Dengue seroprevalence study in Bali

Abstract

Introduction Dengue infection poses significant public health problems in tropical and subtropical regions worldwide. The clinical manifestations of dengue vary from asymptomatic to severe dengue manifestations. This serological survey highlighted the high incidence of asymptomatic cases. This study aimed to determine the prevalence of dengue in healthy and ill adults in Bali. Methods Cross-sectional seroprevalence surveys were performed between July 2020 and June 2021 among healthy and ill adults in Denpasar Bali. Blood samples were collected from 539 randomly selected urban sites in Denpasar. Immunoglobulin G antibodies against the dengue virus were detected in serum using a commercial enzyme-linked immunosorbent assay kit. Results Overall, the dengue seroprevalence rate among the 539 clinically healthy and ill adults was high (85.5%). The median age was 34.1 (18–86.1). Most of the participants in the study were younger than 40 years (61.2%). Men were the dominant sex (54.5%). The study found a significant association between dengue seropositivity among people aged > 40 years and healthy status (p = 0.005; odds ratio [OR] = 0.459 and p < 0.001; OR = 0.336, respectively). The study reported that as many as 60% of the subjects had a history of previously suspected dengue infection. This study reflected the proportion of asymptomatic dengue patients requiring better assessment with a serological test. Conclusion The current study highlighted that real cases of dengue infection may be higher than reported, with a high prevalence of dengue seropositivity and a relatively dominant proportion of asymptomatic cases. The study guides physicians to be aware of every dengue infection in tropical countries and prevent the spread of the disease.

A scoping literature review of global dengue age-stratified seroprevalence data: estimating dengue force of infection in endemic countries

“… 49 2019 A 0.037 (0.021, 0.061) PanBio dengue IgG indirect elisa kit (Abbott) Indonesia Denpasar Bali 0–40+ 2 539 indirect IgG ELISA Masyeni et al. 43 Jul 2020–Jun 2021 A 0.036 (0.011, 0.081) Panbio, Lubecl, Germany Indonesia Simpang Kiri (in Subulussalam, Nanggroe Aceh Darussalam) 0–18 18 106 indirect IgG ELISA Tam et al. 50 Oct–Nov 2014 A 0.126 (0.096, 0.162) Panbio dengue IgG ELISA Indonesia Medan Denai (in Medan, Sumatera Utara) 0–18 18 107 indirect IgG ELISA Tam et al.…”

Seropositivity to Dengue virus (DENV) in three neighborhoods in the periphery of a city with a recent history of outbreaks in Argentina: what can we learn from unreported cases?

“…In our study, which included individuals over 18 years of age, we did not find any significant difference in seropositivity by age group. However, studies conducted in hyperendemic areas have found an association with age and attribute it to the fact that the longer people reside in a dengue-endemic region, the greater their risk of exposure, coupled with the lifelong persistence of anti-DENV antibodies [28,29]. In the city of Santa Fe, where the first severe dengue outbreak occurred in 2016 [5], all age groups studied have been exposed to the outbreaks that have occurred since then.…”