Dengue hemorrhagic fever: Comparison of patients with primary and secondary infections

Khurram, Muhammad; Qayyum, Wajeeha; Hassan, Syed Jawad ul; Mumtaz, Shumaila; Bushra, Hamama Tul; Umar, Muhammad

doi:10.1016/j.jiph.2014.05.005

Cited by 33 publications

(34 citation statements)

References 15 publications

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“…13,14 Present study also reports high frequency (79%) of secondary dengue cases. Although secondary dengue infection shown to be associated with more severe illness i.e DHF / DSS most probably due to antibody dependent enhancement, primary dengue infection has also been reported to be associated with DHF.…”

Section: Resultssupporting

confidence: 66%

“…Dengue NS1 antigen and Dengue specific IgA antibody based assays have been shown to be useful during early febrile days. [5][6][7][8][9][10][11][12][13][14][15][16][17] ELISA and ICT based NS1 assay have been used as a diagnostic tool during febrile phase till defervescence (1 -9 days of fever onset) however, due to presence of virus -IgG immunocomplexs this assay has shown to be less sensitive in secondary infection as compared to primary infections 18,19 and may give false negative results in dengue endemic and hyperendemic areas. Studies comparing sensitives and specificities of IgA and NS1 reported dengue IgA to be more sensitive during early febrile phase of both primary and secondary dengue infection.…”

Section: -416mentioning

confidence: 99%

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Dengue Rapid Diagnostic Tests; Evaluation of Utility in a Tertiary Care Hospital

Kidwai

Ara

Ghaznawi

et al. 2017

TPMJ

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ABSTRACT… Objectives:To determine the point of care role of dengue IgA and Dengue IgM / IgG rapid diagnostic tests (RDTs) in a tertiary care setting in terms of day of onset of illness at presentation and frequency of positive RDTs in dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Study Design: Cross-sectional study. Setting: Abbasi Shaheed Hospital, Karachi. Period: August-2014 to January-2016. Method: Patients aged 13years and above with acute febrile illness, fulfilling the WHO case definition criteria of probable DF and DHF were included. Two immunochromatograpic (ICT) based RDTs, Assure dengue IgA and Panbio Dengue Duo Cassette (IgM / IgG) were used. Dengue IgA was employed in all patients from day 2 of illness whereas IgM / IgG was employed after day 4 of onset of fever. Result: Among 174 probable cases, 108 (62%) presented between 2 -5 days of onset of fever, among whom 87 (80.5%) were found to be dengue IgA positive. Sixty-nine (39.65%) patients had DHF, among whom 97.1% were seropositive for IgA. Of 118 patients presented after 4 days of onset of illness, 59.3% were positive by IgM / IgG rapid assay. Conclusion: Considering the higher frequency of secondary dengue and DHF in dengue endemic-hyperendemic regions, IgA based ICT might be a helpful diagnostic assay for early diagnosis of dengue infection.

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Section: Resultssupporting

confidence: 66%

Section: -416mentioning

confidence: 99%

Dengue Rapid Diagnostic Tests; Evaluation of Utility in a Tertiary Care Hospital

Kidwai

Ara

Ghaznawi

et al. 2017

TPMJ

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“…Exposure to one DENV serotype confers long-lived immunity against a homotypic secondary infection. However, secondary infection with a heterologous serotype of DENV is the major risk factor to induce severe DENV disease [9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

Pérez-Guzmán

Pantoja

Serrano-Collazo

et al. 2019

Preprint

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34The role of Zika virus (ZIKV) immunity on subsequent dengue virus (DENV) infections is 35 relevant to anticipate the dynamics of forthcoming DENV epidemics in areas with previous ZIKV 36 exposure. We study the effect of ZIKV infection with various strains on subsequent DENV 37 immune response after 10 and 2 months of ZIKV infection in rhesus macaques. Our results 38show that a subsequent DENV infection in animals with early-and middle-convalescent periods 39 to ZIKV do not promote an increase in DENV viremia nor pro-inflammatory status. Previous 40 ZIKV exposure increases the magnitude of the antibody and T cell responses against DENV, 41 and different time intervals between infections alter the magnitude and durability of such 42 responses-more after longer ZIKV pre-exposure. Collectively, we find no evidence of a 43 detrimental effect of ZIKV immunity in a subsequent DENV infection. This supports the 44 implementation of ZIKV vaccines that could also boost immunity against future DENV 45 epidemics. 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61Zika virus (ZIKV) is a re-emerging mosquito-borne Flavivirus that has captivated the 62 attention of the scientific community by its explosive spread in The Americas 1 , and severe 63 neurological sequelae following infection 2-4 . ZIKV established itself in tropical and sub-tropical 64 regions that are endemic to other closely-related flaviviruses such as dengue virus (DENV). 65Both viruses belong to the Flaviviridae family and are transmitted by Aedes spp. mosquitoes. 66DENV is a global public health threat, having two-thirds of world's population at risk of infection, 67 causing ~390 million infections annually 5,6 . DENV exists as four genetically similar but 68 antigenically different serotypes (DENV1-4) 7 . Exposure to one DENV serotype confers long-69 lived immunity against a homotypic secondary infection. However, secondary infection with a 70 heterologous serotype of DENV is the major risk factor to induce severe DENV disease [8][9][10] . 71Due to the antigenic similarities between DENV and ZIKV, concerns have been raised 72 regarding the impact of DENV-ZIKV cross-reactive immunity on the development of severe 73 clinical manifestations 11,12 . It has been demonstrated that DENV-immune sera from humans can 74 enhance ZIKV infection in vitro 13,14 , and in vivo in immune-deficient mouse models 15 . However, 75 recent results from our group and others have shown that previous flavivirus exposure-76including DENV-may have no detrimental impact on ZIKV infection in vivo in non-human 77 primates (NHP) 16,17 and humans 18 . Moreover, these studies and others suggest that previous 78 DENV immunity may play a protective role during ZIKV infection involving humoral and cellular 79 responses 19-23 . On the other hand, little is known about the opposite scenario, the role of a 80 previous ZIKV exposure on subsequent DENV infection, which is relevant to anticipate the 81 dynamics of forthcoming DENV epidemics. 82The recent ZIKV epidemic in the Americas resulted in t...

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“…Secondary infection with different serotype may elicit antibody-dependent enhancement (ADE) response, which facilitates infection of Fc-receptor-bearing cells with DENV and amplified production of cytokines (78). These responses were reported to be linked to severe symptom and increased mortality (910). DHF or DSS have been not reported yet in Korea.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Characteristics and Risk Factors of Dengue Infection in Korean Travelers

Bae

Kim

et al. 2016

J Korean Med Sci

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Dengue viral infection has rapidly spread around the world in recent decades. In Korea, autochthonous cases of dengue fever have not been confirmed yet. However, imported dengue cases have been increased since 2001. The risk of developing severe dengue in Korean has been increased by the accumulation of past-infected persons with residual antibodies to dengue virus and the remarkable growth of traveling to endemic countries in Southeast Asia. Notably, most of imported dengue cases were identified from July to December, suggesting that traveling during rainy season of Southeast Asia is considered a risk factor for dengue infection. Analyzing national surveillance data from 2011 to 2015, males aged 20–29 years are considered as the highest risk group. But considering the age and gender distribution of travelers, age groups 10–49 except 20–29 years old males have similar risks for infection. To minimize a risk of dengue fever and severe dengue, travelers should consider regional and seasonal dengue situation. It is recommended to prevent from mosquito bites or to abstain from repetitive visit to endemic countries. In addition, more active surveillance system and monitoring the prevalence asymptomatic infection and virus serotypes are required to prevent severe dengue and indigenous dengue outbreak.

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Dengue hemorrhagic fever: Comparison of patients with primary and secondary infections

Abstract: Primary dengue infection is frequently associated with DHF. Patients with DHF caused by secondary dengue infection have lower at admission platelet counts and higher ALT value.

Cited by 33 publications

References 15 publications

Dengue Rapid Diagnostic Tests; Evaluation of Utility in a Tertiary Care Hospital

Dengue Rapid Diagnostic Tests; Evaluation of Utility in a Tertiary Care Hospital

Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

Epidemiological Characteristics and Risk Factors of Dengue Infection in Korean Travelers

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