Dengue RNA detection and seroprevalence in blood donors during an outbreak in the São Paulo State, Brazil, 2016

Slavov, Svetoslav Nanev; Santos, Elaine Vieira; Hespanhol, Marta Regina; Rodrigues, Evandra Strazza; Haddad, Rodrigo; Ubiali, Eugênia Maria Amorim; Covas, Dimas Tadeu; Kashima, Simone

doi:10.1002/jmv.26619

Cited by 6 publications

(4 citation statements)

References 28 publications

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“…In regions with widespread outbreaks of the dengue virus, the probability of receiving blood from asymptomatic donors is high and is easily missed by symptombased exclusion criteria [16]. The high number of asymptomatic blood donors is the principal cause of the rising incidence of reported TT-DENV cases in dengueendemic regions [17][18][19][20]. Asymptomatic individuals have a higher viral load on their peripheral blood circulation, but they do not exhibit signs and symptoms associated with dengue fever.…”

Section: Current Evidence Of Transfusion-transmitted Denguementioning

confidence: 99%

“…Figure 1 illustrates the global region with documented cases of dengue viral markers detected in healthy blood donors. The highest burden of dengue among eligible blood donors is seen in Brazil and India [17,20,[27][28][29][30][31][32][33][34][35]. The burden from other regions is lower, probably masked by a lack of testing and surveillance initiatives.…”

Section: Current Evidence Of Transfusion-transmitted Denguementioning

confidence: 99%

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Dengue Virus Surveillance and Blood Safety: A One Health Perspective

Mulakoli¹,

Gachara²,

Ndombi³

et al. 2023

Infectious Diseases

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The provision of blood products to save a life is a noble undertaking for any organization tasked with the duty. In addition to saving millions of lives, blood products pose health risks associated with adverse events. Much has been done to mitigate these challenges, but emerging new infectious diseases pose a public health challenge to both the safety of blood and its availability. The dengue virus an arbovirus is one such virus that is endemic in tropical and subtropical countries. The data emerging from the published papers show that dengue could be a major threat to blood safety and availability in the future. To address these threats, a collaborative approach through one health system is the only avenue to provide a last solution. One health has been implemented as a strategy to mitigate zoonotic diseases and its results are very impressive. This piece of work is a fraction of our larger project that aims to address threats to the dengue virus and blood safety in Kenya and the rest of Africa. In conclusion, adopting one health in the fight against the dengue virus in blood safety will be the best approach to ensure a safer supply of blood products.

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Section: Current Evidence Of Transfusion-transmitted Denguementioning

confidence: 99%

Section: Current Evidence Of Transfusion-transmitted Denguementioning

confidence: 99%

Dengue Virus Surveillance and Blood Safety: A One Health Perspective

Mulakoli¹,

Gachara²,

Ndombi³

et al. 2023

Infectious Diseases

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“…aegypti mosquitoes, there are also reports of vertical transmission and blood transfusion transmission. Studies, especially in endemic areas such as the Amazon region, should be initiated in blood banks to determine the risk of infection for DENV and other flaviviruses for blood product recipients, especially in epidemic periods [61,62].…”

Section: Dengue Virus (Denv)mentioning

confidence: 99%

Isolation of Flaviviruses and Alphaviruses with Encephalitogenic Potential Diagnosed by Evandro Chagas Institute in the Period of 1954–2022: Six Decades of Discoveries

Wanzeller¹,

Barros²,

Freitas³

et al. 2023

Preprint

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Viruses with encephalitogenic potential can cause neurological conditions of clinical and epidemiological importance, such as Saint Louis encephalitis virus, Venezuelan equine encephalitis virus, Eastern equine encephalitis virus, Western equine encephalitis virus, dengue virus, Zika virus, Chikungunya virus, Mayaro virus and West Nile virus. The objective of the present study was to determine the number of arboviruses with neuroinvasive potential isolated in Brazil that corresponds to the collection of viral samples belonging to the Section of Arbovirology and Hemorrhagic Fevers (SAARB/IEC) of the Laboratory Network of National Reference for Arbovirus Diagnosis from 1954 to 2022. A total of 1,090 arbovirus samples with encephalitogenic potential were isolated from mice. From a total of 7,054 samples intended for cell culture. The isolates from mosquitoes totaled 659 viruses. The emergence of new arboviruses may be responsible for diseases still unknown to humans, making the Amazon region a hotspot for infectious diseases due to its fauna and flora species characteristics. The detection of circulating arboviruses with the potential to cause neuroinvasive diseases is constant, which justifies the continuation of active epidemiological surveillance work that offers adequate support to the public health system regarding the virological diagnosis of circulating arboviruses in Brazil.

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“…The most notorious example includes Dengue viruses 1-4 (DENV 1-4), causing Dengue fever, which is the most important arbovirus disease in the tropics. During large outbreaks, asymptomatically DENV-infected blood donors might be a cause for contamination of donated blood products [12,13]. Clinical complications due to transfusion-transmitted DENV, especially in patients with underlying diseases have also been reported [14][15][16].…”

Section: Viral Metagenomics and Blood Transfusionmentioning

confidence: 99%

Viral Metagenomics for Identification of Emerging Viruses in Transfusion Medicine

Slavov

2022

Viruses

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Viral metagenomics has revolutionized our understanding for identification of unknown or poorly characterized viruses. For that reason, metagenomic studies gave been largely applied for virus discovery in a wide variety of clinical samples, including blood specimens. The emerging blood-transmitted virus infections represent important problem for public health, and the emergence of HIV in the 1980s is an example for the vulnerability of Blood Donation systems to such infections. When viral metagenomics is applied to blood samples, it can give a complete overview of the viral nucleic acid abundance, also named “blood virome”. Detailed characterization of the blood virome of healthy donors could identify unknown (emerging) viral genomes that might be assumed as hypothetic transfusion threats. However, it is impossible only by application of viral metagenomics to assign that one viral agent could impact blood transfusion. That said, this is a complex issue and will depend on the ability of the infectious agent to cause clinically important infection in blood recipients, the viral stability in blood derivatives and the presence of infectious viruses in blood, making possible its transmission by transfusion. This brief review summarizes information regarding the blood donor virome and some important challenges for use of viral metagenomics in hemotherapy for identification of transfusion-transmitted viruses.

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Dengue RNA detection and seroprevalence in blood donors during an outbreak in the São Paulo State, Brazil, 2016

Cited by 6 publications

References 28 publications

Dengue Virus Surveillance and Blood Safety: A One Health Perspective

Dengue Virus Surveillance and Blood Safety: A One Health Perspective

Isolation of Flaviviruses and Alphaviruses with Encephalitogenic Potential Diagnosed by Evandro Chagas Institute in the Period of 1954–2022: Six Decades of Discoveries

Viral Metagenomics for Identification of Emerging Viruses in Transfusion Medicine

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