Dengue virus infection changes Aedes aegypti oviposition olfactory preferences

Gaburro, Julie; Paradkar, Prasad N.; Klein, Melissa J.; Bhatti, Asim; Nahavandi, Saeid; Duchemin, Jean‐Bernard

doi:10.1038/s41598-018-31608-x

Cited by 27 publications

(26 citation statements)

References 57 publications

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“…Contrary to what has been described previously [33,78], only three members of the chemosensory gene families were differentially regulated in response to a change in infection status. While previous studies have demonstrated a connection between behavioral sensitivity and an increased transcript abundance of select ORs and OBPs [33,34], this study identified IR75k.1 as the only chemosensory gene to change (decrease) in response to DENV-1 infection. The orthologue, AgamIR75k, in Anopheles gambiae has been shown to respond to short chain carboxylic acids [79,80], which regulate host seeking in mosquitoes [81,82].…”

Section: Discussioncontrasting

confidence: 67%

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Dengue infection modulates locomotion and host seeking in Aedes aegypti

Tallon

Lorenzo

Moreira³

et al. 2020

PLoS Negl Trop Dis

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Pathogens may manipulate their human and mosquito hosts to enhance disease transmission. Dengue, caused by four viral serotypes, is the fastest-growing transmissible disease globally resulting in 50-100 million infections annually. Transmission of the disease relies on the interaction between humans and the vector Aedes aegypti and is largely dependent on the odor-mediated host seeking of female mosquitoes. In this study, we use activity monitors to demonstrate that dengue virus-1 affects the locomotion and odor-mediated behavior of Ae. aegypti, reflecting the progression of infection within the mosquito. Mosquitoes 4-6 days post-infection increase locomotion, but do not alter their odor-driven host-seeking response. In contrast, females 14-16 days post-infection are less active, yet more sensitive to human odors as assessed by behavioral and electrophysiological assays. Such an increase in physiological and behavioral sensitivity is reflected by the antennal-specific increase in abundance of neural signaling transcripts in 14 days post-infection females, as determined by transcriptome analysis. This suggests that the sensitivity of the mosquito peripheral olfactory system is altered by the dengue virus by enhancing the overall neural responsiveness of the antenna, rather than the selective regulation of chemosensoryrelated genes. Our study reveals that dengue virus-1 enhances vector-related behaviors in the early stages post-infection that aid in avoiding predation and increasing spatial exploration. On the other hand, at the later stages of infection, the virus enhances the host-seeking capacity of the vector, thereby increasing the risk of virus transmission. A potential mechanism is discussed.

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Section: Discussioncontrasting

confidence: 67%

“…While DENV-2 infection has been shown to affect the odor-mediated oviposition behavior of gravid Ae . aegypti [ 34 ], such an effect has not yet been described for the characteristic odor-mediated behavior of host seeking females.…”

Section: Introductionmentioning

confidence: 99%

Dengue infection modulates locomotion and host seeking in Aedes aegypti

Tallon

Lorenzo

Moreira³

et al. 2020

PLoS Negl Trop Dis

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“…Apparently, several chemicals activate this sensillum (Table 2), indicating that they are putative infochemicals mediating oviposition behavior in mosquitoes (Liu et al 2018). Some of these chemicals have already been shown to mediate oviposition behavior in mosquitoes through behavioral assays (Eneh et al 2016b, Gaburro et al 2018. Such compounds are 3-methylindole, 2-ethylphenol, 4-ethylphenol, and 4-methylphenol (Table 3).…”

Section: Mechanisms Of Odor Reception and Signal Transductionmentioning

confidence: 99%

Exploiting the chemical ecology of mosquito oviposition behavior in mosquito surveillance and control: a review

Mwingira

Mboera

Dicke

et al. 2020

Journal of Vector Ecology

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Vector control is an important component of the interventions aimed at mosquito‐borne disease control. Current and future mosquito control strategies are likely to rely largely on the understanding of the behavior of the vector, by exploiting mosquito biology and behavior, while using cost‐effective, carefully timed larvicidal and high‐impact, low‐volume adulticidal applications. Here we review the knowledge on the ecology of mosquito oviposition behavior with emphasis on the potential role of infochemicals in surveillance and control of mosquito‐borne diseases. A search of PubMed, Embase, Web of Science, Global Health Archive, and Google Scholar databases was conducted using the keywords mosquito, infochemical, pheromone, kairomone, allomone, synomone, apneumone, attractant, host‐seeking, and oviposition. Articles in English from 1974 to 2019 were reviewed to gain comprehensive understanding of current knowledge on infochemicals in mosquito resource‐searching behavior. Oviposition of many mosquito species is mediated by infochemicals that comprise pheromones, kairomones, synomones, allomones, and apneumones. The novel putative infochemicals that mediate oviposition in the mosquito subfamilies Anophelinae and Culicinae were identified. The role of infochemicals in surveillance and control of these and other mosquito tribes is discussed with respect to origin of the chemical cues and how these affect gravid mosquitoes. Oviposition attractants and deterrents can potentially be used for manipulation of mosquito behavior by making protected resources unsuitable for mosquitoes (push) while luring them towards attractive sources (pull). In this review, strategies of targeting breeding sites with environmentally friendly larvicides with the aim to develop appropriate trap‐and‐kill techniques are discussed.

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“…Arbovirus infection may also be associated with changes in the expression of other categories of biological processes, such as arbovirus infection changes in Ae. aegypti blood feeding behavior and oviposition olfactory preferences [46,47,48].…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic Analysis of Aedes aegypti Innate Immune System in Response to Ingestion of Chikungunya Virus

Zhao

Alto

Jiang

et al. 2019

IJMS

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Aedes aegypti (L.) is the primary vector of emergent mosquito-borne viruses, including chikungunya, dengue, yellow fever, and Zika viruses. To understand how these viruses interact with their mosquito vectors, an analysis of the innate immune system response was conducted. The innate immune system is a conserved evolutionary defense strategy and is the dominant immune system response found in invertebrates and vertebrates, as well as plants. RNA-sequencing analysis was performed to compare target transcriptomes of two Florida Ae. aegypti strains in response to chikungunya virus infection. We analyzed a strain collected from a field population in Key West, Florida, and a laboratory strain originating from Orlando. A total of 1835 transcripts were significantly expressed at different levels between the two Florida strains of Ae. aegypti. Gene Ontology analysis placed these genes into 12 categories of biological processes, including 856 transcripts (up/down regulated) with more than 1.8-fold (p-adj (p-adjust value) ≤ 0.01). Transcriptomic analysis and q-PCR data indicated that the members of the AaeCECH genes are important for chikungunya infection response in Ae. aegypti. These immune-related enzymes that the chikungunya virus infection induces may inform molecular-based strategies for interruption of arbovirus transmission by mosquitoes.

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Dengue virus infection changes Aedes aegypti oviposition olfactory preferences

Cited by 27 publications

References 57 publications

Dengue infection modulates locomotion and host seeking in Aedes aegypti

Dengue infection modulates locomotion and host seeking in Aedes aegypti

Exploiting the chemical ecology of mosquito oviposition behavior in mosquito surveillance and control: a review

Transcriptomic Analysis of Aedes aegypti Innate Immune System in Response to Ingestion of Chikungunya Virus

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