Dengue Infections in Colombia: Epidemiological Trends of a Hyperendemic Country

Gutiérrez-Barbosa, Hernando; Medina‐Moreno, Sandra; Zapata, Juan Carlos; Chua, Joel V

doi:10.3390/tropicalmed5040156

Cited by 55 publications

(69 citation statements)

References 28 publications

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“…Despite the severity, there was no fatal case, and all of them, but one, recovered without sequelae. 8.4 (6.0-7.2) [5] Neutrophils (%) 56 (41-71) [8] 45.6 (31-60) [6] 42.5 [6] 36.6 (28-43) [6] 38.6 (35-51) [6] 32.6 (18.2-43.4) [6] 35.8 (32-37) [5] Lymphocytes (%) 33.9 (19.6-46.8) [8] 47.1 (33-62) [6] 48.9 (87.9-60.3) [6] 52.1 (43-69) [6] 51.8 (36-57) [6] 53.2 (37-67) [6] 40.3 (31-56) [5] Platelets (x1000 cell/μL) 184.8 (109-230) [7] 251.8 (130-372) [7] 266.8 (180-380) [6] 199.1(105-207) [6] 169.2 (88-211) [5] 99.2 (80-88) [5] 271.4 (85-457) [ Case Reports in Medicine e hematimetric analysis indicated anemia and low hematocrit in all patients (median 33.5%, IQR 31.8-34.6%) since the child normal value is 36-42%. A mild leukocytosis was observed at day one and a decrease until day four when leukopenia was evident.…”

Section: Cases Presentationmentioning

confidence: 99%

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A Case Series of Severe Dengue with Neurological Presentation in Children from a Colombian Hyperendemic Area

Castellanos

Esteban

Panqueba-Salgado

et al. 2021

Case Reports in Medicine

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Dengue transmission is sustained in Colombia with increasing prevalence mainly in children. This work aimed to describe a case series of children diagnosed with dengue presenting neurological disease in Huila Province of Colombia. Eleven pediatric febrile patients confirmed for dengue disease and presenting neurological signs were studied in the University Hospital of Neiva, Huila Province. Clinical and laboratory findings, CSF cytochemical analysis, neurology images, and serology and molecular studies were performed. Viral RNA was detected in all patients’ sera by RT-PCR. Nine out of 11 were primary infections. Tonic-clonic seizures (73%), consciousness alterations (27%), irritability (27%), and ataxia (18%) were the most frequent neurological signs. None of the patients had plasma leakage, hypovolemic shock, or liver disease, confirming the encephalitis diagnosis. Diagnostic images did not show abnormal findings, but neither bacterial nor fungal infections were detected in CSF analysis. All patients survived without sequelae except for one patient that presented ataxia for months. In conclusion, we described a group of children with neurological signs during severe dengue disease as the main finding, indicating the importance to including dengue as a differential diagnosis in neurological patients from endemic areas.

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Section: Cases Presentationmentioning

confidence: 99%

“…The largest dengue occurred in Latin America was reported in 2019 with more than three million cases [ 6 ] reaching an incidence rate of 80 cases per 100,000 inhabitants.…”

Section: Introductionmentioning

confidence: 99%

A Case Series of Severe Dengue with Neurological Presentation in Children from a Colombian Hyperendemic Area

Castellanos

Esteban

Panqueba-Salgado

et al. 2021

Case Reports in Medicine

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“…albopictus are continuing public health concerns [ 18 , 19 ]. For example, more than 23 million Colombians—nearly half the country’s population—live in areas considered at risk for dengue infection [ 19 ], and dengue epidemics occur every 3–4 years [ 19 – 21 ]. In Medellín, Colombia’s second largest city, Ae.…”

Section: Introductionmentioning

confidence: 99%

Spatial and temporal population dynamics of male and female Aedes albopictus at a local scale in Medellín, Colombia

et al. 2021

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Background Diseases transmitted by invasive Aedes aegypti and Aedes albopictus mosquitoes are public health issues in the tropics and subtropics. Understanding the ecology of mosquito vectors is essential for the development of effective disease mitigation programs and will allow for accurate predictions of vector occurrence and abundance. Studies that examine mosquito population dynamics are typically focused on female presence or total adult captures without discriminating the temporal and spatial distribution of both sexes. Methods We collected immature and adult mosquitoes bimonthly for 2 years (2018–2019) in the Medellín Botanical Garden. Collection sites differed in proximity to buildings and nearby vegetation, and were classified by their overhead vegetation cover. We used linear mixed models (LMMs) and Spatial Analysis by Distance Indices (SADIE) to assess the spatial distribution of Ae. aegypti and Ae. albopictus. Using our Ae. albopictus captures exclusively, we assessed (1) the spatial and temporal distribution of males and females using SADIE and a generalized linear mixed model (GLMM), (2) the relationship between climatic variables/vegetation coverage and adult captures using GLMMs and LMMs, and (3) the correlation of male and female size in relation to climatic variables and vegetation coverage using LMMs. Results Spatial analysis showed that Ae. aegypti and Ae. albopictus were distributed at different locations within the surveilled area. However, Ae. albopictus was the predominant species in the park during the study period. Adult Ae. albopictus captures were positively correlated with precipitation and relative humidity, and inversely correlated with temperature and wind speed. Moreover, we observed a spatial misalignment of Ae. albopictus males and females—the majority of males were located in the high vegetation coverage sites, while females were more evenly distributed. We observed significant associations of the size of our adult Ae. albopictus captures with precipitation, temperature, and wind speed for both sexes and found that overhead vegetation cover influenced male size, but observed no effect on female size. Conclusions Our work elucidates the differential dynamics of Ae. albopictus males and females, which is pivotal to develop accurate surveillance and the successful establishment of vector control programs based on the disruption of insect reproduction. Graphic Abstract

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“…albopictus are continuing public health concerns [15,16]. For example, more than 23 million Colombians-nearly half the country's population-live in areas considered at risk for dengue infection [16], and dengue epidemics occur every 3-4 years [16][17][18]. In Medellín, Colombia's second largest city, Ae.…”

Section: Introductionmentioning

confidence: 99%

Spatial-Temporal Population Dynamics of Male and Female Aedes Albopictus at a Local Scale in Medellín, Colombia

Camargo

Alfonso-Parra

Díaz

et al. 2021

Preprint

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Background: Diseases transmitted by invasive Aedes aegypti and Aedes albopictus mosquitoes are major public health issues in the tropics and subtropics. Understanding the ecology of mosquito vectors is essential for the development of effective disease mitigation programs and will allow for accurate predictions of vector occurrence and abundance. Studies that examine mosquito population dynamics are typically focused on female presence or total adult captures without discriminating the temporal and spatial distribution of both sexes. Methods: We collected immature and adult mosquitoes twice monthly during a two-year period (2018 – 2019) in the Medellín Botanical Garden (Medellín, Colombia) and assessed: 1) the relationship between climatic variables/vegetation coverage and adult captures, 2) the temporal and spatial distribution of Ae. aegypti and Ae. albopictus during the study period, 3) the temporal and spatial distribution of Ae. albopictus males and females, and 4) the correlation of male and female size in relation to climatic variables and vegetation coverage. Results: We show that Ae. albopictus was the predominant species in the park during the study period. Adult captures were positively correlated with precipitation and relative humidity, and inversely correlated with temperature and wind speed. Spatial analysis showed that Ae. aegypti and Ae. albopictus were distributed at different locations within the surveilled area. Moreover, we observed a spatial misalignment of Ae. albopictus males and females—the majority of males were located in the high vegetation coverage sites and the females in the medium vegetation coverage sites. Conclusions: Our work elucidates the differential dynamics of Ae. albopictus males and females, which is pivotal to develop accurate surveillance and the successful establishment of vector control programs based on the disruption of insect reproduction.

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Dengue Infections in Colombia: Epidemiological Trends of a Hyperendemic Country

Cited by 55 publications

References 28 publications

A Case Series of Severe Dengue with Neurological Presentation in Children from a Colombian Hyperendemic Area

A Case Series of Severe Dengue with Neurological Presentation in Children from a Colombian Hyperendemic Area

Spatial and temporal population dynamics of male and female Aedes albopictus at a local scale in Medellín, Colombia

Spatial-Temporal Population Dynamics of Male and Female Aedes Albopictus at a Local Scale in Medellín, Colombia

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