Landfill leachates from municipal landfills are usually heavily contaminated and thus require treatments before direct discharge into natural waters. Selecting the appropriate technology for leachate treatment is still a major challenge for operations in municipal landfills. Biodegradation is effective for treating young leachates, whereas old leachates require processes such as chemical oxidation, coagulation-flocculation, chemical precipitation, ozonation, activated carbon adsorption, and reverse osmosis. Recently, the combination of biological pretreatments followed by physico-chemical processes has been shown to be very efficient. Here we review the efficiency of biological treatment in combination with reverse osmosis to clean landfill leachates. We studied in particular processes including a membrane bioreactor, activated sludge, a rotating biological contactor, and up-flow anaerobic sludge blanket treatments, followed by reverse osmosis. We found a 99-99.5% removal of the chemical oxygen demand (COD), and a 99-99.8% removal of N-NH 4 + using reverse osmosis and activated sludge. Using reverse osmosis with a rotating biological contactor, we observed 99% removal of COD, biochemical oxygen demand and N-NH 4 + . The combination of reverse osmosis, activated sludge and rotating biological contactor removed 98-99.2% of Cl − and 99-99.7% of Pb. Total suspended solids are best removed, up to 99%, by either a combination of reverse osmosis with membrane bioreactor, or reverse osmosis with activated sludge.