BackgroundEpidemics of the dengue virus can trigger widespread morbidity and mortality along with no specific treatment. Examining the spatial autocorrelation and variability of dengue prevalence throughout Bangladesh's 64 districts was the focus of this study.MethodsThe spatial autocorrelation is evaluated with the help of Moran and Geary . Local Moran was used to detect hotspots and cold spots, whereas local Getis Ord G was used to identify only spatial hotspots. The spatial heterogeneity has been detected using various conventional and spatial models, including the Poisson‐Gamma model, the Poisson‐Lognormal Model, the Conditional Autoregressive (CAR) model, the Convolution model, and the BYM2 model, respectively. These models are implemented using Gibbs sampling and other Bayesian hierarchical approaches to analyze the posterior distribution effectively, enabling inference within a Bayesian context.ResultsThe study's findings show that Moran and Geary analysis provides a substantial clustering pattern of positive spatial autocorrelation of dengue fever (DF) rates between surrounding districts at a 90% confidence interval. The Local Indicators of Spatial Autocorrelation cluster mapped spatial clusters and outliers based on prevalence rates, while the local Getis‐Ord G displayed a thorough breakdown of high or low rates, omitting outliers. Although Chattogram had the most dengue cases (15,752), Khulna district had a higher prevalence rate (133.636) than Chattogram (104.796). The BYM2 model, determined to be well‐fitted based on the lowest Deviance Information Criterion value (527.340), explains a significant association between spatial heterogeneity and prevalence rates.ConclusionThis research pinpoints the district with the highest prevalence rate for dengue and the neighboring districts that also have high risk, allowing government agencies and communities to take the necessary precautions to mollify the risk effect of DF.