Dengue Outbreak in Peshawar: Clinical Features and Laboratory Markers of Dengue Virus Infection

Haroon, Muhammad; Jan, Hasnain; Faisal, Shah; Ali, Nasir; Kamran, Muhammad; Ullah, Farhan

doi:10.1016/j.jiph.2018.10.138

Cited by 24 publications

(21 citation statements)

References 21 publications

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“…In 2013, another huge outbreak of infection from KP province was reported with an estimated number of cases of 8546, including 33 deaths in the Swat district according to the WHO report. The prevalent serotypes were serotypes 1, 2, and 3 29‐32 …”

Section: Discussionmentioning

confidence: 99%

Prevalence of dengue virus serotypes in the 2017 outbreak in Peshawar, KP, Pakistan

Khan

Danish

Khan³

et al. 2020

Clinical Laboratory Analysis

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Background Dengue is a viral disease, transmitted by infected Aedes aegypti and Aedes albopictus female mosquitoes. Worldwide, 96 million infections were estimated in 2010. The dengue virus comprises four distinct serotypes (DENV‐1, DENV‐2, DENV‐3, and DENV‐4) which belong to the genus Flavivirus. Determining the serotypes during dengue outbreaks is crucial for its effective management in terms of diagnostics improvement and polyvalent vaccine development. The aim of the present study is to determine the prevalence rate of dengue virus serotypes in the samples collected from patients during the 2017 outbreak in Khyber Pakhtunkhwa, Pakistan. Methods A total of 800 ELISA‐positive samples were collected, of which 513 (290 males, 223 females) samples were confirmed positive by PCR. Results Out of 513, 25 were found serotype 1 (5%), 196 were serotype 2 (38%), 192 were serotype 3 (37%), 56 were serotype 4 (11%), and 44 (8%) were found to have mix serotypes. Conclusion We can conclude that serotypes 2 and 3 of dengue virus were the predominated serotypes of dengue virus in the 2017 outbreak in Peshawar, capital city of Khyber Pakhtunkhwa, Pakistan.

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Section: Discussionmentioning

confidence: 99%

Prevalence of dengue virus serotypes in the 2017 outbreak in Peshawar, KP, Pakistan

Khan

Danish

Khan³

et al. 2020

Clinical Laboratory Analysis

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“…But the serosurveys was also launched in 1960-1980 in different provinces of Pakistan during these surveys test conducted were positive for the neutralizing and Heamaggultination antibodies (Paul et al, 1998). Frist case of dengue infection was reported in 1982 from Punjab, Pakistan (Haroon et al, 2019). In 1994 the 1 st epidemic of dengue fever was reported in Pakistan (Jahan et al, 2011).…”

Section: Dengue Fevermentioning

confidence: 99%

“…It is an epidemiologically unstable disease (Kularatne et al, 2015;Hsieh et al, 2009). After the malaria, dengue fever is the most lethal disease of mosquitoes transmitted diseases, 1-5% is its mortality rate (Agusto et al, 2018;Haroon et al, 2019). When the infected mosquito bites the human it is transmitted into the body through skin (Wiwanitkit et al, 2010).…”

Section: Dengue Fevermentioning

confidence: 99%

Water Resources Helps i̇n the Expansi̇on of Mosqui̇toes Coloni̇es

Haroona¹,

Yaseen²,

Husnain³

et al. 2020

Big. data. water. resour.

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In Pakistan, water storage bodies are often the most plentiful and active habitats of immature stages of mosquitoes. Mosquitoes are blood feeding type of vectors that bite a particular host and suck blood. As a result, these vectors transmit disease causing agents to the host system. The most common mosquitoes borne viral diseases in Pakistan are Chicken gunya, Dengue fever, west nile and Zika fever. These diseases are common in low and poor living standard areas. Death rate increases due to more attack of these fatal diseases. Mosquitoes breeding sites are water bodies, discarded tyres, water tanks, bottles, cups and ant traps. Various environmental agents i.e. temperature fluctuations and water resources, now increase the rate of mosquitos in most areas of Pakistan. There is a lack of basic medical education and knowledge about its pervention techniques in mosquito affected areas in Pakistan. The purpose of this review is to highlight the current status of emerging mosquito borne viral diseases in Pakistan, i.e. Chicken gunya, Dengue fever, est nile and Zika fever. There is more need of prevention strategies and understanding about factors involved in spreading of mosquito borne diseases.

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“…Previously, studies reported the dengue epidemic in Peshawar [11] and Multan [12] in Pakistan. Earlier, dengue got documented from Sheikhupura's neighbouring city of Lahore [13] but, no report surfaced from Sheikhupura.…”

Section: Introductionmentioning

confidence: 99%

The emergence of Dengue Fever in Sheikhupura, Pakistan: its seroprevalence and risk factors assessment during 2014-2017

Mukhtar

Mukhtar²,

Iqbal

et al. 2021

J Infect Dev Ctries

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Introduction: District Sheikhupura encountered its first dengue outbreak in 2014 but lacked serological evidence and reports of risk factors associated with it. To assess this, a hospital-based study was conducted from January 2014 to December 2017. Methodology: Blood from 333 participants was collected, the serum obtained was tested for IgG and IgM antibodies against DENV using a commercially available ELISA kit. Results: The results showed that out of all (n= 333) samples tested, 120 were turned up positive for DENV, making an overall prevalence of 36%. Of the 120 confirmed cases, 55% (n = 66) were recorded in 2014, 10% (n = 12) in 2015, 27.5% (n = 33) in 2016, and 7.5% (n = 9) in 2017. It was found that 68.3% (n = 82) were male and 31.7% (n = 38) were female, with 61% (n = 74) patients aged between 11-30 years. The highest prevalence of infection, 94.2% (n = 113), was noted after the rainy season. During the study, the highest number of cases appeared in Ferozewala Tehsil. The factors age, gender, and season were found statistically significant with the prevalence of infection (p < 0.05). Conclusions: The study is the first report on the detection of dengue in the Sheikhupura district. The survey anticipated its geographical expansion, determined associated risk factors, and suggests active disease surveillance in the area.

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Dengue Outbreak in Peshawar: Clinical Features and Laboratory Markers of Dengue Virus Infection

Cited by 24 publications

References 21 publications

Prevalence of dengue virus serotypes in the 2017 outbreak in Peshawar, KP, Pakistan

Prevalence of dengue virus serotypes in the 2017 outbreak in Peshawar, KP, Pakistan

Water Resources Helps i̇n the Expansi̇on of Mosqui̇toes Coloni̇es

The emergence of Dengue Fever in Sheikhupura, Pakistan: its seroprevalence and risk factors assessment during 2014-2017

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