Thanks to the rapid development of CNNs and depth sensors, great progress has been made in 3D hand pose estimation. Nevertheless, it is still far from being solved for its cluttered circumstance and severe self-occlusion of hand. In this paper, we propose a method that takes advantage of human hand morphological topology (HMT) structure to improve the pose estimation performance. The main contributions of our work can be listed as below. Firstly, in order to extract more powerful features, we concatenate original and last layer of initial feature extraction module to preserve hand information better. Next, regression module inspired from hand morphological topology is proposed. In this submodule, we design a tree-like network structure according to hand joints distribution to make use of high order dependency of hand joints. Lastly, we conducted sufficient ablation experiments to verify our proposed method on each dataset. Experimental results on three popular hand pose dataset show superior performance of our method compared with the state-of-the-art methods. On ICVL and NYU dataset, our method outperforms great improvement over 2D state-of-the-art methods. On MSRA dataset, our method achieves comparable accuracy with the state-of-the-art methods. To summarize, our method is the most efficient method which can run at 220.7 fps on a single GPU compared with approximate accurate methods at present. The code will be available at a . a https://github.com/weiguochow/HMTNet INDEX TERMS 3D hand pose estimation, concatenated feature, hand morphological topology, single depth image.