Densification behavior of pure Zn metal parts produced by selective laser melting for manufacturing biodegradable implants

Wen, Peng; Jauer, Lucas; Voshage, Maximilian; Chen, Yanzhe; Poprawe, Reinhart; Schleifenbaum, Johannes Henrich

doi:10.1016/j.jmatprotec.2018.03.007

Cited by 113 publications

(56 citation statements)

References 20 publications

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“…Other notable works on pure Zn include: (i) the fabrication of ultrapure (6 N) Zn minitubes by Liu et al [75]; (ii) the manufacture of a functional Zn (4 N) stent by Hiebl et al [76]; (iii) studies on the feasibility of using additive manufacturing techniques to form Zn by Demir et al [77], Yang et al [78], and Wen et al [79,80]; (iv) a study on the in vitro degradation of Zn (99.9%) in saline solutions, plasma and whole blood by Torne et al [81,82]; (v) studies on the influence of Zn +2 ions on the in vitro viability of human cells by Ma et al [83] and Shearier et al [84]; (vi) a study on the in silico, in vitro and antifungal activity of surface corrosion products formed during the biodegradation of Zn by Alves et al [85]; and (vii) a long-term study on the in vivo degradation of an actual Zn [86]. Furthermore, a lot of work on binary alloys would often characterize pure Zn as this serves as the control in the respective experiments.…”

Section: Pure Znmentioning

confidence: 99%

“…The prospects for the use of AM techniques in fabricating biodegradable Zn [77,79,80,133,134] and Zn alloys (e.g., Zn-Mg) [78] appears promising. Selective laser melting (SLM), which is a type of AM process that produces metal parts by the fusion of powders using high power lasers, has been identified as a viable technique.…”

Section: Advanced Processing Techniquesmentioning

confidence: 99%

“…Demir et al [77] adopted an open-air chamber instead of a closed one and, after optimizing several process conditions, reported on achieving 99% part densities. Likewise, Wen et al [79,80] optimized the SLM processing parameters and created part densities of about 99.9%. They also noted how part porosity resulted from either (i) lack of fusion due to inadequate laser energy or (ii) via gas entrapment caused by excessive metal evaporation.…”

Section: Advanced Processing Techniquesmentioning

confidence: 99%

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The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

2019

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Zinc has been identified as one of the most promising biodegradable metals along with magnesium and iron. Zinc appears to address some of the core engineering problems associated with magnesium and iron when applied to biomedical implant applications; hence the increase in the amount of research investigations on the metal in the last few years. In this review, the current state-of-the-art on biodegradable Zn, including recent developments, current opportunities and future directions of research are discussed. The discussions are presented with a specific focus on reviewing the relationships that exist between mechanical properties, biodegradability, and biocompatibility of zinc with alloying and fabrication techniques. This work hopes to guide future studies on biodegradable Zn that will help in advancing this field of research. Statement of Significance (i) The review offers an up-to-date and comprehensive review of the influence of alloying and fabrication technique on mechanical properties, biodegradability and biocompatibility of Zn; (ii) the work cites the most relevant biodegradable Zn fabrication processes including additive manufacturing techniques; (iii) the review includes a listing of research gap and future research directions for the field of biodegradable Zn.

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Section: Pure Znmentioning

confidence: 99%

Section: Advanced Processing Techniquesmentioning

confidence: 99%

Section: Advanced Processing Techniquesmentioning

confidence: 99%

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The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

2019

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“…Although no human trials have been carried out on Zn or Fe based degradable implants, they remain a valid option for bioabsorbable implants [187]. The ability to process both of these materials has been demonstrated in L-PBF [204], with densities in excess of 99% achievable in Zn [205,206]. Unlike Mg alloys, Fe based alloys often feature excessively slow degradation due to passivation, a problem that has been combated in L-PBF by addition of silver to optimise corrosion properties [207].…”

Section: Bioactive Alloysmentioning

confidence: 99%

Clinical, industrial, and research perspectives on powder bed fusion additively manufactured metal implants

Lowther

Louth

Davey

et al. 2019

Additive Manufacturing

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A B S T R A C TFor over ten years, metallic skeletal endoprostheses have been produced in select cases by additive manufacturing (AM) and increasing awareness is driving demand for wider access to the technology. This review brings together key stakeholder perspectives on the translation of AM research; clinical application, ongoing research in the field of powder bed fusion, and the current regulatory framework. The current clinical use of AM is assessed, both on a mass-manufactured scale and bespoke application for patient specific implants. To illuminate the benefits to clinicians, a case study on the provision of custom cranioplasty is provided based on prosthetist testimony. Current progress in research is discussed, with immediate gains to be made through increased design freedom described at both meso-and macro-scale, as well as long-term goals in alloy development including bioactive materials. In all cases, focus is given to specific clinical challenges such as stress shielding and osseointegration. Outstanding challenges in industrialisation of AM are openly raised, with possible solutions assessed. Finally, overarching context is given with a review of the regulatory framework involved in translating AM implants, with particular emphasis placed on customisation within an orthopaedic remit. A viable future for AM of metal implants is presented, and it is suggested that continuing collaboration between all stakeholders will enable acceleration of the translation process. fection or surgical complications [11][12][13].Currently, the majority of skeletal endoprostheses are produced from titanium (Ti) or cobalt chromium (CoCr) based alloys, which meet the criteria of durability, strength, corrosion resistance and a low immune response [14,15]. These characteristics however come at the cost of the high stiffness of these alloys in comparison to bone. Mismatch between the mechanical properties of bone and orthopaedic materials

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“…In contrast, the processing of zinc by SLM is a challenge because of the low melting point and boiling point, causing the prepared sample is low-density and unstable [32]. By optimizing the powder and processing technology, the quality of the prototype can be effectively improved, thereby realizing the preparation of zinc implants with excellent properties [78]. However, pure zinc is difficult to satisfy the clinical mechanical requirements of bearing bone.…”

Section: (3) Degradable Metalsmentioning

confidence: 99%

Additive Manufacturing of Customized Metallic Orthopedic Implants: Materials, Structures, and Surface Modifications

Bai

Cheng

Chen

et al. 2019

Metals

131

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Metals have been used for orthopedic implants for a long time due to their excellent mechanical properties. With the rapid development of additive manufacturing (AM) technology, studying customized implants with complex microstructures for patients has become a trend of various bone defect repair. A superior customized implant should have good biocompatibility and mechanical properties matching the defect bone. To meet the performance requirements of implants, this paper introduces the biomedical metallic materials currently applied to orthopedic implants from the design to manufacture, elaborates the structure design and surface modification of the orthopedic implant. By selecting the appropriate implant material and processing method, optimizing the implant structure and modifying the surface can ensure the performance requirements of the implant. Finally, this paper discusses the future development trend of the orthopedic implant.

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Densification behavior of pure Zn metal parts produced by selective laser melting for manufacturing biodegradable implants

Cited by 113 publications

References 20 publications

The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

Clinical, industrial, and research perspectives on powder bed fusion additively manufactured metal implants

Additive Manufacturing of Customized Metallic Orthopedic Implants: Materials, Structures, and Surface Modifications

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