Dengue Virus Serotype 4 Is Responsible for the Outbreak of Dengue in East Java City of Jember, Indonesia

Aryati, Aryati; Wrahatnala, Billy Jordan; Yohan, Benediktus; Fanny, May; Hakim, Faradila K. N.; Sunari, Eka Putri; Zuroidah, Nelly; Wardhani, Puspa; Santoso, Marsha S.; Husada, Dominicus; Rohman, Ali; Tarmizi, Siti Nadia; Sievers, Justus T. O.; Sasmono, R. Tedjo

doi:10.3390/v12090913

Cited by 19 publications

(20 citation statements)

References 47 publications

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“…Molecular epidemiology has become an indispensable tool in determining routes and sources of infection in human and animal viral infections. Determination and comparison of viral variants, sero- or genotypes, has proven vital, not only in the current coronavirus pandemic but also in allowing us to link the new introduction of serotype 4 to emerging outbreaks of dengue virus in Indonesia, or recognize frozen berries as the source of a multistate outbreak of hepatitis A in Europe [ 28 , 29 , 30 ]. Furthermore, substantial sequence databases have helped tracing chains of (re-)infection of bovine viral diarrhea virus and supported the eradication of this epizootic cattle pathogen in Switzerland and Scotland [ 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic Diversity of Hepatitis E Virus Type 3 in Switzerland—From Stable to Table

Vonlanthen-Specker

Stephan

Sidler

et al. 2021

Animals

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Hepatitis E caused by hepatitis E viruses of the genotype 3 (HEV-3) is a major health concern in industrialized countries and due to its zoonotic character requires a “One Health” approach to unravel routes and sources of transmission. Knowing the viral diversity present in reservoir hosts, i.e., pigs but also wild boars, is an important prerequisite for molecular epidemiology. The aim of this study was to gain primary information on the diversity of HEV-3 subtypes present along the food chain in Switzerland, as well as the diversity within these subtypes. To this end, samples of domestic pigs from slaughterhouses and carcass collection points, as well as from hunted wild boars, were tested for HEV RNA and antibodies. HEV positive meat products were provided by food testing labs. The HEV subtypes were determined using Sanger and next generation sequencing. The genetic analyses confirmed the predominance of a Swiss-specific cluster within subtype HEV-3h in pigs, meat products, and wild boars. This cluster, which may result from local virus evolution due to the isolated Swiss pig industry, supports fast differentiation of domestic and imported infections with HEV.

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Section: Introductionmentioning

confidence: 99%

Genetic Diversity of Hepatitis E Virus Type 3 in Switzerland—From Stable to Table

Vonlanthen-Specker

Stephan

Sidler

et al. 2021

Animals

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“…Although having the lowest prevalence, DENV-4 still has the potential to cause severe dengue manifestation (DHF), as reported in a previous study [17]. The dengue outbreak in Jember manifested as milder (DF) disease, with only 26.7% of patients showing DHF manifestation [13]. Nevertheless, the predominance of DENV-4 during the outbreak raised awareness and scientific questions on whether there are virus factors that contributed to this phenomenon.…”

Section: Introductionmentioning

confidence: 84%

“…Serum samples were collected during a DENV surveillance study in Jember, East Java, from May 2019 to March 2020, which revealed the predominance of DENV-4 [13]. The use of human serum samples in the study was granted ethical approval from the Research Ethics Committee of the Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia (Ethical Approval No.…”

Section: Sample Collection and Preparationmentioning

confidence: 99%

“…The predominance of DENV serotypes is not constant, with documented reports of predominance switch between serotypes and evidence of genotype switching within each serotype [10][11][12]. A recent 2019 dengue outbreak in Jember, a regency in East Java, Indonesia, recorded the predominance of DENV-4, which is rarely seen during dengue outbreaks in Indonesia [13].…”

Section: Introductionmentioning

confidence: 99%

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Genetic characterization of dengue virus 4 complete genomes from East Java, Indonesia

Wardhani

Yohan²,

Tanzilia³

et al. 2022

Virus Genes

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Dengue is an endemic arboviral disease with continuous transmission in Indonesia for more than five decades. A recent outbreak in Jember, East Java province, demonstrated the predominance of DENV-4, a serotype known for its low global spread and limited transmission. While epidemiological factors such as new serotype introduction and lacking herd immunity may explain its predominance, viral factors may also contribute. Using next-generation sequencing, we generated 13 representative complete genomes of DENV-4 responsible for the outbreak. Phylogenetic and evolutionary analyses on complete genomes were performed to understand the spatial and temporal dynamics of the viruses. Further analyses were done to study amino acid variations in DENV genes, as well as the potential events of recombination and selection pressure within the genomes. We revealed the DENV-4 genetic factors that may lead to its predominance in the 2019 Jember dengue outbreak. A combination of selection pressure and mutational genetic changes may contribute to the DENV-4 predominance in East Java, Indonesia. The possible intra-serotype recombination events involving the non-structural protein 5 (NS5) gene were also observed. Altogether, these genetic factors may act as additional factors behind the complex dengue outbreak mechanism.

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“…The DENV-4 was the least-reported serotype in Indonesia during the last five decades. 3 In 2013, the Ministry of Health of Indonesia (MoHI) reported 112,511 cases (dengue Incidence Rate (IR) of 41.25 per 100,000 population) and 871 deaths corresponding to a Case Fatality Rate (CFR) of 0.7%. 4 West Java is home to about 20% of Indonesia's total population, making it one of the most densely populated provinces in the country.…”

Section: Introductionmentioning

confidence: 99%

Spatio-Temporal Analysis of Dengue Cases in Kuningan District Since 2008-2017

Fuadiyah¹,

Ruliansyah²

2022

blb

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Dengue has spread to over 400 of Indonesia’s 497 districts, including West Java Province in which 26 of its districts have been declared as hyper-endemic. A study was conducted to describe the spread of dengue incidences and its cluster during 2008-2017 in Kuningan District. The district is located in an important route, in migration and in the economic field, connecting the northern part of West Java to the southern part. A spatio-temporal analysis based on monthly dengue incidences from the local District Health Office was performed using SaTScan™. This study revealed there were Statistically significant high-risk dengue clusters with various RR in half of the subdistricts in Kuningan in the ten-year periods of 2008-2017 and a retrospective space-time analysis detected 17 significant clusters (P<0.001). Subdistrict Kuningan is detected as a high-risk area every year except for 2008, whereas Jalaksana emerged as a high-risk cluster in six of ten-year periods. We conclude that there was a dynamic spread of dengue cases initiated from the north part of Kuningan District to western areas. This study results do not properly predict RR due to a lack of information on some significant factors, such as vector density and related environmental and socioeconomic parameters. However, this study has provided a perspective on dengue incidence that can be used by local health managers and disease surveillance personnel to monitor prospective outbreaks and make decisions about how to implement an effective response.

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Dengue Virus Serotype 4 Is Responsible for the Outbreak of Dengue in East Java City of Jember, Indonesia

Cited by 19 publications

References 47 publications

Genetic Diversity of Hepatitis E Virus Type 3 in Switzerland—From Stable to Table

Genetic Diversity of Hepatitis E Virus Type 3 in Switzerland—From Stable to Table

Genetic characterization of dengue virus 4 complete genomes from East Java, Indonesia

Spatio-Temporal Analysis of Dengue Cases in Kuningan District Since 2008-2017

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