemio-clinico-pathological correlation in this case led to the conclusion that vigorous exertion with a hyper-metabolic state of fever in a setting of encephalitis led to metabolic injury, multi-organ failure, cerebral edema and intracranial hemorrhage. Encephalitis following dengue virus (DENV) infection is a rare phenomenon with the incidence ranging from 0.5% to 6.2%. Neurological features associated with DENV were first reported by Sanguansermsri et al in 1976. The rare neurologic presentations reported with DENV infection are transverse myelitis, acute encephalomyelitis, myositis, and gullain barre syndrome. As encephalitis caused by DENV mimics that caused by other pathogens it should always be kept in mind while managing encephalitis of unknown origin. Medical officers should maintain a high index of suspicion of DENV encephalitis. Training of medical officers; therefore, needs to be undertaken with regular refresher cadres, besides equipping of all peripheral facilities with rapid diagnostic kits for dengue. The same will ensure prompt detection of cases and timely referral to higher medical centres in chain. The instant case reflects an important, potentially fatal, complication of dengue. Pathophysiology of DENV encephalitis needs to be elucidated on priority through research involving all stakeholders.

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Current Neurological Observations and Complications of Dengue Virus Infection

Solbrig

Perng

2015

Curr Neurol Neurosci Rep

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Dengue, a mosquito-borne flavivirus and fastest growing tropical disease in the world, has experienced an explosion of neurologic case reports and series in recent years. Now dengue is a frequent or leading cause of encephalitis in some endemic regions, is estimated to infect one in six tourists returning from the tropics, and has been proven to have local transmission within the continental USA. High documentation of neurologic disease in recent years reflects increases in overall cases, enhanced clinical awareness and advances in diagnostics. Neurological aspects of dengue virus, along with epidemiology, treatment, and vaccine progress, are presented.

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Dengue encephalopathy – still an enigma?

Cited by 5 publications

References 5 publications

Japanese Encephalitis Virus Exploits Dopamine D2 Receptor-phospholipase C to Target Dopaminergic Human Neuronal Cells

Japanese Encephalitis Virus Exploits Dopamine D2 Receptor-phospholipase C to Target Dopaminergic Human Neuronal Cells

Fatal dengue encephalitis in a recruit: lessons learnt

Current Neurological Observations and Complications of Dengue Virus Infection

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